differentiation

Misleading evidence, Raman Hyperspectroscopy and FB jail

June 5, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the News
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Yesterday, on the topic of vaccines used to prevent Ebola virus transmission, I wrote: …. There is no such thing as an extinct virus. Their ability to steal energy is biophysically constrained until nutrient stress and/or social stress cause their reactivation. I provided a link to The Darwin Code Today, I read about The misleading evidence that fooled scientists for decades After posting this comment to “The Conversation,” I learned I was blocked from posting anything to Facebook. Have you considered…

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The eternal significance of microRNAs (8)

May 15, 2018
James Kohl
Adaptations, Diseases & Disorders, Ecology, microRNA editing, RNA Directed, RNA interference, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity
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Use of definitions in attempts to explain any aspect of species-specific biophysically constrained cell type differentiation and aging has been replaced by the use of model systems of biological processes.  Biological processes can be compared to so-called “evolutionary processes” to show that only biological processes need to be considered in the context of Darwin’s “conditions of life” or answers to the the question  What is Life? Schrödinger (1944). K. L. Mettinger et al. (eds.), Exosomes, Stem Cells and MicroRNA, Advances…

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Epigenetic facts vs variable recombination theories

November 7, 2017
James Kohl
Adaptations, Alternative Splicings, base editing, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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6/14/13 Nutrient-dependent/pheromone-controlled adaptive evolution: a model ….the model represented here is consistent with what is known about the epigenetic effects of ecologically important nutrients and pheromones on the adaptively evolved behavior of species from microbes to man. Minimally, this model can be compared to any other factual representations of epigenesis and epistasis for determination of the best scientific ‘fit’. 7/25/13 Jay R. Feierman: Variation is not nutrient availability and the something that is doing the selecting is not the individual…

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Pheromones biophysically constrain RNA-mediated biodiversity (1)

November 3, 2017
James Kohl
Adaptations, Alternative Splicings, base editing, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, RNA Directed, RNA editing, Variations
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Elaine Morgan on paradigm shifts. Her view of the pseudoscientific nonsense touted by neo-Darwinian theorists and “Big Bang” cosmologists is humorous and she accurately represents what’s been happening to me and others like me for the past two decades. It’s what we expect. It’s your choice to keep laughing about it. See for comparison: Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest Reported as: Scientists have identified the metabolic pathway associated with heart…

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Theories vs facts about polycombic adaptation

December 6, 2016
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Model Organisms, Nutrigenomics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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See: Demoncrats fight polycombic ecological adaptation Exosomes as miRNA Carriers: Formation–Function–Future Important aspects will be highlighted as a take-home message (THM) at the end of each paragraph. THM: Extracellular vesicles transport miRNA in a paracrine and endocrine manner. Questions regarding the cellular options of producing either microvesicles or exosomes and their difference in miRNA composition and number are still unknown. In my 2014 invited review, the four F’s, Formation–Function–Future and Copulation were included in details about how the nutrient energy-dependent…

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Energy-dependent maternal-to-zygotic transition

November 15, 2016
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Small Non-coding RNAs Associated with Viral Infectious Diseases of Veterinary Importance: Potential Clinical Applications ON 11/14/16 The co-author Mohamed Samir wrote:  Because our article is among the top 25% most viewed and downloaded articles in the third quarter of 2016 in “Frontiers in Veterinary Science”, The editor of the journal has invited me to host and moderate a new research topic in his journal about miRNAs in veterinary filed. Thanks God. The topic is virtually guaranteed to bring out the…

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Life is energy-dependent task management

October 5, 2016
James Kohl
Adaptations, Autophagy, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, Nutrigenomics, RNA Directed, RNA methylation, RNA-directed DNA methylation, Variations
One Comment

See also: Life is energy-dependent task management (2) Press Release: The Nobel Prize in Chemistry 2016  for the design and synthesis of molecular machines Excerpt: They have developed molecules with controllable movements, which can perform a task when energy is added. My comment: When energy is added is the key to understanding healthy longevity in the context of popular information Popular information (link opens pdf) Excerpt: All chemical systems strive for equilibrium – a lower energy state – but this…

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Theorists can’t understand biology

November 19, 2015
James Kohl
Adaptations, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Physics, RNA Directed, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, Variations
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See also: Neuroplasticity Thanks to Teresa Binstock for calling my attention to this:   Thanks to Anna Di Cosmo for calling the attention of others to this: My comment: Attempts to explain the “binding problem” of integration in the context of ecoimmunology and disease ecology compared to emergence and evolution are examples of how much pseudoscientific nonsense has been accepted and touted in the context of the neo-Darwinian “Modern Synthesis.” For comparison, serious scientists have detailed a model of top-down…

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Cell type differentiation: atoms to ecosystems

November 17, 2015
James Kohl
Adaptations, Ecology, Model Organisms, RNA Directed, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, Variations
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Relaxed genetic control of cortical organization in human brains compared with chimpanzees Abstract conclusion: A major result of increased plasticity is that the development of neural circuits that underlie behavior is shaped by the environmental, social, and cultural context more intensively in humans than in other primate species, thus providing an anatomical basis for behavioral and cognitive evolution. Reported as: Nature and nurture: Human brains evolved to be more responsive to environmental influences Excerpt: …the morphology of the human cerebral…

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Conserved molecular mechanisms

November 14, 2015
James Kohl
Adaptations, Ecology, Model Organisms, Neuronal Plasticity, RNA Directed, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, Variations
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Functional Conservation of the Glide/Gcm Regulatory Network Controlling Glia, Hemocyte and Tendon Cell Differentiation in Drosophila Abstract excerpt: High throughput screens allow us to understand how transcription factors trigger developmental processes including cell specification. A major challenge is the identification of their binding sites because feedback loops and homeostatic interactions may mask the direct impact of those factors in transcriptome analyses. My comment: Evolutionary theorists must accept the fact that feedback loops and homeostatic interactions are conserved and stop making…

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