DNA Base Pairs

Polycombic ecological adaptation as a science, not a theory (2)

Evolutionary Constraints in the β-Globin Cluster: The Signature of Purifying Selection at the δ-Globin (HBD) Locus and Its Role in Developmental Gene Regulation Conclusion: … the results here presented indicate that purifying selection is driving not only HBD evolution but also its neighbor pseudogene, HBBP1. In the light of recent advances in the characterization of the β-globin cluster, we propose that the complex patterns of diversity observed in this genomic region arose from distinct functional constraints related with the intricate…

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Hydrogen-atom energy in DNA base pairs

See also: Consciousness is simply food rearranged Role of Double Hydrogen Atom Transfer Reactions in Atmospheric Chemistry Abstract excerpt:  Hydrogen atom transfer (HAT) reactions are ubiquitous and play a crucial role in chemistries occurring in the atmosphere, biology, and industry. My comment: The link from physics to chemistry and the conserved molecular mechanisms of biologically-based RNA-mediated cell type differentiation has been the focus my works for more than 20 years, even before I knew what I would need to explain…

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Energy-dependent RNA-mediated immunity (1)

Regulatory evolution of innate immunity through co-option of endogenous retroviruses Excerpt: The analysis revealed a primate-specific element that orchestrates the transcriptional response to interferons. Selection can therefore act on selfish genetic elements to generate novel gene networks. Reported as: A copy-and-paste gene regulatory network Excerpt: Chuong et al. provide evidence that concerted processes, involving endogenous retroviruses (ERVs), which are remarkably abundant in mammalian genomes, have contributed to the evolution of the regulatory systems that control the mammalian immune system (6).…

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Effects on invertebrate GnRH and affects on primate behavior

Introduction: Energy-dependent changes in hydrogen-atom transfer in DNA base pairs in solution have again been linked to hormone-organized and hormone-activated behaviors by the conserved molecular mechanisms we detailed in the molecular epigenetics section of our 1996 Hormones and Behavior review. The practical application of those details has been reported in the context of this article, published in the New England Journal of Medicine. Effects of Testosterone Treatment in Older Men Daily Diagnosis is emailed each weekday to members of the…

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Bacteria see the light and they adapt

Cyanobacteria use micro-optics to sense light direction Excerpt: From the observed dimensions of the spot of 488 nm light focused by Synechocystis cells (Figure 3c) we can estimate that Synechocystis “vision” has an angular resolution (FWHM) of about 21°, essentially limited by light wavelength and the area of the plasma membrane, which is tiny in comparison to an animal retina. However, this resolution is sufficient to incorporate quite complex spatial information into a 360° image of the cell’s surroundings, and…

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Intelligent RNAs vs evolved genes

Intelligent RNAs in the Brain Excerpt: Alternative RNA splicing and non-coding RNA particles have evolved unusually rapidly. Intelligent RNAs in the brain have fostered rapid human evolution. Tom Robbins Do we have to say “evolved” for everything? The complexity here is intelligent, no matter what you call it, evolved implies with no direction, an mainly by chance, which is an outmoded term for this level of complexity. I get so tired of trying to latch on a dead end theory…

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Hydrogen-Atom Transfer in DNA Base Pairs (3)

Video of our insignificance The video can be compared to what is known to serious scientists about the answer to Schrodinger’s question: What is Life? Excerpt:  But about forty years ago the Dutchman de Vries discovered that in the offspring even of thoroughly pure-bred stocks, a very small number of individuals, say two or three in tens of thousands, turn up with small but ‘jump-like’ changes, the expression ‘jump-like’ not meaning that the change is so very considerable, but that…

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Hydrogen-Atom Transfer in DNA Base Pairs (2)

See also: Hydrogen-Atom Transfer in DNA Base Pairs Ultrafast vibrational dynamics of the DNA backbone at different hydration levels mapped by two-dimensional infrared spectroscopy Conclusions excerpt: …the hydration level is substantially below a bulk water environment existing under physiological conditions. To get insight into this biologically most relevant scenario, future work will address the behavior of longer DNA helices and RNA with sodium counterions, embedded in bulk liquid water. Such work will also help to assess the role of long-range…

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