DNA methylation

Metabolism, fixation, health or neurodegerative disorder

“Shown is the location of the conserved regions encoding for the N-terminal chromo domain and the C-terminal MYST functional domain. An arrow denotes the position site of amino acid substitution E431Q.” Microarray Analysis Uncovers a Role for Tip60 in Nervous System Function and General Metabolism My comment: The article links a nutrient-dependent amino acid substitution via changes in metabolism to cell type differentiation, multicellularity, and brain development in Drosophila. It suggests the substitution is fixed by the model organism’s pheromone-controlled…

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Physics denied; pseudoscientific nonsense accepted

  The events depicted are now portrayed in the context of Genome Dynamics Events, which are biophysically-constrained RNA-mediated events. RNA-mediated events lead to amino acid substitutions that differentiate the cell types of species. For example: “…the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla.” Dobzhansky (1973) See also: God, Darwin and My College Biology Class By DAVID P.…

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Evolving DNA before RNA

A Tiny Emissary From the Ancient Past SEPT. 25, 2014 by Carl Zimmer Excerpt 1) The evolutionary origins of viruses and viroids are totally different…” My comment: How could evolution origins be totally different for anything? Has neo-Darwinian theory changed to allow some organisms to evolve via mutations and some to evolve another way? Excerpt 2) The ancestors of plants gained the ability to capture sunlight by swallowing up photosynthetic microbes. Dr. Flores speculated that these microbes, called cyanobacteria, may…

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Stop evolutionary theorists. Kill cancers

Bacterial ‘communication system’ could be used to stop, kill cancer cells, study finds Excerpt: “During an infection, bacteria release molecules which allow them to ‘talk’ to each other,” said the lead author of the study. “Depending on the type of molecule released, the signal will tell other bacteria to multiply, escape the immune system or even stop spreading.” My comment: Nutrient-dependent cell type proliferation is pheromone-controlled during health and infections — and in other diseases and disorders. The conserved molecular…

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Seemingly futile cycles are not thermodynamically futile

Scientists discover an on/off switch for aging cells The switch controls the growth of telomeres, the timekeepers of cells September 19, 2014 Excerpt: Understanding how this “off” switch can be manipulated–thereby slowing down the telomere shortening process–could lead to treatments for diseases of aging (for example, regenerating vital organs later in life).” My comment: Seemingly futile thermodynamic cycles of protein biosynthesis and  degradation appear to be confusing. I’m somewhat certain that the folks at Salk realize that cycles of biophysically-constrained…

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Pheromone-controlled thermodynamics and cancer

“If you learnt evolutionary biology and genetics a decade or more ago you need to be aware that those debates have moved on very considerably, as has the experimental and field work on which they are based.” — Denis Noble Can thermodynamics help us better understand human cancers? Excerpt: “In a new study, UCLA researchers analyzed the gene-expression profiles of more than 2,000 patients and were able to identify cancer-specific gene signatures for breast, lung, prostate and ovarian cancers. The…

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Evolution: innovations may have non-adaptive origins (sans mutations)

Q & A: Evolution Makes Do By Chris Palmer Evolutionary biologist Andreas Wagner argues that many evolutionary innovations may have non-adaptive origins. Excerpt: “If exaptations are pervasive, then natural selection—which few doubt is critical for the preservation and spreading of traits—may not be that important for the origin of innovations in life’s history.” See also: Rapid detection of positive selection in genes and genomes through variation clusters Excerpt: “They occur in well-defined domains of a protein’s tertiary structure and show…

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