DNA methylation

Sexual communication signals: New Insights!

Nobody wants to belong to the party of losers. One of the best strategies in such a case is evidently an interpretation of the change as a gradual accumulation of knowledge while their work has always been at the cutting edge. — Kalevi Kull New insights in the evolution of sexual communication signals Abstract excerpt: Our research focuses on identifying a) the genes underlying sexual signals and responses in both sexes2-4, and b) ecological factors that may cause divergence in…

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Energy-dependent de novo creation and neurogenesis

See also: Tasting light links energy from creation to adaptation Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning reported as: When neurons are ‘born’ impacts olfactory behavior in mice My summary: The de novo creation of different cell types is placed into the context of their energy-dependent birth and the transgenerational epigenetic inheritance of molecular mechanisms that link virus-driven energy theft to all pathology via olfaction, food odors, and human pheromones. See for comparison: Metabolism and neurogenesis …it…

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Light ‘drives’ adaptation; nothing ‘drives’ evolution (2)

See: Light ‘drives’ adaptation; nothing ‘drives’ evolution See also: Who rules the waves? – Viruses might just be bit players in the drama of the seas. Then again, they could be major actors Excerpt (from 1996):  Most consider viruses to be a legion of cripples, sterilised by ultraviolet radiation and rendered impotent by hosts that are largely immune to their threat. But a few researchers take the opposite view. And if they turn out to be right, viruses could radically…

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Base pairs, olfaction and RNA thermometers

RNA thermometer controls temperature-dependent virulence factor expression in Vibrio cholerae (2014) Excerpt: The stem-loop can be stabilized by strengthening the base pairing between the fourU element and SD sequence through the substitution of G-C base pairs, and this results in an elevated melting temperature (10). Conclusion: RNA thermometers represent a simple yet elegant mechanism for controlling temperature-dependent gene expression and may be more widespread among pathogenic bacteria that interact with mammalian hosts than is currently known. See also:  MicroRNA Stability…

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Hydrogen-atom energy in DNA base pairs

See also: Consciousness is simply food rearranged Role of Double Hydrogen Atom Transfer Reactions in Atmospheric Chemistry Abstract excerpt:  Hydrogen atom transfer (HAT) reactions are ubiquitous and play a crucial role in chemistries occurring in the atmosphere, biology, and industry. My comment: The link from physics to chemistry and the conserved molecular mechanisms of biologically-based RNA-mediated cell type differentiation has been the focus my works for more than 20 years, even before I knew what I would need to explain…

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RNA methylation

This is a brief history of events that led me to found the domain RNA-mediated.com with some follow-up on the latest news about cell type differentiation In 2012, I attended this minisymposium 006.Transcribing Memories: New Mechanisms of Activity-Regulated Gene Expression and Their Roles in Experience-Dependent Plasticity. Description: Activity-regulated gene transcription is essential for orchestrating the gene expression programs that drive experience-dependent plasticity of neural circuits. Recent studies have not only vastly expanded our understanding of the mechanisms that mediate activity-regulated…

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Countdown to Genetics and Genomics

RNA-mediated physics, chemistry, and molecular epigenetics (5) 5/10/16 Focus: Functional Implications of Human-Specific Changes in Great Ape microRNAs RNA-mediated physics, chemistry, and molecular epigenetics (4) 5/9/16 Focus: Femtosecond structural dynamics drives the trans/cis isomerization in photoactive yellow protein RNA-mediated physics, chemistry, and molecular epigenetics (3) 5/9/16 Focus: Microtargeting cancer metabolism: opening new therapeutic windows based on lipid metabolism RNA-mediated physics, chemistry, and molecular epigenetics (2) 5/6/16 Focus: Micron-scale plasma membrane curvature is recognized by the septin cytoskeleton RNA-mediated physics, chemistry,…

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RNA-mediated physics, chemistry, and molecular epigenetics (4)

Femtosecond structural dynamics drives the trans/cis isomerization in photoactive yellow protein 5/6/16 Summary excerpt: Visualizing a response to light Many biological processes depend on detecting and responding to light. The response is often mediated by a structural change in a protein that begins when absorption of a photon causes isomerization of a chromophore bound to the protein Article excerpt: Ultrafast fluorescence and transient absorption spectroscopy of PYP have shown that excited state decay is multi-phasic (3, 5, 39). The fast…

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RNA-mediated physics, chemistry, and molecular epigenetics (3)

Microtargeting cancer metabolism: opening new therapeutic windows based on lipid metabolism reported as: Using microRNAs to target cancer cells By Dawn Hayward Conclusion:  MicroRNAs stand out from conventional gene-therapy-based approaches and have a niche in lipid metabolism. They can be designed specifically to target a gene and serve as modulators rather than on/off switches. Increased lipid formation and breakdown in cancer cells creates vulnerability that might be taken advantage of by microRNAs. In addition, cancer as a whole involves a…

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Virus-driven sex differences?

DNA methylation on N6-adenine in mammalian embryonic stem cells Excerpt: DNA methylation is a crucial component of epigenetic regulation that controls many important aspects of mammalian biology, such as imprinting, X chromosome inactivation and tumorigenesis1, 2. My comment: Nutrient-dependent RNA-directed DNA methylation links RNA-mediated amino acid substitutions to protein folding chemistry during thermodynamic cycles of energy dependent protein biosynthesis and degradation. Sex of a baby? Ancient virus makes the call Excerpt: …in other organisms, such as C elegans and the…

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