DNA methylation

Confusing effects and affects of visual input

Their report indicates that these researchers never learned to differentiate between epigenetic effects on RNA-mediated cell type differentiation compared to the experience-dependent affects on behavior of amino acid substitutions. Experience Affects Critical Period Plasticity in the Visual Cortex through an Epigenetic Regulation of Histone Post-Translational Modifications Excerpt: We show that the early exposure of rat pups to enriching environmental conditions accelerates the critical period for plasticity in the primary visual cortex, linking this effect to increased histone acetylation, specifically at…

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Energy-dependent purpose vs teleophobic telorexia

I’m not getting any responses to an attempt to discuss  On epigenetics: We are not just our DNA. That suggests I should use the claims and my attempt to discuss them in a blog post. If no one else wants to discuss the links from atoms to ecosystems in the diagram above, at least there will be a record to show they ignored them, again. James V. Kohl March 11, 2016 at 9:55 am Thanks for reporting on the symposium…

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Energy dependent RNA-mediated immunity (5)

Manfred Eigen (born May 9, 1927) is a German biophysical chemist who won the 1967 Nobel Prize in Chemistry for work on measuring fast chemical reactions. People are still touting his neo-Darwinian nonsense nearly 50 years later. It sometimes seems that nothing is known to the pseudoscientists about how the RNA-mediated innate immune system links nutrient-dependent RNA-mediated DNA repair to supercoiled DNA and  protection against virus-driven entropy. Supercoiled DNA links ecological variation to ecological adaptation and transgenerational epigenetic inheritance in…

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Effects on invertebrate GnRH and affects on primate behavior

Introduction: Energy-dependent changes in hydrogen-atom transfer in DNA base pairs in solution have again been linked to hormone-organized and hormone-activated behaviors by the conserved molecular mechanisms we detailed in the molecular epigenetics section of our 1996 Hormones and Behavior review. The practical application of those details has been reported in the context of this article, published in the New England Journal of Medicine. Effects of Testosterone Treatment in Older Men Daily Diagnosis is emailed each weekday to members of the…

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Creating gravity, nucleic acids, receptors, and supercoiled DNA (2)

See also: Creating gravity, nucleic acids, receptors, and supercoiled DNA Scientists make first direct detection of gravitational waves Excerpt: Almost 100 years ago today, Albert Einstein predicted the existence of gravitational waves — ripples in the fabric of space-time that are set off by extremely violent, cosmic cataclysms in the early universe. With his knowledge of the universe and the technology available in 1916, Einstein assumed that such ripples would be “vanishingly small” and nearly impossible to detect. My comment:…

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Neuroscience Virtual Event vs AAAS Symposium

Neuroscience Virtual Event Abstract Submission Poster title: From hydrogen-atom transfer in DNA base pairs to ecosystems (March 16-17, 2016) Abstract: This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on DNA base pairs in solution and RNA-mediated amino acid substitutions to chromosomal rearrangements via pheromone-controlled changes in the microRNA / messenger RNA balance. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent & pH-dependent protein folding; experience-dependent receptor-mediated behaviors,…

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Ecological genomics: teleophobes respond (too late)

Forecasting Ecological Genomics: High-Tech Animal Instrumentation Meets High-Throughput Sequencing Conclusion: Twenty years ago, an essay about sequencing genomes and remotely tracking animals across the globe in real time would have been the subject of science fiction. In 2015, there are over 50,000 animals being tracked [12], and single research groups now sequence dozens, up to hundreds, of individual genomes [17,82]. By embracing new technology and integrating these data streams into an ecological genomic framework (Fig 1), we are now poised…

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MicroRNA-mediated RNA epigenetics

RNA Epigenetics DNA isn’t the only decorated nucleic acid in the cell. Modifications to RNA molecules are much more common and are critical for regulating diverse biological processes. Excerpt: …specific alternative splicing types, such as intron retention, exon skipping, and alternative first or last exon usage, were highly correlated with m6A decoration. And silencing the m6A methylating protein METTL3 affected global gene expression and alternative splicing patterns in both human and mouse cells.2 My comment: “Silencing” a protein effects global…

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RNA methylation, RNA-directed DNA methylation, learning and memory

sink testing Lab medicine The illegal practice of providing false test results on clinical specimens–eg, vials of blood, urine specimens, that were deliberately discarded–ie, down the sink, without actually testing them Pylori Story #1: Acid Attack Pylori Story #2: Journey to the Center of the Stomach The “Modern Synthesis” is analogous to sink testing in the medical laboratory. See for example: Replace the Modern Synthesis (Neo-Darwinism): An Interview With Denis Noble Excerpt: [W]hat Haldane, Fisher, Sewell Wright, Hardy, Weinberg et…

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Epigenetic (re)programming of behavior (3)

Bipolar drug turns foraging ants into scouts Excerpt: “DNA methylation has become nearly synonymous with epigenetics,” says Brendan Hunt, an insect geneticist at the University of Georgia in Griffin. “This research brings needed attention to the importance of other epigenetics marks, like histone modifications.” “We finally have a mechanism to understand ‘nurture’ in molecular terms,” says Gene Robinson, a geneticist at the University of Illinois, Urbana-Champaign, who studies caste determination in honey bees. The ant study, he adds, highlights “how…

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