DNA methylation

Epimutation.com: a domain of confusion

See: Epimutation.com Currently, there is no content. When content is added, it will almost undoubtedly further the cause of confusion that evolutionary theorists must use in attempts to prevent serious scientists from Combating Evolution to Fight Disease. Serious scientists use what is currently known about biologically-based cause and effect. Prepare yourself for more pseudoscientific nonsense about epimutations. Until then, see this: Researchers investigate effect of environmental epigenetics on disease and evolution Excerpt 1) …environmental factors are having an underappreciated effect…

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Viruses, amino acids, and somatic cell types (2)

Quantitative and functional interrogation of parent-of-origin allelic expression biases in the brain Excerpt: The RNA-seq data enabled us to detect a positive correlation between developmental changes in the magnitude of parental biases and overall gene expression for most imprinted genes. Conclusion: At the level of the organism, our data uncover how paternal and maternal alleles of Bcl-x make vastly different contributions to brain development, a result that has profound implications for the analysis of parentally-inherited polymorphisms in human health. Reported…

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RNA-mediated terms of virus-induced en-deer-ment

  KarmaWarrior Level – Oh Deer Posted by Stanton Warriors on Friday, August 1, 2014 My comment: This reminds me of a reported incident from: Gibbons, D.L. (1989) Unusual case: Sex in the woods. Medical Aspects of Human Sexuality, 23,10(Oct):63.“Cindy, who was menstruating… had gone alone to a portable commode hidden in a thicket to change her tampon, unaware that a young stag was nearby… Smelling her menstrual secretions, the deer became sexually aroused. He bounded through the trees and…

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Becoming biologically informed (3)

See also: Becoming biologically informed and Becoming biologically informed (2) Now available for free: New Perspectives on microRNA in Disease and Therapy (July 22, 2015) My comments: Perhaps someone will correct me if I am wrong. The microRNAs do not appear to participate in a direct response to viruses. But, over long periods of time they may fine-tune the microRNA/messenger RNA balance in the organized genomes of all living genera.  If so, the changes are manifested in morphology and in…

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Easy editing: Reinventing our RNA world

Easy DNA Editing Will Remake the World. Buckle Up. Excerpt: Most present-day animals and plants defend themselves against viruses with structures made out of RNA. My comment: RNA-mediated gene duplication and fixation of  RNA-mediated amino acid substitutions in the context of the nutrient-dependent physiology of learning, memory, and reproduction links the biophysically constrained chemistry of cell type differentiation in all genera via conserved molecular mechanisms. That fact was integrated into the science fiction novel Blood Music by Greg Bear, who…

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Riding the wrong direction

Riding the Evolution Paradigm Shift With Eugene Koonin Excerpt: The entire evolution of the microbial world and the virus world, and the interaction between microbes and viruses and other life forms have been left out of the Modern Synthesis… Excerpt: [T]he entire ideology of personalized medicine should be taken with many grains of salt. My comment: Personalized medicine links the conserved molecular mechanisms of biologically-based cause and effect from nutrient-dependent RNA-mediated gene duplication to RNA-mediated amino acid substitutions, which differentiate…

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RNA-mediated gene duplication, fixation, and ecological adaptation

Chromosomal Arrangement of Phosphorelay Genes Couples Sporulation and DNA Replication Excerpt: The simplicity of this coordination mechanism suggests that it may be widely applicable in a variety of gene regulatory and stress-response settings. Reported as: Bacteria use DNA replication to time key decision Excerpt: “Successful sporulation requires two complete copies of the bacterial chromosome, so coordination between the sporulation decision and the completion of DNA replication is very important,” Narula said. “A good analogy might be a semester-long course in…

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MicroRNA – controlled ecological adaptations

A post-transcriptional mechanism pacing expression of neural genes with precursor cell differentiation status Introduction: Eukaryotic gene expression is an intricate balancing act between transcription and post-transcriptional steps of RNA metabolism. Developmental readjustment of this balance allows large cohorts of genes to be expressed in cell- and tissue-specific manner. Among other regulators, RNA-binding proteins (RBPs) provide an important means for modulating RNA processing and turnover in the context of cellular differentiation1, 2, 3, 4. For example, downregulation of the ubiquitously expressed…

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“New” epigenetic mechanism for lifelong learning?

Critical Role of Histone Turnover in Neuronal Transcription and Plasticity Reported as: Lifelong learning is made possible by recycling of histones, study says Also reported as: New epigenetic mechanism revealed in brain cells Excerpt: In humans, researchers used a technique called 14C/12C bomb pulse dating to measure turnover. The technique is based on the fact that high levels of radioactive carbon (14C) were released into the atmosphere during the 1950s and 1960s, when open-air nuclear bomb testing occurred following the…

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The sum of our RNA-mediated parts

The Sum of Our Parts Excerpt: …it is the microbiome that determines our actual exposure to the environment. Substances such as foods, drugs, and environmental chemicals—collectively termed xenobiotics—must first pass through the layers of microbiota on the skin, in the gut, and in the airways where, depending upon the microbes present, the chemicals will be sequestered, excluded, or metabolized before they ever enter our cells. Excerpt: Microbiome-driven immunomodulation occurs via cell surface receptor signaling—involving Toll-like and NOD-like (nucleotide-binding oligomerization domain)…

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