DNA

2018 March for Science vs microRNAs (2)

April 18, 2018
James Kohl
Adaptations, Autophagy, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Physics, RNA Directed, RNA interference, RNA-directed DNA methylation, RNA–Mediated Epigenetic Heredity
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The anti-entropic virucidal energy of sunlight on contact with water has been linked from the creation of ATP synthase to the creation of ATP and to the creation of RNA. Energy-dependent RNA-mediated DNA repair has been linked to biophysically constrained viral latency via the creation of microRNAs and feedback loops linked to the food energy-dependent microRNA-mediated physiology of reproduction. The physiology of energy-dependent pheromone-controlled reproduction biophysically constrains viral latency in the context of the creation of the innate immune system…

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Autophagy is the antiphage defense strategy (2)

January 17, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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2/15/17 Energy as information and constrained endogenous RNA interference (video) The 6.46 minute-long technical presentation (above) from the Precision Medicine Virtual Conference is difficult to understand.Thus, 10 months later, Nik Willmore asked: 12/24/17 What are your insights into CRISPR and mTOR, for a young audience? I’m not mocking you…yet, Humpty Dumpty. What is the basis of your unifying principle? Vibration? Bohmian morphogenetic fields? Modified Darwin? God? –Nik Willmore @nikwillmore 12/25/17 Replying to @nikwillmore @jhewitt123 God created the anti-entropic virucidal energy of sunlight and…

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A Mathematical Model Links Quantum Physics to Quantum Souls (2)

January 4, 2018
James Kohl
Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity, Variations
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See for review: A Mathematical Model Links Quantum Physics to Quantum Souls (1) See for comparison: Zaugg Lab We are applying and developing computational biology tools for integrating large-scale biological ‘omics data to address questions in personalised genomics. The Zaugg Lab ignores everything known to serious scientists about energy-dependent top-down causation, which is the only way to link quantum physics to biophysically constrained biologically-based biodiversity. Watch them try to do that with a mathematical model, instead. Loops in DNA affect which proteins are coded …

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The Origin of Information (4)

August 4, 2017
James Kohl
Adaptations, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Summary: Others have learned that the energy in a hydrogen atom must be linked to all biodiversity on Earth. The question is: “Where did the energy in the hydrogen atom come from?” See: The Origin of Information (3) Finally, someone is asking questions that can be summarized in one question (see below). Until now, on the International Society for Human Ethology’s Yahoo group, and elsewhere, the moderator: Jay R. Feierman has prevented the dissemination of accurate information on this topic.…

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From E. coli to monkeys and mankind: Theories vs models (2)

May 28, 2017
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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Dedicated to Dr. Tom Jordan and Priscilla Jordan on the day of their retirement from the Baptist ministry, May 28, 2017. They always encouraged me to learn more about the “Laws of Biology” and link the Laws from energy as information to all biodiversity on Earth via the physiology of reproduction. See also: From E. coli to monkeys and mankind: Theories vs models High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding (5/23/127) …changes in observed association…

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UV light and non-coding RNA

May 9, 2017
James Kohl
Adaptations, Alternative Splicings, biophotonics, Ecology, Model Organisms, RNA methylation, RNA-directed DNA methylation, Variations
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UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene …these events underlie a switch to expression of short mRNA isoforms and preferential use of alternative last exons in a number of genes, including ASCC3. Intriguingly, the switch between ASCC3 isoforms occurs on more than one level, in that the long mRNA isoform encodes a protein, functioning in the context of the ASCC complex and required for maintaining transcriptional suppression in the late stages of…

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Sal Giardina: apologetics revisited

March 27, 2017
James Kohl
Adaptations, Alternative Splicings, Autophagy, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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March 26, 2017 Sal Giardina wrote: “James, I appreciate your responding to my posts but I would prefer that your input would be related to the content of the post.” My reply: If you do not want people to learn how my claims are linked to yours, please tell me that you intend to continue with apologetics rather the concept of energy as information. Apologetics: … the religious discipline of defending or proving the truth of religious doctrines through systematic…

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Confusing effects and affects of visual input

March 24, 2016
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Their report indicates that these researchers never learned to differentiate between epigenetic effects on RNA-mediated cell type differentiation compared to the experience-dependent affects on behavior of amino acid substitutions. Experience Affects Critical Period Plasticity in the Visual Cortex through an Epigenetic Regulation of Histone Post-Translational Modifications Excerpt: We show that the early exposure of rat pups to enriching environmental conditions accelerates the critical period for plasticity in the primary visual cortex, linking this effect to increased histone acetylation, specifically at…

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Neuroscience Virtual Event vs AAAS Symposium

February 4, 2016
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Neuroscience Virtual Event Abstract Submission Poster title: From hydrogen-atom transfer in DNA base pairs to ecosystems (March 16-17, 2016) Abstract: This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on DNA base pairs in solution and RNA-mediated amino acid substitutions to chromosomal rearrangements via pheromone-controlled changes in the microRNA / messenger RNA balance. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent & pH-dependent protein folding; experience-dependent receptor-mediated behaviors,…

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Despicable fools?

January 27, 2016
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Metamaterial Offers Simpler Route to Slow Light Excerpt: Light is generally accepted to travel at a constant speed, but its group velocity can be slowed by passing through refractive materials. Compared to its top speed in a vacuum, light travels slightly slower in air and slightly slower still in water. These changes in speed are fairly insignificant, however. My comment: I doubt that any member of the RNA society thinks that the changes that link the de novo creation of…

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