DNA

Hydrogen-atom transfer in DNA base pairs (5)

Can Anybody Actually Win The Evolution 2.0 Prize? January 18, 2016 at 9:44 pm In an invited review of nutritional epigenetics, I linked atoms to ecosystems without the pseudoscientific nonsense touted by neo-Darwinists. Kohl, James V. (2014): Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems. The invited submission was returned without review. When I provide all the details for the origin of the DNA code, what prevents the submission from being rejected without comment? January 18, 2016 at 11:13 pm …

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Hydrogen-Atom Transfer in DNA Base Pairs (2)

See also: Hydrogen-Atom Transfer in DNA Base Pairs Ultrafast vibrational dynamics of the DNA backbone at different hydration levels mapped by two-dimensional infrared spectroscopy Conclusions excerpt: …the hydration level is substantially below a bulk water environment existing under physiological conditions. To get insight into this biologically most relevant scenario, future work will address the behavior of longer DNA helices and RNA with sodium counterions, embedded in bulk liquid water. Such work will also help to assess the role of long-range…

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Theorists can’t understand biology

See also: Neuroplasticity Thanks to Teresa Binstock for calling my attention to this:   Thanks to Anna Di Cosmo for calling the attention of others to this: My comment: Attempts to explain the “binding problem” of integration in the context of ecoimmunology and disease ecology compared to emergence and evolution are examples of how much pseudoscientific nonsense has been accepted and touted in the context of the neo-Darwinian “Modern Synthesis.” For comparison, serious scientists have detailed a model of top-down…

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Skip the politics; embrace the facts

It’s Not Brain Surgery, Ben Carson Excerpt: …“Heal Inspire Revive,” invokes an image of him pounding on the chest of a pulseless America. Whether or not he actually knows how to handle a crash cart of that size, many voters don’t seem to doubt that he can. And he doesn’t doubt it either. My comment: I do not expect anyone who understands what is currently known about how physics and chemistry are linked to the biophysically constrained conserved molecular mechanisms…

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Exosomes and the RNA-mediated future of medicine (2)

GDNF-Transfected Macrophages Produce Potent Neuroprotective Effects in Parkinson’s Disease Mouse Model Excerpt: …genetically-modified macrophages released exosomes with incorporated GDNF that may facilitate GDNF transport into the target cells and preserve it against degradation. published 9/17/14 and reported on 9/11/15 as: Smart cells teach neurons damaged by Parkinson’s to heal themselves Excerpt: In addition to delivering GDNF, the engineered macrophages can “teach” neurons to make the protein for themselves by delivering both the tools and the instructions needed: DNA, messenger RNA…

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Creating genes and species

The Octopus Genome: Not “Alien” but Still a Big Problem for Darwinism by Casey Luskin, August 24, 2015 Excerpt: Whenever you see “de novo” origin of a gene invoked, you know that evolutionary biologists lack any explanation for how that gene arose. My comment: I tend to use the experience-dependent “de novo” creation of olfactory receptor genes as an example of how RNA-mediated events link physics, chemistry, and biology from atoms to ecosystems via the conserved molecular mechanisms of biophysically…

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Olfaction & the octopus and human genomes (2)

Darwinian evolution in the light of genomics Eugene Koonin excerpt: The distribution of evolutionary rates across sets of orthologous genes, the distribution of the sizes of paralogous gene families, the negative correlation between the expression level and the sequence evolution rate of a gene, and other relationships between key evolutionary and phenomic variables seem to be genuine universals of evolution. The simplicity of these universal regularities suggests that they are shaped by equally simple, fundamental evolutionary processes, rather than by…

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The stability of organized genomes (3)

See also: The stability of organized genomes; The stability of organized genomes (2) Nutrient-dependent/pheromone-controlled adaptive evolution: a model Excerpt from 6/14/13  …the epigenetic ‘tweaking’ of the immense gene networks that occurs via exposure to nutrient chemicals and pheromones can now be modeled in the context of the microRNA/messenger RNA balance, receptor-mediated intracellular signaling, and the stochastic gene expression required for nutrient-dependent pheromone-controlled adaptive evolution. Global relationships in fluctuation and response in adaptive evolution Preprint pdf opens here Excerpt: It should…

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Epimutation.com: a domain of confusion

See: Epimutation.com Currently, there is no content. When content is added, it will almost undoubtedly further the cause of confusion that evolutionary theorists must use in attempts to prevent serious scientists from Combating Evolution to Fight Disease. Serious scientists use what is currently known about biologically-based cause and effect. Prepare yourself for more pseudoscientific nonsense about epimutations. Until then, see this: Researchers investigate effect of environmental epigenetics on disease and evolution Excerpt 1) …environmental factors are having an underappreciated effect…

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Becoming biologically informed (3)

See also: Becoming biologically informed and Becoming biologically informed (2) Now available for free: New Perspectives on microRNA in Disease and Therapy (July 22, 2015) My comments: Perhaps someone will correct me if I am wrong. The microRNAs do not appear to participate in a direct response to viruses. But, over long periods of time they may fine-tune the microRNA/messenger RNA balance in the organized genomes of all living genera.  If so, the changes are manifested in morphology and in…

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