DNA

Mutagenesis: Replacing facts with theories

Never mind the selfish gene – ribosomes are the missing link Excerpt: “All cells share three organelles, or internal structures, besides gene-containing chromosomes: ribosomes which contain the machinery for translating genetic information into the proteins that perform the cell’s work; a cell membrane that selectively permits materials in and out; and acidocalcisomes, which store and regulate the ions that drive the chemical reactions of life.” In his criticisms of my model of cell type differentiation, Andrew Jones (aka anonymous_9001 in…

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Unified nutritional and molecular mechanisms

Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits Article image: Excerpt: “…unifying nutritional and molecular mechanisms remain elusive.” Reported as Molecular mechanism behind health benefits of dietary restriction identified Excerpt 1) “Dietary restriction is a type of intervention that can include reduced overall food intake, decreased consumption of particular macronutrients such as protein, or intermittent bouts of fasting. It is known to have beneficial health effects, including protection from tissue injury and improved metabolism. It has also been…

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Model organisms: the birds and the bees

Bird Genomes Abound Scientists complete the largest-ever comparative genomic study of birds. By Ruth Williams | December 11, 2014 Excerpt: “Birds are model organisms for a number of human behaviors and conditions—For example, Jarvis compares vocal learning in birds and humans—so determining the genetic basis of such traits requires genetic history.” My comment: Honeybees are model organisms for “…human immunity, disease resistance, allergic reaction, circadian rhythms, antibiotic resistance, the development of the brain and behavior, mental health, longevity, diseases of…

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Chemical ecology and RNA-mediated control of DNA loops

DNA Loop-the-Loops A new full-genome map indicates how DNA is folded within the nuclei of human cells.By Kate Yandell | December 11, 2014 Excerpt: “…many loops were conserved among cell types, and even between mice and humans. But others seemed to drive cell type-specific gene expression patterns.” My comment to The Scientist Magazine: Nutrient-dependent/pheromone-controlled adaptive evolution: a model. Excerpt: “A form of GnRH associated with sexual orientation in yeasts links control of the feedback loops and developmental processes required for…

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Atoms to ecosystems: Evolutionary theory vs the coelacanth

Biodiversity: Life ­– a status report “Species are disappearing quickly — but researchers are struggling to assess how bad the problem is.” I want to eliminate some of the researcher’s struggles, but a moderator at Nature has blocked all my comments for several months, perhaps permanently. I think my past comments on articles, like this one, explain why other comments are blocked. In the past, I commented each time I saw a misrepresentation of biologically-based cause and effect. The misrepresentations…

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Jumping back: Science or Pseudoscience?

Daily Comment November 21, 2014 European Science’s Great Leap Backward By Michael Specter Excerpt 1) “When politicians reject verifiable data and reputable research and rely instead on politics or desire, the results can be devastating.” Excerpt 2 with my emphasis) “…scientific organizations from around the world… have strongly endorsed the safety of G.M. foods. (It should be noted that the U.S. can claim no superiority in our approach to evidence-based science, as demonstrated by the fact that nearly half of…

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Glycine and GnRH: Am I being pedantic?

Posted to the FB page on 12/3/14 at Skeptics; Atheists; Realists; Agnostics; Humanists Stephen Hawking and Brian Cox take part in Monty Python sketch – video Excerpt: “I think you are being pedantic.” My comment: Some people may think I am being pedantic. My focus is not on physics; it is on the role of GnRH in cell type differentiation. My focus now extends from what is known about quantum physics, quantum smell, chirality, quantum biology, and quantum consciousness. What is known about chirality…

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Dual genomes: exposing the evolution industry

Multiple haplotype-resolved genomes reveal population patterns of gene and protein diplotypes Excerpt: “The CDP showed a significant overrepresentation of certain gene ontology (GO) groups (global tests Po0.001–0.009), using the programme FUNC23 (Methods). These groups included GPCRs, in particular olfactory receptors (ORs), and other membrane and cell-surface proteins, as well as proteins related to the immune system, such as the MHC (Class I and II), and drug metabolism…” My comment: Biodiversity “…converges upon a ‘common diplotypic proteome (CDP)’, a distinctive subset…

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One test of bioenergetic health?

Success of new-generation metabolo-therapies in personalized medicine depends on measuring bioenergetic health Excerpt: “In one test, a comprehensive measure of energetic health, or its disease-related deterioration, can now be made. The prognostic and diagnostic value of bioenergetic measurements in patients is still unknown, but recent findings support an emerging concept that circulating leukocytes and platelets can serve as the “canary in the coal mine” by acting as early sensors or predictive biomarkers of metabolic function under conditions of chronic stress…

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Thermodynamic constraints and ecological adaptations sans evolution

Relationship between protein thermodynamic constraints and variation of evolutionary rates among sites Excerpt: “…a two-variable model that combines stability and stress signi ficantly improves predictions. Therefore, both the overall stability [symbol] and the stress [symbol] seem to capture distinct thermodynamic constraints on protein evolution.” My comment: Proteins do not evolve. Nutrients are required. Metabolism of nutrients to species-specific pheromones controls the physiology of reproduction in species from microbes to man. The nutrient-dependent pheromone-controlled physiology of reproduction enables epistasis via nutrient-dependent RNA-directed DNA…

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