ecological speciation

Ricki Lewis’ Time Machine (4)

Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan Excerpt: The signal we observe is driven by rs429358, a non-synonymous Cys112Arg variant, which defines the ε4 allele and which has not previously been shown to be the causal variant influencing lifespan. See also: Gorilla Genome 2.0: Lessons for the Clinic? Excerpt: VARIANTS OF UNCERTAIN SIGNIFICANCE With phrases such as “settled science” and “scientific proof” part of the lexicon, it’s little wonder that health care consumers expect…

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Ricki Lewis’ Time Machine

Can a Quirky Chromosome Create a Second Human Species? Excerpt 1) The first departure from the common house mouse (Mus musculus) was the “tobacco mouse” (Mus poschiavinus), described in 1869 from specimens trapped in a tobacco factory in Valle di Poschiavo, Switzerland. They had big heads and small, dark bodies. Excerpt 2) I spoke to Bear back in 2004, again for The Scientist (a mechanism for the rapid extinction of a dedicated freelance writer is a change in editor-in-chief). Greg Bear is…

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The radical pair mechanism of ecological speciation

The radical pair mechanism and the avian chemical compass: Quantum coherence and entanglement Excerpt: Radical pairs are usually produced as short-lived intermediates through decomposition, electron transfer, or hydrogen transfer reactions from singlet or triplet excited states. My comment: The radical pair mechanism appears to be another link from nutrient energy-dependent hydrogen-atom transfer in DNA base pairs to ecological speciation. However, the hydrogen-atom transfer in DNA base pairs mechanism seems to have gone unrecognized despite this report. Induction of micronuclei and superoxide production…

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Ecological adaptations you cannot live without

Follow up to: Stress-perturbed mitochondrial dysfunction Summary: Bruce McEwen and others are taking the concept of RNA-mediated amino acid substitutions in cell type differentiation to a new level. They will force neo-Darwinian theorists to differentiate between mutations and amino acid substitutions. After February 14, 2016, if you still don’t know the difference, you may be subjected to ridicule by serious scientists who know how to link atoms to ecosystems in the context of biologically-based cause and effect. Also, the “Precision…

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A two-faced protein enables RNA-mediated DNA repair (4)

See also: A two-faced protein enables RNA-mediated DNA repair (3) The importance of DNA repair to heritability cannot be understated. Theorists who think in terms of mutations and evolution are biologically uninformed and may never have learned anything about DNA repair. Serious scientists are overloaded with information and are not likely to try to explain facts about biologically based cause and effect to theorists. November, 2015 An individual-based diploid model predicts limited conditions under which stochastic gene expression becomes advantageous My…

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Positive feedback loops and epigenetic traps

Transcription factor trapping by RNA in gene regulatory elements Conclusion: …bidirectional transcription of active enhancers and promoters evolved, in part, to facilitate trapping of TFs at specific regulatory elements. The model also suggests that transcription of regulatory elements produces a positive-feedback loop that may contribute to the stability of gene expression programs in cells. The contribution of this TF trapping mechanism to cellular regulation has yet to be established but will be important to elucidate in future studies because much…

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Stress-perturbed mitochondrial dysfunction (2)

See also: Stress-perturbed mitochondrial dysfunction Biologically uniformed science idiots either refuse to discuss facts or try to bury them beneath the pseudoscientific nonsense of their ridiculous claims. Study connects mitochondria to psychological stress response and species resilience See the discussion of this news report on the Neuroscience FB group. With one exception, I’ve included only my own comments because my comments are tractable across what is currently known to serious scientists at a time when anonymous fools hope to disrupt…

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Xist-ing on planet Earth

Sex Differences in the Brain (revisited) A comment that was complementary led me to add this: Ideas about evolutionary processes that automagically led to sex differences in cell types can be dissmissed in the light of experimental evidence of biologically-based cause and effect. Since 1996, for example, serious scientists have known about the role of Xist in chromosome inactivation. See also, from 2015:An Xist-activating antisense RNA required for X-chromosome inactivation In our Hormones and Behavior review we (TB) wrote: “Genomic-imprinting…

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Ecology replaces the extended evolutionary synthesis

The extended evolutionary synthesis: its structure, assumptions and predictions Excerpt 1) “We label this interpretation the ‘extended evolutionary synthesis’ (EES) but emphasize, contrary to some recent claims (e.g. [10]), that the EES is a developing line of contemporary evolutionary thought that exists within the field, and not a denial of the value of past frameworks or of progress in evolutionary biology. To some readers, the use of the EES label might appear grandiloquent but, as we will show, the significance…

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Chance mutations — not natural selection

A Surprise for Evolution in Giant Tree of Life Excerpt (with my emphasis): Each variant adapted to suit a different ecological niche. But Blair Hedges, a biologist at Temple University in Philadelphia, has proposed a provocative alternative: Adaptation had little to do with it. It was simply a matter of chance and time. See also: The Surprising Origins of Evolutionary Complexity July 16, 2013 Excerpt: Some argue that life has a built-in tendency to become more complex over time. Others…

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