ecological variation

Origin and evolution of the genetic code

Origin and evolution of the genetic code: the universal enigma Excerpt: …it appears essentially certain that the evolution of the code involved some combination of frozen accident with selection for error minimization. My comment: This claim from 2009 failed to address anything currently known to serious scientists about the Schrodinger’s claim from 1944, in What is Life? Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state…

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Blood test links atoms to ecosystems

New blood test may expand scope of liquid biopsies Excerpt: During cell death, the DNA gets chopped into small pieces by enzymes that like to cut in the easily accessible, unprotected sections of DNA in between the nucleosomes. My comment: The test links ecological variation to nutrient-dependent RNA-mediated DNA repair via microRNAs and adhesion proteins. The adhesion proteins link supercoiled DNA to protection from virus-driven entropy in the organized genomes of all living genera. The organized genomes are linked from…

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Juvenile hormone links atoms to ecosystems

A comparative perspective on epigenetics Excerpt 1) …adaptation and evolution emerge through network-wide responses to change at all levels of biological organisation, from proteins and membranes to organelles and cells, rather than being driven by individual genes. ‘Active causation resides in the networks, which includes many components for which there are no DNA templates’, says Noble, concluding that this novel approach provides ‘an integrated systems view of evolution’. Excerpt 2) ‘Active causation resides in the networks, which includes many components…

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Perry Marshall: too much information for atheist PZ Myers

Atheist PZ Myers Debates Perry Marshall Darwinism vs. Evolution 2.0 on “Unbelievable?” Excerpt: Contrary to what PZ said, McClintock’s work is explicitly about cells engineering solutions! That is her point. My comment: Perry Marshall shows how difficult it is to discuss biological facts with those who are biologically uninformed. PZ Myers ignores everything known about how the innate immune system is designed to ensure cell type stability and the nutrient-dependent stability of organized genomes. That nutrient-dependent stability is maintained across…

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Did Dobzhansky see the UV light of creation?

Analemma. The sun’s position in the sky, photographed from the same location at the same time of day throughout a year, forms an analemma. This shows the sun’s apparent swinging from its northernmost position, at the analemma’s uppermost point, at summer solstice, to its southernmost position/lowest point, at winter solstice. My comment: Does this remind anyone else of a one-sided nonorientable surface obtained by cutting a closed band into a single strip with linked ends that can be used to…

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RNA-mediated theory killers (2)

RNA-mediated theory killers… This is a continuation that will become a series that links the million dollar paradox to the $100,000 prize offered for finding the origin of information at Evolution 2.0, which obviously will be a continuation of Schrodinger’s claims and Dobzhansky’s claims along with the claims of others I have repeatedly mentioned here. Critical Role of Histone Turnover in Neuronal Transcription and Plasticity Reported as: Lifelong learning is made possible by recycling of histones Excerpt: “Histones and their…

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A two-faced protein enables RNA-mediated DNA repair (4)

See also: A two-faced protein enables RNA-mediated DNA repair (3) The importance of DNA repair to heritability cannot be understated. Theorists who think in terms of mutations and evolution are biologically uninformed and may never have learned anything about DNA repair. Serious scientists are overloaded with information and are not likely to try to explain facts about biologically based cause and effect to theorists. November, 2015 An individual-based diploid model predicts limited conditions under which stochastic gene expression becomes advantageous My…

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The Sherlock lab: Beneficial mutations

After he challenged me in a discussion of two works on tardigrades, Gavin Sherlock‘s comments were removed from the facebook page of Serafim Batzoglou. In the context of The genome of the tardigrade Hypsibius dujardini and Evidence for extensive horizontal gene transfer from the draft genome of a tardigrade, it quickly became clear that Gavin Sherlock knows nothing about how cell type differentiation occurs. Sherlock is the senior author of Quantitative evolutionary dynamics using high-resolution lineage tracking Excerpt: Our results…

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Positive feedback loops and epigenetic traps

Transcription factor trapping by RNA in gene regulatory elements Conclusion: …bidirectional transcription of active enhancers and promoters evolved, in part, to facilitate trapping of TFs at specific regulatory elements. The model also suggests that transcription of regulatory elements produces a positive-feedback loop that may contribute to the stability of gene expression programs in cells. The contribution of this TF trapping mechanism to cellular regulation has yet to be established but will be important to elucidate in future studies because much…

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Virus, transposon and plasmid evolution

A novel group of diverse Polinton-like viruses discovered by metagenome analysis Excerpt: This class of selfish elements is extremely widespread and might have been a hotbed of eukaryotic virus, transposon and plasmid evolution. New families of these elements are expected to be discovered. My comment: How much longer will Koonin’s group keep trying to convince biologically uninformed science idiots that selfish elements evolve or that species evolve? All serious scientists know that ecological variation leads to ecological adaptation via nutrient-dependent…

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