ecological variation

Human pheromone deniers: What’s next?

Adapted from Human pheromones: What should these idiots do next? RNA-directed DNA methylation and RNA-mediated gene duplication and RNA-mediated amino acid substitutions link the nutrient-dependent physiology of pheromone-controlled reproduction to morphological and behavioral phenotypes in species from microbes to humans. Why would any serious scientist claim that there is a need to find human pheromones? Does any serious scientist not realize that the molecular mechanisms that link ecological variation to ecological adaptation must be the same in all living genera?…

Read More

Mystery machine vs model (2)

See: Mystery machine vs model Here are links to reports that attest to the accurate representation of links from nutrient energy-dependent base pair changes to RNA-mediated amino acid substitutions and protection of organized genomes from virus-driven genomic entropy. See also: Intercellular wiring enables electron transfer between methanotrophic archaea and bacteria Re: direct interspecies electron transfer (DIET) Excerpt: HotSeep-1 comprises the genes for the biosynthesis and assembly of type IV pili, as well as large multi-haem cytochrome c proteins, both with…

Read More

Xist-ing on planet Earth

Sex Differences in the Brain (revisited) A comment that was complementary led me to add this: Ideas about evolutionary processes that automagically led to sex differences in cell types can be dissmissed in the light of experimental evidence of biologically-based cause and effect. Since 1996, for example, serious scientists have known about the role of Xist in chromosome inactivation. See also, from 2015:An Xist-activating antisense RNA required for X-chromosome inactivation In our Hormones and Behavior review we (TB) wrote: “Genomic-imprinting…

Read More

Mechanisms of stress: from genes to cancer

Biophysically constrained nutrient-dependent thermodynamic cycles of protein biosynthesis and degradation link the epigenetic landscape to the physical landscape of DNA in all living genera. Genomic stability arises in the context of a fine-tuned balance of viral microRNAs and nutrient-dependent microRNAs.  RNA-mediated gene duplication and RNA-mediated amino acid substitutions stabilize organized genomes. Nutrient-dependent microRNAs are linked by RNA-mediated amino acid substitutions from ecological variation to protection from DNA damage caused by viral microRNAs. The microRNA/messenger RNA balance links ecological variation to…

Read More

Multi-omic analysis features (SNPs, miRNA)

See also: Viral and Cellular Genomes Activate Distinct DNA Damage Responses Excerpt: Central to life is the faithful replication, inheritance, and maintenance of genomic DNA. The MRE11/RAD50/NBS1 (MRN) complex andATMplay a critical role in this biological mandate (Ciccia and Elledge, 2010). Cellular double-strand breaks (DSBs) are sensed by MRN and trigger the assembly of DNA damage response (DDR) foci that amplify global ATM signaling to induce cell-cycle arrest and DNA repair (Polo and Jackson, 2011). DNA viruses are an ancient…

Read More

Somatic hypermutation vs RNA-mediated events

Change in environment can lead to rapid evolution, researchers say Excerpt: 135 genes evolved in response to the new environment. Most of the changes in the gene expression were internal and dealt with a fish’s biological processes such as metabolism, immune function and development. My comments: 1) Journal article excerpt: “… few studies have been able to capture the initial patterns of plasticity and subsequent adaptive divergence of traits in natural populations.” All experimental evidence links physics and chemistry via…

Read More

New anti-entropic microbes

Many New Microbe Molecules Discovered in Humans Excerpt 1) Because gut bacteria live without oxygen, they need electron transfer to survive. Metabolizing amino acids allows transfer of electrons, but produces large amounts of byproducts, including phenylacetic and phenylpropionic acids. These products, unlike RiPPs are able to go into the cells and the blood stream. There are many different metabolites, only some of which are understood. Many metabolites of these are made in large quantities. Conclusion: Much of what occurs in…

Read More

RNA-mediated permanent symbioses

See also: Ecological validity vs evolutionary theory Symbiosis becoming permanent: Survival of the luckiest Published in: Proceedings of the National Academy of Sciences (PNAS) f the United States of America Excerpt: …since the 1980s, the idea that the mitochondria and plastids (chloroplasts) of eukaryotic cells arose through endosymbiosis has been about as universally accepted as such things ever are (1). However, enormous gaps remain in our knowledge about just how this happened. My comment: Symbiosis becomes permanent via RNA-mediated biologically-based…

Read More

Atomic-resolution of cell type signaling

Scientists discover atomic-resolution details of brain signaling Excerpt: Both parts of this protein complex are essential… but until now it was unclear how its two pieces fit and work together. My comment: RNA-mediated amino acid substitutions are fixed in the organized genomes of all genera via the experience-dependent de novo creation of receptors. Receptors allow nutrients into the cell types that must be differentiated to be functional. Differentiation occurs via changes in energy that link Schrodinger’s claims to quantum biology…

Read More

Iron, ferritin, thyroxine

The picture includes vegetation and rock formations. It is from Capital Reef in Utah. No serious scientist has ever suggested a link from the formations to biologically-based cause and effect outside the context of what is known about RNA-mediated events that link iron metabolism to hormones and the physiology of nutrient-dependent reproduction in all genera via amino acid substitutions. Biologically recycled continental iron is a major component in banded iron formations Excerpt: These results show that Fe sources and pathways…

Read More