ecosystem

RNA-mediated silencing (8)

Now fully complete, human genome reveals new secrets 3/31/22 reports on: A next-generation human genome sequence 3/31/22 From telomere to telomere: The transcriptional and epigenetic state of human repeat elements 4/1/22 The complete sequence of a human genome 4/1/22 Epigenetic patterns in a complete human genome 4/1/22 Complete genomic and epigenetic maps of human centromeres 4/1/22 The articles and the reporting obfuscate the fact that God’s Creation of energy-as-information links sunlight and humidity to His Creation of all biodiversity on…

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RNA-mediated silencing (7)

On 3/24/22 Reversing the miRNA -5p/-3p stoichiometry reveals physiological roles and targets of miR-140 miRNAs linked quantum coherence to coherently organized biology and quantum souls via a change in the first nucleotide in miR-140. The energy-dependent change in the first nucleotide linked Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life (4/25/20) to Functions and underlying mechanisms of miR-650 in human cancers and Identifying the oncogenic potential of gene fusions exploiting miRNAs 3/24/22 Three of the 4…

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RNA-mediated silencing (6)

See first RNA-mediated silencing (5) The AVONET database contains 11 morphological traits, such as beak shape and wing length, for 90,020 individual birds from 181 countries. It fails to link differences in uni-parental or bi-parental feeding from fixation of amino acid substitutions to the color of white-throated sparrows, which was linked to ethnic difference in skin color via chromosomal rearrangements across kingdoms via Estrogen receptor α polymorphism in a species with alternative behavioral phenotypes  1/13/14 The failure to link food…

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MicroRNA-mediated population control (5)

Visualizing a protonated RNA state that modulates microRNA-21 maturation 10/26/20 and Visualization and characterization of RNA–protein interactions in living cells 7/27/21 cannot be linked to stupid theories about the automagical emergence of energy from the cosmic void or theories that link beneficial mutations during the past billions to millions of years to our evolution from pond scum or light-activated carbon fixation in cyanobacteria. For contrast, the visualizations support this claim: “Post-transcriptional modifications, especially phosphorylation play crucial roles in regulation of…

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Pheromones protect us from viruses (6)

The Origin of Species (1859) linked the observations of Charles Darwin from his “conditions of life” to all biodiversity on Earth via the physiology of reproduction in all species. Scientific progress across disciplines has since linked his claims to an effective treatment, protonated RNA interference, for virus-driven pathology. See: Direct Observation of Protonation State Modulation in SARS-CoV-2 Main Protease upon Inhibitor Binding with Neutron Crystallography 3/23/21 Our recent neutron crystallographic study of the ligand-free SARS-CoV-2 Mpro provided direct visualization of…

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Impeaching the God of Abraham (10)

sunlight and humidity can weaken the coronavirus — Donald J. Trump 4/23/20 …there’s no medical basis for Trump’s statements about sunlight.  Jonathan Reiner, professor of medicine at The George Washington University Hospital 4/24/20 Former president Trump was absolutely correct. He linked physics and chemistry to molecular biology and healthy longevity via Haplotype-resolved diverse human genomes and integrated analysis of structural variation 2/25/21 Structural variants (SVs) —inversions, deletions, duplications, and insertions ≥50 bp in length—and their breakpoints “…are generally more depleted…

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Election day blues for fools who “voted blue” (3)

See first: Election day blues for fools who “voted blue” (2) Medical experts rip Trump’s suggestion that sunlight, disinfectants may treat coronavirus President Donald J. Trump linked God’s Creation of subatomic particles from differences in the energy of positively charged protons and negatively charged electrons to biophysically constrained healthy longevity across kingdoms via the physiology of reproduction. If Biden wins, we are a nation of losers like Jonathan Reiner. Play Biden’s stupid game, wear masks, and practice social distancing, or…

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Protonated RNA interference vs stupid theories (1)

Visualizing a protonated RNA state that modulates microRNA-21 maturation 10/26/20 …microRNA maturation efficiency may be encoded in the intrinsic dynamic ensemble of primary and precursor microRNAs, providing a potential means of regulating microRNA biogenesis in response to environmental and cellular stimuli. See for comparison:  The landscape of host genetic factors involved in immune response to common viral infections 10/27/20 Humans and viruses have co-evolved for millennia resulting in a complex host genetic architecture. Understanding the genetic mechanisms of immune response…

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From optoribogenetics to HelioRiboGenetics (5)

Wen Zhou’s group linked quantum coherence to coherently organized biology via God’s Creation of the sense of smell and the space-time continuum in Olfaction Warps Visual Time Perception Ages 10-14+ can review what is known about God’s Creation of energy-as-information and link it from HelioRiboGenetics and RNA interference to Genotypes via game play of: ION: Covalence Peptide Virulence Subatomic Periodic Cytosis Virus Expansion Ecosystem Genotype (November 2020) Alternatively, see: Announcement of the 2020 Nobel Prize in Physics Reported in Physics…

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Predicting who wins the 2017 Nobel Prizes (4)

As you wait to learn who won the 2017 Nobel Prize in Physics and in Chemistry, please consider how these recent reports will be linked from electrons to ecosystems. Every aspect must start with the creation of energy, which must link chemistry to biophysically constrained biologically based life on Earth in the context of the physiology of pheromone-controlled reproduction and Schrodinger’s claims in “What is Life? (1944). Without mention of the anti-entropic virucidal energy of sunlight, the theories of physicists…

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