EDAR variant

The concept of a species (1)

June 12, 2018
James Kohl
Adaptations, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, Nutrigenomics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, Subatomic, Variations
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In an attempt to discuss The misleading evidence that fooled scientists for decades I wrote: The concept of a species is clearly seen in the context of Darwin’s “conditions of life” and sympatric speciation. What organisms eat is linked from their physiology of pheromone-controlled reproduction to biophysically constrained viral latency and all extant biodiversity via energy-dependent changes in base pairs and fixation of amino acid substitutions in the organized genomes of species from microbes to humans. See Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From…

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EDAR V370A and sympatric speciation

May 3, 2018
James Kohl
Adaptations, Diseases & Disorders, Ecology, Model Organisms, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity, Variations
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Nick Lane and others like him refuse to reappraise their human mitochondrial DNA recombination dogma. All serious scientists know where the energy for recombination comes from. But, in his latest video clip, he touts the same unsubstantiated theoretical pseudoscientific nonsense. See the: Aeon Video: Life on earth – from mushrooms to humans and everything in between – seems enormously diverse. At the cellular level, however, almost all complex lifeforms are surprisingly similar. Why life is this way, though, remains mysterious.…

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Environmental selection is natural selection (5)

April 30, 2018
James Kohl
Adaptations, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Subatomic
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Summary: Atheistic Chinese Communists realize that vaccinations cannot protect them. Their attempts to develop a universal vaccine have failed. Bill Gates promotes vaccinations, which led us to the brink of the next pandemic. Vaccines prevent ecological adaptations in some cell types. Does Bill Gates, a non-scientist, think that people from God-fearing non-communist countries can do better than the atheistic Communists? Bill Gates calls on U.S. to lead fight against a pandemic that could kill 33 million Gates and his wife,…

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Enzyme-constrained interethnic biodiversity (1)

January 8, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Excerpt: Summaries of mutation categories: The summaries attest to the fact that human interethnic biodiversity can be linked to all biodiversity via the food energy-dependent creation of enzymes and the pheromone-controlled physiology of reproduction, which link autophagy to biophysically constrained viral latency. Immune Issue …the findings are “not a show stopper, but the field needs to know about this… Investors are stopping the Zhang-Church-Doudna show. Some were prepared to invest in energy-dependent RNA interference, which biophysically constrains viral latency.The way…

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Energy-dependent alternative splicings 1996 – 2016 (2)

December 31, 2016
James Kohl
Adaptations, Alternative Splicings, Autophagy, Ecology, Model Organisms, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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See also: Energy-dependent alternative splicings 1996 – 2016 Re: Rs3827760 is Val370Ala and EDARV370A No matter what it is called, Val370Ala may be the best example of how nutrient energy-dependent biophysically constrained pheromone-controlled viral latency protects all organisms from virus-driven energy theft and all pathology. For example, see: Genome recoding by tRNA modifications The succession of mRNA codons controls the synthesis of polypeptides through the complementarity between each of the 64 possible codon triplets and the tRNA anticodons that decode…

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Sudden death indel polymorphism

December 19, 2016
James Kohl
Adaptations, Alternative Splicings, Autophagy, biophotonics, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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An insertion/deletion polymorphism within 3’UTR of RYR2 modulates sudden unexplained death risk in Chinese populations. …different alleles of rs10692285 could alter the local structure of RYR2 mRNA and microRNA (miRNA) binding. See for comparison: Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant The differences between the 370A knockin mouse phenotypes and those of loss- and gain-of-function models emphasize the advantage of a more accurate mouse model. In this study an adaptive variant links the mouse…

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Light, behavior and autophagy, a gender-specific risk factor

November 22, 2016
James Kohl
Adaptations, Alternative Splicings, Autophagy, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation
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Structure of photosystem II and substrate binding at room temperature Excerpt: PS II, a membrane-bound multi-subunit pigment protein complex, couples the one-electron photochemistry at the reaction centre with the four-electron redox chemistry of water oxidation at the Mn4CaO5 cluster in the oxygen-evolving complex (OEC). New, detailed snapshots capture photosynthesis at room temperature The living machinery responsible for photosynthesis – while commonplace and essential to life on Earth – is still not fully understood. It is understood at every level of…

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Amino acid substitutions are not mutations

June 14, 2015
James Kohl
Adaptations, Alternative Splicings, Ecology, Human Pheromones, Model Organisms, Nutrigenomics, Pharmacogenomics, RNA Directed
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DNA data explosion lights up the Bronze Age Excerpt: …a mutation linked to thick hair and numerous sweat glands, once thought to have emerged in East Asians, was common in Scandinavians as early as 7,700 years ago — potentially revealing a connection between these groups. My comment: Serious scientists know that what was reported to be a mutation is a nutrient-dependent amino acid substitution linked to expression of a receptor, which is linked to selection of food. Modeling Recent Human…

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Nutrient-dependent microRNAs control cell types

April 6, 2015
James Kohl
Ecology, Light Energy, Model Organisms, Physics, RNA Directed
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Nutrient-dependent/pheromone-controlled adaptive evolution: a model. Excerpt: “…the epigenetic ‘tweaking’ of the immense gene networks that occurs via exposure to nutrient chemicals and pheromones can now be modeled in the context of the microRNA/messenger RNA balance, receptor-mediated intracellular signaling, and the stochastic gene expression required for nutrient-dependent pheromone-controlled adaptive evolution. The role of the microRNA/messenger RNA balance (Breen, Kemena, Vlasov, Notredame, & Kondrashov, 2012; Duvarci, Nader, & LeDoux, 2008; Griggs et al., 2013; Monahan & Lomvardas, 2012) in adaptive evolution will…

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