editing

Functionally interdependent editing and methylation

Editing and methylation at a single site by functionally interdependent activities …cytosine 32 in the anticodon loop of Trypanosoma brucei tRNAThr is methylated to 3-methylcytosine (m3C) as a pre-requisite for C-to-U deamination. Formation of m3C in vitro requires the presence of both the T. brucei m3C methyltransferase TRM140 and the deaminase ADAT2/3. Once formed, m3C is deaminated to 3-methyluridine (m3U) by the same set of enzymes. ADAT2/3 is a highly mutagenic enzyme4, but we also show that when co-expressed with…

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Dobzhansky 1973 and precision medicine (4)

See: Dobzhansky 1973 and precision medicine (3) Evidence-based medicine has been hijacked: a report to David Sackett Fake news See for comparison: Sugar Gliders, Flying Squirrels, and How Evolutionists Explain Away Uncooperative Data …contradictory evidence drives evolutionists to embrace irrational just-so stories. Natural selection cannot “adapt” anything. Natural selection kills off the bad designs. It cannot influence the random mutations that must, somehow, come up with such amazing designs. This is the hard reality, but in order to rationalize the…

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Hydrogen-Atom Transfer in DNA Base Pairs (4)

Historical perspective: Behold James Vaughn Kohl. Ecological adaptation occurs via the epigenetic effects of nutrients on alternative splicings of pre-mRNA which result in amino acid substitutions that differentiate all cell types of all individuals of all species. The control of the differences in cell types occurs via the metabolism of the nutrients to chemical signals that control the physiology of reproduction. These facts do not refute evolution; they simply refute the ridiculous theory of mutation-initiated natural selection that most people…

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Social experiences epigenetically effect gene networks

Networks of Genes Respond to Social Experiences October 13, 2013, from Searching for the Mind with Jon Lieff, M.D. Excerpt 1: “The gene networks of social experience are consistent through many animals.” My comment: Not just many animals; the gene networks of social experiences must be consistent in all animals that adaptively evolved. You cannot get from microbes to man with any consistent model of cause and effect until you realize that the molecular mechanisms that enable cause and effect…

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