Embryonic Stem Cells

Energy-dependent epigenetic translation to mRNA stability (5)

Energy-dependent epigenetic translation to mRNA stability (4) From Fertilization to Adult Sexual Behavior Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans…. See also: The Supraspliceosome – A Multi-Task Machine for Regulated Pre-mRNA Processing in the Cell Nucleus Abstract conclusion: …changes in these regulatory processing activities are associated with human disease and cancer. These findings emphasize the supraspliceosome as…

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Hecatombic evolution via oncocers and oncohistones

Mutation-driven evolution is being replaced by a theory of hecatombic evolution that links oncocers and oncohistones to increasing organismal complexity via autophosphorylation and autophagy or something else as yet to be invented in the context of the new ridiculous theory. See for comparison: Polycomb enables primitive endoderm lineage priming in embryonic stem cells Abstract excerpt: We show that altered transcription is the driver of these coordinated changes, known as lineage priming, in a process that exploits novel polycomb activities. What…

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Cancer: Evolution 2.0’s Blind Spot

See also: Hydrogen-atom transfer in DNA base pairs (5) Hydrogen-atom transfer in DNA base pairs (5) Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems Excerpt: …methylation of the carbon-5 position of cytosine, which results in differences in 5hmCs, may be the most commonly studied type of nutrient-dependent pheromone-controlled structural and functional eukaryotic modification that results from organizing base pair changes. Team uses internet network theory to decipher the first epigenetic communication network Excerpt: … 5hmC regulates changes in the compaction…

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Too many targets for theories

Random mutations are the substrates upon which directional natural selection acts.” —  Jay R. Feierman. Others have claimed that random mutations and natural selection somehow lead to the evolution of morphological phenotypes and behavioral phenotypes. They have not placed their claims into the context of what is known about ecological variation and ecological adaptations manifested as RNA-mediated sex differences in cell types of the human brain and all other cell type differences in all genera? Ecological variation is the raw…

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