energy as information

Energy-dependent alternative splicings 1996 – 2016

December 26, 2016
James Kohl
Adaptations, Alternative Splicings, Autophagy, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Highlights: 1) Alternative splicings of messenger RNA link the sun’s anti-entropic virucidal energy as information to DNA repair. 2) DNA repair links fixation of amino acid substitutions in supercoiled DNA to healthy longevity. 3) Supercoiled DNA protects all organized genomes from virus-driven energy theft and genomic entropy. 4) Genomic entropy is less likely to occur in the context of the physiology of reproduction and transgenerational epigenetic inheritance of ecologically adapted morphological and behavioral phenotypes. 5) Preventing virus-driven energy theft from…

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Energy-dependent oscillating gene networks organize life

December 26, 2016
James Kohl
Adaptations, Alternative Splicings, Autophagy, biophotonics, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Nascent, innate, intrinsic, and biofunctional are among the “weasel words” used by theorists who ignore the fact that all life-sustaining energy comes from the sun via hydrogen-atom transfer in DNA base pairs in solution. See how Jon Lieff continues to misrepresent that fact, by placing everything known about RNA-mediated cell type differentiation back into the context of evolution. Like all pseudoscientists, he starts with energy but fails to mention where the energy came from or where it goes when virus-driven…

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Re-inventing mutation-driven evolution (2)

December 20, 2016
James Kohl
Adaptations, Alternative Splicings, Autophagy, Diseases & Disorders, Ecology, RNA Directed
One Comment

See: Re-inventing mutation-driven evolution See also: Temperature regulates splicing efficiency of the cold-inducible RNA-binding protein gene Cirbp … we suspected that splicing efficiency, as defined by the fraction of pre-mRNA converted into mature mRNA, must have contributed to temperature-dependent Cirbp mRNA accumulation Splicing efficiency is energy-dependent in the context of temperature-dependent oscillations that link the sun’s anti-entropic virucidal energy to all biodiversity via Turing’s claims and my model. See also: The B/Z reaction, and the problem with peer review In…

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Bio-functional information

December 17, 2016
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Physics, RNA Directed, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations
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Peter Berean‘s attack on my model of energy as information led him to invent or re-introduce the term “Bio-Functional Information.” The comment from Greg Thurston (below) can be placed into the context of Schrodinger’s claims from “What is Life?” For instance, Schrodinger challenged de Vries definition of the term mutation with this entry: “Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more…

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Tasting light links energy from creation to adaptation

December 6, 2016
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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The C. elegans Taste Receptor Homolog LITE-1 Is a Photoreceptor “In Brief: A taste receptor homolog absorbs UV light and mediates avoidance behavior in C. elegans in response to light exposure.” Excerpt: Light sensation is critical for all phyla of life, ranging from bacteria to humans (Wang and Montell, 2007; Yau and Hardie, 2009). Organisms have evolved various types of photoreceptor proteins… Photoreceptors are G protein-coupled receptors (GPCRs). No experimental evidence of biologically-based cause and effect links the evolution of any…

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Metabolic Phenotyping Research

December 1, 2016
James Kohl
Adaptations, Diseases & Disorders, Ecology, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations
One Comment

Global Consortium to Conduct Metabolic Phenotyping Research Consortium members in six countries will use chromatography, mass spectrometry, and other technologies to conduct metabolic phenotyping research that examines the dynamic interactions between genes, environments, microbiomes, diets, and lifestyles, and their collective impact on disease. My Predictions. 1. They will link energy as information to healthy longevity. 2. They will report their findings as if they discovered new molecular mechanisms. 3. The mechanisms will link the anti-entropic virucidal energy of ultraviolet light…

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Light, behavior and autophagy, a gender-specific risk factor

November 22, 2016
James Kohl
Adaptations, Alternative Splicings, Autophagy, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation
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Structure of photosystem II and substrate binding at room temperature Excerpt: PS II, a membrane-bound multi-subunit pigment protein complex, couples the one-electron photochemistry at the reaction centre with the four-electron redox chemistry of water oxidation at the Mn4CaO5 cluster in the oxygen-evolving complex (OEC). New, detailed snapshots capture photosynthesis at room temperature The living machinery responsible for photosynthesis – while commonplace and essential to life on Earth – is still not fully understood. It is understood at every level of…

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Epigenetically effected energy-dependent fluorescence (2)

November 13, 2016
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated gene silencing, Variations
One Comment

We are just trying to understand your hypothesis. Peter Berean has wasted more of my time that nearly anyone else I have encountered, and he still claims my model is a hypothesis. On October 14, 2016 I asked: How can you or anyone else tell the difference between a secular humanist and an old earth creationist? For example, I can compare both sects to young earth creationists who have linked everything known about nutritional epigenetics to healthy longevity and everything…

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From Precis to Proof in 6000 years

November 5, 2016
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, RNA Directed
One Comment

Religious texts, such as The Holy Bible appear to be like a Precis of works from God. He seems to be explaining energy-dependent creation in the context of what is currently known to serious scientists about biophysically constrained RNA-mediated protein folding chemistry, healthy longevity and RNA-mediated biodiversity. God made it perfectly clear, in advance, that all miraculous biodiversity is energy-dependent. Energy as information is the theme that extends to the weekend resurrection of the bacterial flagellum in P. fluorscens. Biologically…

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Did evolution autophosphorylate your kinases? (2)

October 15, 2016
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
3 Comments

Hecatombic evolution Deep-Sea Viruses Destroy Archaea Excerpt: Given the enormous scale of deep-sea ecosystems, the results indicate that archaea-virus relationships could be a major contributor to global biogeochemical cycles. My comment:  I know that Anna Di Cosmo​ and John Hewitt​ are able to link virus-driven energy theft to all pathology in all living genera via the conserved molecular mechanisms they have already placed into their proper perspective on natural selection for energy-dependent codon optimality, which links the innate immune system…

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