energy-dependent

Hypothesis free pseudoscience vs facts (4)

See first Hypothesis free pseudoscience vs facts (3) See also: The terrorist inside my husband’s brain Conclusion: I know you have accomplished much already in the areas of research and discovery toward cures in brain disease. And I am sure at times the progress has felt painfully slow. Do not give up. Trust that a cascade of cures and discovery is imminent in all areas of brain disease and you will be a part of making that happen. If only…

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Hypothesis free pseudoscience vs facts (1)

Old Earth Creationist (OEC) Peter Berean, thinks I should change the claims in my model of energy-dependent biophysically constrained RNA-mediate protein folding chemistry. He does not like the fact that my model explains all pathology in the context of virus-driven energy theft. If viral latency is not nutrient energy-dependent and controlled by the physiology of reproduction in species from bacteria to humans, I will change my claims. If someone explains what is wrong with my model, I will try to…

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Base pairs, olfaction and RNA thermometers

RNA thermometer controls temperature-dependent virulence factor expression in Vibrio cholerae (2014) Excerpt: The stem-loop can be stabilized by strengthening the base pairing between the fourU element and SD sequence through the substitution of G-C base pairs, and this results in an elevated melting temperature (10). Conclusion: RNA thermometers represent a simple yet elegant mechanism for controlling temperature-dependent gene expression and may be more widespread among pathogenic bacteria that interact with mammalian hosts than is currently known. See also:  MicroRNA Stability…

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Chromatin: The structure of DNA (2)

A Genetically Encoded Probe for Live-Cell Imaging of H4K20 Monomethylation Excerpt (with my emphasis): Highlights •    A histone H4K20me1-specific live-cell probe, H4K20me1-mintbody, was developed. •    Dynamics and replication timing of Xi were visualized. •    Critical amino acids for the stability and/or folding of the mintbody were revealed. Reported as: Catching histones by the tail: A new probe to track histone modifications in living cells Excerpt: H4K20me1 is most likely associated with the tight packing of a redundant (inactivated) female X…

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Chromatin: The structure of DNA (3)

See:  Chromatin: The structure of DNA (2) Inherited parental methylation shifts over time, may have functional effects in the brain and other tissues Excerpt: …researchers have theorized that inherited methylation, also referred to as parental imprinting, largely remains stable throughout development, except during two important developmental milestones: after fertilization and during the creation of sperm and egg cells. Altered gene imprinting at other times has been associated with developmental disorders and cancer. My comment: Theorists have historically failed to learn…

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Chromatin: The structure of DNA

Update on Inflammation and Degenerative Brain Disease Excerpt: While mapping connections of neurons has become the holy grail of current neuroscience, it is clear that communication of neurons with many other types cells is, also, vitally important to every aspect of brain function. My comment: Understanding dementia was placed into the context of understanding how virus-driven energy theft alters the de novo creation of olfactory receptor genes and causes the loss of function that is linked to all pathology via…

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DNA repair via junk DNA (2)

See also: DNA repair via junk DNA (1) Recently Evolved Genes Identified From Drosophila yakuba and D. erecta Accessory Gland Expressed Sequence Tags (2006) Reported in Singer (2015) as: In 2006, Begun found some of the first evidence that genes could indeed pop into existence from noncoding DNA. Singer’s claim that genes automagically pop into existence is consistent with Masatoshi Nei’s conclusion in: Mutation-Driven Evolution …genomic conservation and constraint-breaking mutation is the ultimate source of all biological innovations and the…

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Light energy-induced base pair changes (2)

See: Light energy-induced base pair changes (1) To help others move forward via the concept of energy-dependent biophysically constrained RNA-mediated protein folding and what is known about how virus-driven energy theft is linked to all pathology, see also: Subatomic Particles, Part 1: Leptons Subatomic Particles, Part 2: Baryons, the Substance of the Cosmos Subatomic Particles, Part 3: Mesons If you are not ready to start from the de novo creation of the energy in a hydrogen atom, you may need…

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Light energy-induced base pair changes (1)

Semisynthetic organisms and synthetic biology Unintended Consequences of Expanding the Genetic Alphabet Conclusion: …phototoxicity results presented herein using a human skin cancer cell line are intended to create awareness to the scientific community of the potential unintended consequences of expanding the genetic alphabet with unnatural nucleosides like those used in this work. Reported as:  Unintended consequences of creating the world’s first semisynthetic organism Excerpt: …the artificial base pair makes living cells more susceptible to damage from low doses of sunlight and…

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Displays of ecological adaptation (2)

On 9/12/16 Philip Qua wrote I have not verified that all of his papers are peer review, but I do believe that some of them are. It is going to take some time and reading of James Kohl papers before I am even willing to venture whether they have merit or not. But on a first glance basis, what I think James is positing here is the causal-effect that drives evolution is more an energy based availability than a random…

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