energy-dependent

DNA repair via junk DNA (1)

Initiating DNA repair To communicate stress signals within cells, JNKs add phosphate groups to proteins, and the Rochester study found the amino acid residue on SIRT6 that is modified by JNK. They found an energy-dependent RNA-mediated amino acid substitution linked to the physiology of reproduction. It makes DNA repair and transgenerational epigentic inheritance of biologically-based cause and effect possible. The innate immune system, links RNA-mediated amino acid substitutions to supercoiled DNA and protection of organized genomes from virus-driven entropy. The…

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Linking RNA structure to function

A G-Rich Motif in the lncRNA Braveheart Interacts with a Zinc-Finger Transcription Factor to Specify the Cardiovascular Lineage was reported on September 8, 2016 as: Linking RNA structure and function Excerpt 1) Learning more about how lncRNAs control cell differentiation could offer a new approach to developing drugs for patients whose hearts have been damaged by cardiovascular disease, aging, or cancer. The insult to the intelligence of all serious scientists who have linked energy-dependent changes from angstroms to ecosystems in…

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Exosomes, Inflammatory Disease, Pathogenesis, Treatment

See also How did the innate immune system evolve? By now, all theorists should know what “innate” means.  It means the immune system did not evolve. It is an energy-dependent ecological adaptation in all living genera. It typically protects all organized genomes from virus-driven inflammation and disease. The Role of Exosomes in Inflammatory Disease: Pathogenesis and Treatment Thursday September 22, 2016 2:30 – 4:00 p.m. Eastern Time Exosomes encapsulate and transport a wide variety of molecules generated by their cell-of-origin,…

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The Aquatic Ape: New evidence?

The Waterside Ape BBC Radio 4 Publicity Sir David Attenborough considers whether new evidence will help a once widely ridiculed theory of human origins move towards to mainstream acceptance. In 1960, the eminent Oxford marine biologist Sir Alister Hardy proposed a revolutionary idea: that our human ancestors had not started their existence on the wide savannahs of Africa, but had become accustomed to living alongside water – swimming and diving in the shallows, collecting the abundant food, and learning to…

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Energy-dependent cellular communication

Communication shapes sensory response in multicellular networks Significance Cells routinely sense and respond to their environment, and they also communicate with each other. Exactly how communication impacts sensing remains poorly understood. We study a population of fibroblast cells that responds to a chemical stimulus (ATP) and communicates by molecule exchange. Combining experiments and mathematical modeling, we find that cells exhibit calcium oscillations in response to not only the ATP stimulus but also, increased cell–cell communication. Our results show that, when…

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Lawless evolution: No physics

New leader of NIH’s research watchdog faces staff revolt Partin may be looking to NSF for ideas about how to handle charges of plagiarism. Although 81% of NSF’s research misconduct findings involve plagiarism, ORI has left most plagiarism allegations to institutions to handle. Plagiarism was so widespread more than 20 years ago that the co-author of my book said to ignore it. The continuation of the problem for two decades has left pseudoscientists in charge and put the claims serious…

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Antithetical conclusions (7)

Streamlining the E.coli Genetic Code Once the E. coli genome is pared down to 57 codons, the seven blank codons can be reintegrated and used to introduce nonstandard amino acids, the researchers have proposed; this would open the door to creating a wider range of proteins for industrial applications. A recoded genome also imparts resistance to viral infection and can be used for biocontainment: the DNA incorporated from wild-type E. coli or viruses can’t be used to build proteins successfully…

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Antithetical conclusions (5)

Something is antithetical when it is in complete and utter opposition to the character of something. For example, see: Small population size? It doesn’t have to mean that species can’t adapt to environmental change. A new study shows that small populations of species can still adapt and respond to natural selection. Natural selection for energy-dependent codon usage in the context of the physiology of reproduction is the only way known to serious scientists for a species to ecologically adapt. Theorists…

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Non-random pheromone-controlled cell type differentiation

Experience-Dependent Plasticity Drives Individual Differences in Pheromone-Sensing Neurons Aug 17, 2016   •Individual differences in cell types are not random •Sex differences in pheromone-sensing neurons are controlled by experience •Changes in specific cell types are governed via “use it and lose it” plasticity •Targeting plasticity to specific cell types changes animal behavior This was reported as: Long-term exposure to female scents changes courtship behavior in male mice The senior author co-authored Chromatin remodeling inactivates activity genes and regulates neural coding…

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RNAi: From magic bullet to billion dollar baby

UW-Madison technology enlisted in battle against hepatitis B DNA operates through RNA, and when RNA interference was discovered in 1998, it seemed like a magic bullet that could fight disease by specifically shutting down problematic genes. Before RNA interference was discovered pre-mRNAs were already linked to cell type differentiation in species from microbes to mammals. From Fertilization to Adult Sexual Behavior (1996) Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to…

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