energy-dependent

Energy-dependent sensory maps (1996-2016)

Developmental broadening of inhibitory sensory maps My summary: They help to detail how olfactory input causes the energy-dependent de novo creation of sensory maps, which are representations of the external world. The experience-dependent representations link chemotaxis and phototaxis to biophysically constrained behavior. The representations are systematically organized in brain structures throughout development. Simply put, the maps are links from the epigenetic landscape to the physical landscape of supercoiled DNA in organized genomes. By investigating how ongoing neurogenesis in the mouse…

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Sudden death indel polymorphism

An insertion/deletion polymorphism within 3’UTR of RYR2 modulates sudden unexplained death risk in Chinese populations. …different alleles of rs10692285 could alter the local structure of RYR2 mRNA and microRNA (miRNA) binding. See for comparison: Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant The differences between the 370A knockin mouse phenotypes and those of loss- and gain-of-function models emphasize the advantage of a more accurate mouse model. In this study an adaptive variant links the mouse…

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Theories vs facts about polycombic adaptation

See: Demoncrats fight polycombic ecological adaptation Exosomes as miRNA Carriers: Formation–Function–Future Important aspects will be highlighted as a take-home message (THM) at the end of each paragraph. THM: Extracellular vesicles transport miRNA in a paracrine and endocrine manner. Questions regarding the cellular options of producing either microvesicles or exosomes and their difference in miRNA composition and number are still unknown. In my 2014 invited review, the four F’s, Formation–Function–Future and Copulation were included in details about how the nutrient energy-dependent…

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Tasting light links energy from creation to adaptation

The C. elegans Taste Receptor Homolog LITE-1 Is a Photoreceptor “In Brief: A taste receptor homolog absorbs UV light and mediates avoidance behavior in C. elegans in response to light exposure.” Excerpt: Light sensation is critical for all phyla of life, ranging from bacteria to humans (Wang and Montell, 2007; Yau and Hardie, 2009). Organisms have evolved various types of photoreceptor proteins… Photoreceptors are G protein-coupled receptors (GPCRs). No experimental evidence of biologically-based cause and effect links the evolution of any…

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Politicized science: The demise of RNA-mediated.com?

A post-Presidential election change indicates that politicized science in the USA may be the cause of the steady decline in the number of pages read on this domain. The decline is paired with an increased bounce rate each time I post anything that pits the science of creation against the pseudoscientific nonsense of neo-Darwinian theories. If this domain were used in the context of a social science experiment, the statistics would show that ridiculous theories have left the USA relatively…

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Combating evolution: Battlefield medicine vs politicized science

A steady decline in the number of pages read on this domain is paired with an increased bounce rate each time I post anything that pits the science of creation against the pseudoscientific nonsense of neo-Darwinian theories. If this domain were used in the context of a social science experiment, the statistics would show how theories have left the USA relatively defenseless against the threat of gene-editing technology, which has has been advanced in countries where students are not taught…

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The futility of The Battlefield FB group

Apparently, Paul Hartley blocked me from further discussion of his OP about dinosaurs and gladiators before I could ask if he thought “The Battlefield” is a “false flag” group. Does anyone else think that?   If so, do you think it can survive publication of experimental evidence that links responsive supramolecular systems to stepwise changes in the assembly of metal complexes via induction of a light-driven rotary motor scaffold akin to the bacterial flagellum of P. fluorescens? See: Dynamic control…

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Energy-dependent purifying selection / autophagy (3)

See also: Energy-dependent purifying selection / autophagy (2) But see: Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters Re: “…the interactomes of 31,253 annotated promoters in 17 human primary blood cell types.” Excerpt: Here, we link thousands of GWAS SNPs to their putative target genes and prioritize more than 2,500 potential disease-associated genes, three-quarters of which were not previously implicated. Reported as: Researchers identify missing links that connect human DNA variation with disease My comment:…

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Energy-dependent purifying selection / autophagy (6)

See: Energy-dependent purifying selection / autophagy (5) Simply put all aspects of biophysically constrained energy-dependent cell type differentiation must first be linked from the physiology of reproduction to ecological adaptations, or they must be linked from energy theft to the evolution of pathology. See for contrast and comparsion: Finding your diagnosis in the brave new world of genetics-based medicine by John Hewitt Excerpts: Typically all they have is a stack of diffuse paper reports and xeroxed publications from the primary…

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Base pairs, amino acids and phenotypes

Holliday junction trap shows how cells use recombination and a junction-guardian role of RecQ helicase DNA repair by homologous recombination (HR) underpins cell survival and fuels genome instability, cancer, and evolution. Autophagy is the established link from energy-dependent changes in base pairs and RNA-mediated amino acid substitutions to DNA repair in the context of polycombic ecological adaptations that prevent the hecatombic evolution of virus-driven pathology. Inventing new detailed models of DNA repair serves only to confuse those who have already…

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