entropic elasticity

microRNAs, glycosylation, and genomes

Summary: Given what is currently known about RNA-mediated cell type differentiation in all genera, it may be impossible for theorists to link mutations to evolution via glycosylation. miRNA proxy approach reveals hidden functions of glycosylation Abstract excerpt: Glycosylation, the most abundant posttranslational modification, holds an unprecedented capacity for altering biological function. Journal article excerpt: …glycans microRNAs, glycosylation, and genomes

Missing a fact: microRNAs are genomic biomarkers

Summary: The nutrient-dependent microRNA/messenger RNA balance links virus-induced entropic elasticity and the anti-entropic epigenetic effects of nutrient-dependent protein biosynthesis and degradation to everything that is currently known about RNA-directed DNA methylation and RNA-mediated amino acid substitutions. The substitutions differentiate the cell types of all genera. That fact is not being reported in most of the Missing a fact: microRNAs are genomic biomarkers

MicroRNAs and the exposome (2)

Odd histone helps suppress jumping genes in stem cells, study says Excerpt 1) Chemical modifications to these histones can change the expression of genes, making them more available for expression or silencing them by compacting the DNA-protein complex. Oddball H3.3 varies from its regular counterpart H3 by only few amino acids. Excerpt 2) The research MicroRNAs and the exposome (2)

Finding odor and taste receptors everywhere

Bitter taste receptor agonists elicit G-protein-dependent negative inotropy in the murine heart was published in October 2014 and reported in May 2015 as: Researchers find bitter taste receptors on human hearts Excerpt: “While the underlying physiology behind this phenomenon remains unclear, this is now a major area of ongoing investigation.” For a historical perspective on Finding odor and taste receptors everywhere

RNA-mediated silencing of a chromosome

The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3was reported as: How an RNA gene silences a whole chromosome Summary: “Researchers have discovered how an abundant class of RNA genes, called lncRNAs can regulate key genes. By studying an important lncRNA, called Xist, the scientists identified how this RNA gathers a group RNA-mediated silencing of a chromosome

Origin of life and cancer (1,2,3)

1) On the Origins of Life The physics of the light-induced de novo creation of the amino acids was placed into the context of  ‘cyanosulfidic’ protometabolic systems chemistry. The systems chemistry links substitution of achiral glycine in the gonadotropin releasing hormone (GnRH) decapeptide to the biophysically constrained nutrient dependent RNA-mediated chemistry of protein folding in Origin of life and cancer (1,2,3)

A genetic variant refutes neo-Darwinism

Summary: They link a single nucleotide polymorphism (SNP) to a genetic variant that decreases viability of an embryo, without linking a nutrient-dependent RNA-mediated amino acid substitution to pheromone-controlled cell type differentiation that begins in the embryo and continues throughout the life history transitions of invertebrates and vertebrates. A Benefit of Failed Pregnancy? This genome-wide association A genetic variant refutes neo-Darwinism

Life: conserved ion and amino acid transporters

The vital question: Why is life the way it is? Excerpt: “…any sufficiently advanced chemiosmotic geochemistry is indistinguishable from life.” My comment: If the differences between viruses and cellular life are removed, the link from viral microRNAs to the anti-entropic epigenetic effects of nutrient-dependent microRNAs limits explanations of how the nutrient-dependent microRNA/messenger RNA balance leads Life: conserved ion and amino acid transporters