environment

Enzyme-constrained interethnic biodiversity (4)

No, they don’t. See: Why Is This Bacterium Hiding in Human Tumors? Whether Fusobacterium nucleatum causes colon tumors is unknown. But a new study hints that it may be “an integral part of the cancer.” Serious scientists have linked bacteriophages to all virus-driven pathology. Cancer is a virus-driven pathology. That’s the truth! In  the New York Times article by Gina Kolata she wrote: “The whole idea of bacteria in tumors is fascinating and unexpected,” said Dr. Bert Vogelstein, a colon…

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For God and Country

Energy-dependent structure and function: Until death (3)

Energy-dependent structure and function: Until death (2) The COMT Val158Met polymorphism supposedly is not found in species other than humans See: Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles This is also the first study establishing the COMT*L allele as the derived allele unique to humans. Other organisms do not commit suicide. That suggests the human specific COMT Val158Met substitution may be important to those who know very little about suicide prevention. For instance, see: The catechol-o-methyltransferase Val158Met polymorphism…

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For God and Country

Energy-dependent structure and function: Until death (2)

Energy-dependent structure and function: Until death (1) Terry Crews details alleged sexual assault by ‘high level’ Hollywood exec “This whole thing with Harvey Weinstein is giving me PTSD. Why? Because this kind of thing happened to ME…” Crews tweeted Tuesday. This claim helps to link the celebrity status of Hollywood victims like Robin Williams to the suicide rate in veterans who have returned from military service overseas with viruses. The viruses clearly link energy-dependent changes in the microRNA/messenger RNA balance…

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For God and Country

Energy-dependent structure and function: Until death (1)

The structure-energy landscape of NMDA receptor gating …using single-molecule Forster resonance energy transfer (smFRET), we map the energy landscape of the first transmembrane segment of the Rattus norvegicus NMDA receptor under resting and various liganded conditions. These results show kinetically and structurally distinct changes associated with apo, agonist-bound, and inhibited receptors linked by a linear mechanism of gating at this site. Furthermore, the smFRET data suggest that allosteric inhibition by zinc occurs by an uncoupling of the agonist-induced changes at…

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Autophagy is the antiphage defense strategy

The “Antiphage Defense Strategy” in Vibrio anguillarum is called autophagy by many serious scientists. It links nutrient energy-dependent pheromone-controlled quorum sensing to viral latency, healthy longevity, symbiosis, reproduction, and biodiversity from microbial species to humans. For an evolutionary approach to energy-dependent autophagy that fails to address any aspect of how virus-driven energy theft causes all pathology see: (12/7/16) Part I: Living together: The symbiosis of host-microbial interactions (12/7/16) See also: 12/7/16 ….McFall-Ngai tells the story of a symbiosis between the…

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Models of scientific literacy

Scientific Literacy Redefined Researchers could become better at engaging in public discourse by more fully considering the social and cultural contexts of their work. By Cynthia Brandenburg | February 1, 2016 Excerpt: …any truly productive conversation about why their fears are scientifically unfounded must be predicated upon an understanding of what caused those fears in the first place. My comment: “A Fear of Pheromones” led many researchers to ignore the fact that metabolic networks must be linked to genetic networks…

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MicroRNAs and invasive phenotypes

Variability helps mammals to become invasive Excerpt: The authors argue that species exposed to a novel environment will have higher chances of surviving if they are variable and can therefore adapt to many different environmental conditions. My comment: Nutrient-dependent pheromone-controlled morphological and behavioral phenotypes are linked by microRNAs to adaptive radiation and to all of extant biodiversity. For an example of the role of RNA-mediated events that link metabolic networks to genetic networks, see: “Large Numbers of Novel miRNAs Originate…

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Quantum correlations/pseudoscience

A quantum advantage for inferring causal structure Preprint excerpt: “The causal inference schemes described here promise extensive applications in experiments exhibiting quantum eff ects. For instance, they can provide a test of whether the dynamics of a given open quantum system is Markovian or not [17{24]. This is because in a non-Markovian evolution, the environment acts as a common cause between the dynamical system at one time and the same system at a later time. Our inference schemes may also help…

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No excuses: Creation and the meaning of organismal complexity

E.O. Wilson On ‘The Meaning Of Human Existence’ Excerpt: “We’re one species — glorious though we are — we are just one species out of an estimated eight million,” Wilson said. “At the present time, we only know almost exactly two million species — enough to give them a scientific name. Six million species are out there, maintaining the planet for us as an autonomous ecosystem and stabilization system. Book Excerpt: ‘The Meaning of Human Existence’ “Six million species are…

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