epigenetic changes

Inventing “Transcriptome Trajectory Turning Points”

Summary: They invented the term “Transcriptome Trajectory Turning Points” to prevent others from learning that virus-driven energy theft is the cause of all pathology. Scientists discover genetic timetable of brain’s aging process The biggest reorganisation of genes occurs during young adulthood, peaking around age 26, the team found. These changes affected the same genes that are associated with schizophrenia. The team says this could explain why people with schizophrenia do not show symptoms until young adulthood, even though the genetic…

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What energy source do proteins prefer?

Quantized energy as information is the anti-entropic virucidal source of healthy longevity. All pathology is caused by virus-driven energy theft. Impact of cytosine methylation on DNA binding specificities of human transcription factors …many developmentally important proteins display preference for mCpG-containing sequences.   How do proteins display a preference for anything except food and codon optimality? Natural selection for quantized food energy-dependent codon optimality links the structure and function of supercoiled DNA to protection from virus-driven energy theft. That fact was…

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Despicable fools?

Metamaterial Offers Simpler Route to Slow Light Excerpt: Light is generally accepted to travel at a constant speed, but its group velocity can be slowed by passing through refractive materials. Compared to its top speed in a vacuum, light travels slightly slower in air and slightly slower still in water. These changes in speed are fairly insignificant, however. My comment: I doubt that any member of the RNA society thinks that the changes that link the de novo creation of…

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Stress-perturbed mitochondrial dysfunction

Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory, and transcriptional responses to acute psychological stress Excerpt: To visualize the stress-reactive profiles across genotypes, a heat map with hierarchical clustering of the mean relative difference “stress–resting” was generated, demonstrating that each mitochondrial defect induced a different amino acid response signature (Fig. 4F). In particular, the stress-reactive amino acid profile was most distinct in mice with the respiratory chain complex I ND6 defect. To determine which class of amino acids was most discriminatory between…

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Is the best Chinese research from China?

8 and great: the best Chinese research of 2015 in Genome Biology Excerpt 1) They found that the relationship between mRNA and protein levels is increasingly unlinked during aging. This occurrence is likely caused by modifications to the mRNA that alter stability, or prevent translation into proteins. Many of the genes that were predicted to be targeted for these modifications are known to be involved in lifespan extension, mitochondrial function, and Alzheimer’s disease. My comment: The modifications to the mRNA…

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