Epigenetic

The tipping point (revisited): 73,000 publications

May 16, 2018
James Kohl
Adaptations, Autophagy, Cytosis, Diseases & Disorders, Ecology
2 Comments

Summary: The Bill and Melinda Gates Foundation appears to be funding misrepresentations of what serious scientists know about biophysically constrained viral latency, as if no one knew that the effect of virus-driven energy theft in a computer processing unit (CPU) is the same as the effect of bacteriophages on the human brain. The countdown that led scientific creationists in South Korea to force the denuclearization of North Korea started 2 years ago (today). 5, 4, 3, 2, 1 Predicting microRNA-disease…

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The eternal significance of microRNAs (8)

May 15, 2018
James Kohl
Adaptations, Diseases & Disorders, Ecology, microRNA editing, RNA Directed, RNA interference, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity
No Comments

Use of definitions in attempts to explain any aspect of species-specific biophysically constrained cell type differentiation and aging has been replaced by the use of model systems of biological processes.  Biological processes can be compared to so-called “evolutionary processes” to show that only biological processes need to be considered in the context of Darwin’s “conditions of life” or answers to the the question  What is Life? Schrödinger (1944). K. L. Mettinger et al. (eds.), Exosomes, Stem Cells and MicroRNA, Advances…

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Physicists: Desperate Acts (revisited)

February 6, 2017
James Kohl
Adaptations, Alternative Splicings, Autophagy, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA-directed DNA methylation, Variations
One Comment

Physicists: Desperate Acts Light-induced endogenous RNA interference in bioluminescent microbes links Schrodinger’s claims in “What is LIfe?” (1944) from a light-to-chemical pathway of information exchange in all living genera via amino acid substitutions in supercoiled DNA. All subsequent works on the evolutionary synthesis failed to link  the anti-entropic virucidal energy of sunlight to Darwin’s “conditions of life” from the claims of Schrodinger (1944) or the claims of any other serious scientist. Indeed, in the case of higher animals we know…

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Expunging the distinguished public

December 12, 2016
James Kohl
Adaptations, Autophagy, Ecology, Light Energy, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA-directed DNA methylation, RNA–Mediated Epigenetic Heredity, Variations
No Comments

Royal Society Expunges Public From Evo Record Many of the attendee-participants were, in fact, more distinguished than many of the actual speakers. So the audience came to be heard as well as to listen. But the official recording (now posted) has been wiped clean of public comment — the most robust part of the meeting — and what we are left with, with few exceptions, is a series of academic lectures and old science. Thanks for continuing to make the…

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Energy-dependent de novo creation and neurogenesis

December 8, 2016
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
One Comment

See also: Tasting light links energy from creation to adaptation Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning reported as: When neurons are ‘born’ impacts olfactory behavior in mice My summary: The de novo creation of different cell types is placed into the context of their energy-dependent birth and the transgenerational epigenetic inheritance of molecular mechanisms that link virus-driven energy theft to all pathology via olfaction, food odors, and human pheromones. See for comparison: Metabolism and neurogenesis …it…

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Hydrogen-atom energy in DNA base pairs

September 19, 2016
James Kohl
Adaptations, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Neuronal Plasticity, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, Variations
One Comment

See also: Consciousness is simply food rearranged Role of Double Hydrogen Atom Transfer Reactions in Atmospheric Chemistry Abstract excerpt:  Hydrogen atom transfer (HAT) reactions are ubiquitous and play a crucial role in chemistries occurring in the atmosphere, biology, and industry. My comment: The link from physics to chemistry and the conserved molecular mechanisms of biologically-based RNA-mediated cell type differentiation has been the focus my works for more than 20 years, even before I knew what I would need to explain…

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Energy-dependent cellular communication

August 29, 2016
James Kohl
RNA Directed
No Comments

Communication shapes sensory response in multicellular networks Significance Cells routinely sense and respond to their environment, and they also communicate with each other. Exactly how communication impacts sensing remains poorly understood. We study a population of fibroblast cells that responds to a chemical stimulus (ATP) and communicates by molecule exchange. Combining experiments and mathematical modeling, we find that cells exhibit calcium oscillations in response to not only the ATP stimulus but also, increased cell–cell communication. Our results show that, when…

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Anthetical conclusions

August 18, 2016
James Kohl
RNA Directed
No Comments

Something is antithetical when it is in complete and utter opposition to the character of something. Analysis of protein-coding genetic variation in 60,706 humans reported as: Largest collection of human exome sequence data yields unprecedented tool for diagnosing rare disease …variation that was expected, but not found, in the data offered new insight. Some genes were found to have less than the expected number of missense mutations, which change the protein sequence, or “loss-of-function” mutations, which obliterate protein function. With…

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MicroRNAs and sexual orientation

June 26, 2016
James Kohl
RNA Directed
No Comments

A neural circuit encoding sexual preference in humans Excerpt: We anticipate the identification of a core neural circuit for sexual preferences to be a starting point for further sophisticated investigations into the neural principles of sexual behavior and particularly of its aberrations. My comment: They link sexual orientation in yeasts to humans but fail to recognize the fact that it is nutrient energy-dependent and pheromone-controlled by RNA methylation, the innate immune system, and supercoiled DNA. 20 years after we published…

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RNA methylation

June 15, 2016
James Kohl
Adaptations, Ecology, Model Organisms, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
No Comments

This is a brief history of events that led me to found the domain RNA-mediated.com with some follow-up on the latest news about cell type differentiation In 2012, I attended this minisymposium 006.Transcribing Memories: New Mechanisms of Activity-Regulated Gene Expression and Their Roles in Experience-Dependent Plasticity. Description: Activity-regulated gene transcription is essential for orchestrating the gene expression programs that drive experience-dependent plasticity of neural circuits. Recent studies have not only vastly expanded our understanding of the mechanisms that mediate activity-regulated…

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