Epigenetic

Drunks and Monkeys: Pseudoscientific nonsense

Drunks and Monkeys Understanding our primate ancestors’ relationship with alcohol can inform its use by modern humans. By Robert Dudley | June 1, 2014 Excerpt: “…if the right kinds of bacteria are also present, fermentation will stabilize certain foodstuffs (think cheese, yogurt, sauerkraut, and kimchi, for example).” My comment:  Epigenetic changes induced by ethanol in astrocytes link histone acetylation, DNA methylation, and non-coding microRNAs in the developing and adult brain from frugivory to the nutrient-dependent de novo creation of olfactory receptor genes in bats. The…

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Soft atheism: a case for Creation

The Case for ‘Soft Atheism’ By GARY GUTTING   Excerpt: “…much as I admire Dawkins’s work in evolutionary biology and in enhancing the public understanding of science…” My comment: The case against evolution. Quantitative analysis of RNA-protein interactions on a massively parallel array reveals biophysical and evolutionary landscapes Biophysical constraints that enable the intermolecular tethering of RNA to DNA also link the epigenetic landscape to the physical landscape of DNA via the conserved molecular mechanisms of RNA-mediated events in species from…

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Nutrition, pheromones and cancer (2)

See: Nutrition, pheromones and cancer Despite the inaccurate reporting of exeperimental evidence, the link from the nutrient-dependent pheromone-controlled microRNA / messenger RNA balance is becoming clearer. Unfortunately, due to the inaccurate reporting, others may need to take the free course: Epigenetic Control of Gene Expression, before they can begin to understand the scientific progress in cancer research, which is occurring because some researchers have dispensed with the pseudoscientific nonsense of evolutionary theory. See for example: Biogenesis of intronic miRNAs located…

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MiRNAs methylation and ecological adaptation sans mutations

MiRNAs methylation and ecological adaptation sans mutations  “Our 2003 Molecular and Cellular Biology paper …opened the mechanistic ‘black box’ of the developmental origins of adult disease susceptibility, and firmly placed the word, epigenetics, in the vernacular of this research field.”  — Randy Jirtle (2009) Our 1996 Hormones and Behavior paper included a section on molecular epigenetics with evidence that attested to the involvement of epigenetics in the context of olfactory/pheromonal input and the developmental origins of hormone-organized and hormone-activated adult sexual behavior.…

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96 fixed amino acid substitutions, not 96 genes

19 December, 2013 – 09:31 april holloway Entire Neanderthal genome finally mapped – with amazing results Excerpt (with my emphasis): “Only 96 genes responsible for making proteins in cells are different between modern humans and Neanderthals. Intriguingly, some of the gene differences involve ones involved in both immune responses and the development of brain cells in people.” “Somewhere within these 96 genes may lay the answer to why Neanderthals and Denisovans became extinct.” Journal article: The complete genome sequence of a Neanderthal from the Altai Mountains Excerpt (with…

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Social experiences epigenetically effect gene networks

Networks of Genes Respond to Social Experiences October 13, 2013, from Searching for the Mind with Jon Lieff, M.D. Excerpt 1: “The gene networks of social experience are consistent through many animals.” My comment: Not just many animals; the gene networks of social experiences must be consistent in all animals that adaptively evolved. You cannot get from microbes to man with any consistent model of cause and effect until you realize that the molecular mechanisms that enable cause and effect…

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Pheromone-controlled thermodynamics and cancer

“If you learnt evolutionary biology and genetics a decade or more ago you need to be aware that those debates have moved on very considerably, as has the experimental and field work on which they are based.” — Denis Noble Can thermodynamics help us better understand human cancers? Excerpt: “In a new study, UCLA researchers analyzed the gene-expression profiles of more than 2,000 patients and were able to identify cancer-specific gene signatures for breast, lung, prostate and ovarian cancers. The…

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Your comment is awaiting moderation

After I posted 5 of the 14 comments to the National Geographic site during discussion of Mercenary Ants Protect Farmers With Chemical Weapons by Ed Yong, I got the message: “Your comment is awaiting “moderation” Typically, that means I will not be allowed to continue participation in the discussion I started, which is why I am blog-posting my comment here. Perhaps I have been too harsh in my responses to people who keep politely telling me I am WRONG. Perhaps,…

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Functional coding variants are not mutations

Rare coding variants of the adenosine A3 receptor are increased in autism: on the trail of the serotonin transporter regulome “Conclusions: Our results validate the hypothesis that the SERT regulatory network harbors rare, functional variants that impact SERT activity and regulation in ASD, and encourages further investigation of this network as a site for additional functional variation that may impact ASD risk.” My comment: This open access article mentions mutations, but the title and conclusion correctly infer that coding “variants”…

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Mirror neurons and microRNA: theory vs biological facts

Mirror neurons through the lens of epigenetics to be published in Trends in Cognitive Sciences Volume 17, Issue 9, September 2013, Pages 450–457. epub on 14 August 2013 Abstract excerpt: … we propose a new evolutionary developmental biology (evo-devo) perspective, which predicts that environmental differences early in development should produce variations in mirror neuron response patterns, tuning them to the social environment. See Figure 1: Excerpt: “…the early social experience produces modifications in gene expression through epigenetic marks, such as…

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