Epigenetic

Pheromones and cancer

Transcription Factor-MicroRNA-Target Gene Networks Associated with Ovarian Cancer Survival and Recurrence Excerpt: “MicroRNAs (miRNAs) are small, non-coding RNA molecules that bind to complementary sequences on target mRNA transcripts, and thus, regulate gene expression at the post-transcription stage. Transcription factors (TFs) are a different type of regulator. These proteins bind to specific DNA sequences in the promoter region, promoting or repressing transcription into mRNA, and thus, regulate genes at a pre-transcription stage [4]. TFs and miRNAs can regulate each other and…

Read More

A thought experiment

I may be confused about proximate and ultimate cause, especially if the role of transgenerational epigenetic inheritance is not central to the extended evolutionary synthesis. Isn’t transgenerational epigenetic inheritance the problem that led Dickins and Rahman to suggest a thought experiment; one where epigenetic mechanisms introduce shifts in learning bias for certain associations as would endocrine functioning? If so, my model (Kohl, 2012), which combines the epigenetic effects of nutrient chemicals and pheromones with biased endocrine functioning and adaptive evolution,…

Read More