Epigenetic

Virus-driven origin of life

On the Origins of Life A new experimental system demonstrates that precursors of ribonucleotides, amino acids, and lipids may have simultaneously arisen from the same prebiotic chemistry. By Jef Akst | March 17, 2015 “This is a very important paper,” Jack Szostak, a molecular biologist and origin-of-life researcher… See also: Luis P. Villarreal: We Need a Nonlinear Language for Life Nobelist Jack Szostak has told me this about autocatalytic sets: the people who came up with the original idea, like…

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RNA-directed gene choice

March 2015: ChemoSense; see Timothy S. McClintock: “Odorant Receptor Gene Choice” He concludes: “The epigenetic control of OR gene expression through repression and de-repression is a remarkable story, and as a fundamental mechanism intimately associated with the random differentiation of a neural progenitor cell into multiple neuronal subtypes, one wonders whether it might be a framework for understanding other instances of differentiation of neural subtypes (Lyons and Lomvardas, 2014).” My comment: The epigenetic control of OR gene expression is RNA-directed…

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RNA directed DNA methylation and cell types

Cell type differentiation is included in all topics in biology, which is why it is important to understand what is currently known about top-down causation in the context of physics and chemistry. Taken together, physics, chemistry, and the conserved molecular mechanisms of biology link Drosophila to Octopuses and all other species on this planet via RNA-directed DNA methylation and RNA-mediated amino acid substitutions that differentiate cell types. See for examples: Let there be anti-entropic light (1) An antagonist led me…

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Reverse phosphorylation

See for review: Let there be anti-entropic light (1)   Squid are hyper-editors when it comes to RNA This is a great summary of what is currently known about anti-entropic light and nutrient-dependent RNA-mediated pheromone-controlled cell type differentiation. Excerpt: “During RNA editing, specific enzymes alter nucleotides in mRNA transcripts so that the resulting protein differs in amino acid sequence from what was encoded by the original DNA. Such RNA editing is a means to generate greater protein diversity…” The RNA-editing…

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Nutritional epigenetics, exercise, and immune system integrity

Anti-inflammatory mechanism of dieting and fasting revealed Summary: Researchers have found that a compound produced by the body when dieting or fasting can block a part of the immune system involved in several inflammatory disorders such as type 2 diabetes, atherosclerosis, and Alzheimer’s disease. My comment: For the obvious link from nutrition and exercise to reproduction and RNA-mediated transgenerational epigenetic effects on the morphological and behavioral phenotypes of all species that must “move” to find food or to find mates…

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The biologically-based origin of the mammalian placenta (2)

See also: The biologically-based origin of the mammalian placenta I’ll preface this follow-up on the origins of the mammalian placenta with comments that attest to foolishness of theoretical physicists who try to link Big Bang cosmology to neo-Darwinian theories about mutations and evolution. RPF Interviews Dr. Alexander Unzicker Excerpt 1)  “It annoys me too much to see another generation of physicists deterred by the dumb messy patchwork called the standard model of particle physics, that hides the basic problems physics…

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ISHE's human ethology group

On January 7, 2015, the moderator of the ISHE’s human ethology yahoo group posted this notice to the group. RNA-mediated epigenetic regulation of gene expression D Holoch, D Moazed – Nature Reviews Genetics, 2015 Diverse classes of RNA, ranging from small to long non-coding RNAs, have emerged as key regulators of gene expression, genome stability and defence against foreign genetic elements. Small RNAs modify chromatin structure and silence transcription by guiding … Until January 7, 2015, research has typically been portrayed in the context of…

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The future of physics predicts no future for evolutionary theory

The ever-smaller future of physics ‘Theory of everything’ captures Weinberg’s imagination in Lee Historical Lecture Excerpt: “…there are hints that the answers to fundamental questions will reveal themselves at around a million billionths — between 10­-17 and 10-19 — of the radius of the typical atomic nucleus. My comment: Evolutionary theorists may not recognize the problem that this presents. By accepting de Vries definition of “mutation” and rejecting experimental evidence, which links the epigenetic landscape to the physical landscape of…

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Model organisms: the birds and the bees

Bird Genomes Abound Scientists complete the largest-ever comparative genomic study of birds. By Ruth Williams | December 11, 2014 Excerpt: “Birds are model organisms for a number of human behaviors and conditions—For example, Jarvis compares vocal learning in birds and humans—so determining the genetic basis of such traits requires genetic history.” My comment: Honeybees are model organisms for “…human immunity, disease resistance, allergic reaction, circadian rhythms, antibiotic resistance, the development of the brain and behavior, mental health, longevity, diseases of…

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Glycine and GnRH: Am I being pedantic?

Posted to the FB page on 12/3/14 at Skeptics; Atheists; Realists; Agnostics; Humanists Stephen Hawking and Brian Cox take part in Monty Python sketch – video Excerpt: “I think you are being pedantic.” My comment: Some people may think I am being pedantic. My focus is not on physics; it is on the role of GnRH in cell type differentiation. My focus now extends from what is known about quantum physics, quantum smell, chirality, quantum biology, and quantum consciousness. What is known about chirality…

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