epistasis

Predicting who wins the 2017 Nobel Prizes (2)

Lethal virus kills 5 billion people?

Summary: Endogenous RNA interference is the energy-dependent epigenetic link from the physiology of pheromone-controlled reproduction to biophysically constrained viral latency. The stress-linked virus-driven degradation of messenger RNA has been linked to all pathology. Three Americans win Nobel medicine prize for body rhythm work [But they failed to link Americanism to Creationism] I predicted that Wen Predicting who wins the 2017 Nobel Prizes (2)

Energy-dependent physical and biophysical constraints (1)

Summary: The hitchhiking, the epistasis, and the dynamics of adapting populations are energy-dependent and biophysically constrained in the context of RNA-mediated protein folding chemistry. The virus-driven degradation of messenger RNA links mutations to all pathology in all living genera. An upper limit on the functional fraction of the human genome For the human population to Energy-dependent physical and biophysical constraints (1)

Energy-dependent microRNA biogenesis

Published May 3, 2017 Genetic variation and RNA structure regulate microRNA biogenesis …primary sequence determinants and RNA structure are key regulators of miRNA biogenesis. Genetic variation aka primary sequence determinants are energy-dependent and RNA-mediated. Energy-dependent RNA methylation is an experience-dependent link from natural selection for energy-dependent codon optimality. Natural selection for energy-dependent codon optimality links Energy-dependent microRNA biogenesis

Tasting light links energy from creation to adaptation

The C. elegans Taste Receptor Homolog LITE-1 Is a Photoreceptor “In Brief: A taste receptor homolog absorbs UV light and mediates avoidance behavior in C. elegans in response to light exposure.” Excerpt: Light sensation is critical for all phyla of life, ranging from bacteria to humans (Wang and Montell, 2007; Yau and Hardie, 2009). Organisms have Tasting light links energy from creation to adaptation

Polycombic ecological adaptation as a science, not a theory (2)

Evolutionary Constraints in the β-Globin Cluster: The Signature of Purifying Selection at the δ-Globin (HBD) Locus and Its Role in Developmental Gene Regulation Conclusion: … the results here presented indicate that purifying selection is driving not only HBD evolution but also its neighbor pseudogene, HBBP1. In the light of recent advances in the characterization of Polycombic ecological adaptation as a science, not a theory (2)

The human virome (revisited)

From October 2013: Describing the Silent Human Virome with an Emphasis on Giant Viruses “…viruses infect all domains of life, including bacteria, archaea and eukaryotes, and are found in all ecological niches [2]. This pleiotropic distribution on our planet allows viruses to play the role of ‘natural motors’ that drive global energy and nutrient cycling The human virome (revisited)

The Aquatic Ape: New evidence?

The Waterside Ape BBC Radio 4 Publicity Sir David Attenborough considers whether new evidence will help a once widely ridiculed theory of human origins move towards to mainstream acceptance. In 1960, the eminent Oxford marine biologist Sir Alister Hardy proposed a revolutionary idea: that our human ancestors had not started their existence on the wide The Aquatic Ape: New evidence?

Anthetical conclusions (2)

From Fertilization to Adult Sexual Behavior (1996) …ribosomal proteins S4X and S4Y (rpS4X, rpS4Y) are produced by sexually dimorphic genes whose protein products are sexually dimorphic. This suggests the possibility of subtle nuances in the ribosomal translation of at least some mRNA, in certain cell types (Fisher et al.,1990; Zinn et al., 1994). Small intranuclear Anthetical conclusions (2)