fine-tuning

Light energy-induced base pair changes (2)

See: Light energy-induced base pair changes (1) To help others move forward via the concept of energy-dependent biophysically constrained RNA-mediated protein folding and what is known about how virus-driven energy theft is linked to all pathology, see also: Subatomic Particles, Part 1: Leptons Subatomic Particles, Part 2: Baryons, the Substance of the Cosmos Subatomic Particles, Part 3: Mesons If you are not ready to start from the de novo creation of the energy in a hydrogen atom, you may need…

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Light energy-induced base pair changes (1)

Semisynthetic organisms and synthetic biology Unintended Consequences of Expanding the Genetic Alphabet Conclusion: …phototoxicity results presented herein using a human skin cancer cell line are intended to create awareness to the scientific community of the potential unintended consequences of expanding the genetic alphabet with unnatural nucleosides like those used in this work. Reported as:  Unintended consequences of creating the world’s first semisynthetic organism Excerpt: …the artificial base pair makes living cells more susceptible to damage from low doses of sunlight and…

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Genomic surveillance ends our world of RNA-mediated ecological adaptations

Why is this woman smiling? 1) Identifying Recent Adaptations in Large-Scale Genomic Data Senior author: Sabeti with co-author Rinn Excerpt: “As natural selection can only act on mutations that drive phenotypic variation…”. 2) Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak  Senior author: Sabeti. Excerpt: “Because many of the mutations alter protein sequences and other biologically meaningful targets, they should be monitored for impact on diagnostics, vaccines, and therapies critical to outbreak response.” 3) RNA and…

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Pheromones and cancer

Transcription Factor-MicroRNA-Target Gene Networks Associated with Ovarian Cancer Survival and Recurrence Excerpt: “MicroRNAs (miRNAs) are small, non-coding RNA molecules that bind to complementary sequences on target mRNA transcripts, and thus, regulate gene expression at the post-transcription stage. Transcription factors (TFs) are a different type of regulator. These proteins bind to specific DNA sequences in the promoter region, promoting or repressing transcription into mRNA, and thus, regulate genes at a pre-transcription stage [4]. TFs and miRNAs can regulate each other and…

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