fixation of amino acid substitutions

Natural selection for adaptation (2)

See first: Natural selection for adaptation (1) It’s been 20 days since biologically uninformed science idiots reported everything known to intelligent serious scientists about natural selection for biophysically constrained viral latency and ecologically adapted phenotypes in the context of cryptic transmission. See: Altered chromatin states drive cryptic transcription in aging mammalian stem cells 8/2/21 This nonsense was reported on 8/3/21 as Aging Cells May Lose Control of Where an mRNA Sequence Starts The cell’s machinery ‘reads’ DNA sequences in sets…

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MicroRNA-mediated population control (6)

7/29/21 I linked fixation of one amino acid substitution, EDAR V370A from the diet of human populations in East and central China to the New World during the past 5-10K years of ecological adaptations via https://nature.com/news/past-5-000-years-prolific-for-changes-to-human-genome-1.11912 WHO still hates me for doing that. How? “The findings confirm their earlier work suggesting that the majority of variants, including potentially harmful ones, were picked up during the past 5,000–10,000 years.” Clearly, there has never been support for stupid theories about the emergence…

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Pheromones protect us from viruses (9)

It may be a form of insanity that prevents theorists, atheists, and Communists from addressing the facts that have been detailed in the context of: Direct Observation of Protonation State Modulation in SARS-CoV-2 Main Protease upon Inhibitor Binding with Neutron Crystallography 3/23/21 …a class of agents called covalent peptidomimetic inhibitors that work by using strings of unnatural amino acids to bind to specific target proteins. See for instance:  A two-amino acid change in the hemagglutinin of the 1918 influenza virus…

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Creationism, Communism and Corruption (1)

The Chinese Communist Party (CCP) consistently failed to address facts that link the National Microbiome Initiative to the Precision Medicine Initiative via what people eat and what is known to all intelligent serious scientists about the microRNA-mediated pheromone-regulated genetic processes of reproduction. See for instance more than 113,000 indexed published works that mention “microRNA.” See for example: Multiple microRNAs regulate tacrolimus metabolism through CYP3A5 12/18/20 MicroRNAs are novel regulators of tacrolimus metabolism and the… …CYP3A5 gene polymorphism accounts for the…

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From nitrogen atoms to ecosystems in all living genera

Summary: The “tiny machines” that “massacre viruses” link the creation of the anti-entropic virucidal energy of sunlight to the pheromone-controlled physiology of reproduction in all living genera via the nitrogen-dependent weekend resurrection of the bacterial flagellum in P. fluorescens. See: Virus-mediated archaeal hecatomb in the deep seafloor We show here for the first time the crucial role of viruses in controlling archaeal dynamics and therefore the functioning of deep-sea ecosystems, and suggest that virus-archaea interactions play a central role in…

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Methylation and the innate immune system (2)

Single methyl groups can act as toggle switches to specify transmembrane protein-protein interactions These results highlight the high intrinsic specificity of TMD interactions, demonstrate that a single methyl group can dictate specificity, and define the minimal chemical difference that can modulate the specificity of TMD interactions and the activity of transmembrane proteins. RNA-directed DNA methylation is energy-dependent. The “minimal chemical difference” is linked from the quantized energy of virucidal light to all biophysically constrained biodiversity via base pair changes, single…

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Polycombic ecological adaptation as a science, not a theory (2)

Evolutionary Constraints in the β-Globin Cluster: The Signature of Purifying Selection at the δ-Globin (HBD) Locus and Its Role in Developmental Gene Regulation Conclusion: … the results here presented indicate that purifying selection is driving not only HBD evolution but also its neighbor pseudogene, HBBP1. In the light of recent advances in the characterization of the β-globin cluster, we propose that the complex patterns of diversity observed in this genomic region arose from distinct functional constraints related with the intricate…

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