RNA-Mediated

Summary: Slide number 6 clearly states the “Levels of Biological Organization” that the “NSF’s 10 Big Ideas” finally places into the context of what has been known to all serious scientists for more than a century. Simply put, Hugo de Vries definition of mutation (sudden energy jumps) should never have been accepted as anything besides the claim of a biologically uninformed science idiot. Instead, the definition bastardized every aspect of what is now known about biophysically constrained viral latency and…

The next reformation: 500 years too late? (2)

October 31, 2017

Adaptations, base editing, Ecology, RNA Directed, RNA editing

The problem for those who use definitions is that everything known about the links from food energy-dependent changes in electrons to ecosystems must now be ignored. Last week, publications in Nature and in Science linked energy-dependent changes in base editing to RNA editing, which means that all the ignorance of biologically uninformed theorists can be placed into the context of Feynman’s claims about “human idiocy.” See also: RNA editing and alternative splicing: the importance of co-transcriptional coordination Apparently, the theorists…

Energy-dependent structure and function: Until death (3)

October 11, 2017

Autophagy, RNA Directed

Energy-dependent structure and function: Until death (2) The COMT Val158Met polymorphism supposedly is not found in species other than humans See: Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles This is also the first study establishing the COMT*L allele as the derived allele unique to humans. Other organisms do not commit suicide. That suggests the human specific COMT Val158Met substitution may be important to those who know very little about suicide prevention. For instance, see: The catechol-o-methyltransferase Val158Met polymorphism…

Energy-dependent structure and function: Until death (2)

October 11, 2017

Autophagy, RNA Directed

Energy-dependent structure and function: Until death (1) Terry Crews details alleged sexual assault by ‘high level’ Hollywood exec “This whole thing with Harvey Weinstein is giving me PTSD. Why? Because this kind of thing happened to ME…” Crews tweeted Tuesday. This claim helps to link the celebrity status of Hollywood victims like Robin Williams to the suicide rate in veterans who have returned from military service overseas with viruses. The viruses clearly link energy-dependent changes in the microRNA/messenger RNA balance…

Energy-dependent structure and function: Until death (1)

October 11, 2017

Autophagy, Diseases & Disorders, Human Brain, Human Pheromones, Model Organisms, Neuronal Plasticity, RNA Directed, RNA-mediated epigenetic regulation of gene expression, Variations

The structure-energy landscape of NMDA receptor gating …using single-molecule Forster resonance energy transfer (smFRET), we map the energy landscape of the first transmembrane segment of the Rattus norvegicus NMDA receptor under resting and various liganded conditions. These results show kinetically and structurally distinct changes associated with apo, agonist-bound, and inhibited receptors linked by a linear mechanism of gating at this site. Furthermore, the smFRET data suggest that allosteric inhibition by zinc occurs by an uncoupling of the agonist-induced changes at…

Energy-dependent epigenetic translation to mRNA stability (3)

May 15, 2017

Adaptations, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA-directed DNA methylation, RNA–Mediated Epigenetic Heredity, Variations

Energy-dependent epigenetic translation to mRNA stability (2) Energy-dependent epigenetic translation to mRNA stability (2) See for comparison this treatise on climate change packaged as information on the evolution of a flying snake. Fossil ‘winged serpent’ is a new species of ancient snake At the time that Zilantophis dwelled there, the site was a sinkhole surrounded by forest, attracting a variety of animals. The local fauna included ancient representatives of familiar North American creatures such as bears, beavers and salamanders. Others…

Energy as information and constrained endogenous RNA interference (4)

May 8, 2017

Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Physics, RNA Directed, RNA interference, RNA–Mediated Epigenetic Heredity, Variations

4 Comments

Premise: Sunlight is the energy as information that is required to link endogenous RNA interference to healthy longevity Counter claim: The Quantum Thermodynamics Revolution: Information theory Understanding entropy as a subjective measure allows the universe as a whole to evolve without ever losing information. Precision Medicine virtual conference, Feburary 22-23, 2017 Title: Energy as information and constrained endogenous RNA interference James V. Kohl RNA-mediated.com jvkohl@bellsouth.net Abstract describing the poster Narrative: The term microRNA has been used in 58,000 indexed…

Draining the academic swamp of parasites

May 3, 2017

Adaptations, Autophagy, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA-directed DNA methylation, Variations

National Academies Revise Conflict of Interest Policy The proposed changes follow revelations in recent years that committee members preparing reports for the Academies did not disclose industry relationships. By Ashley P. Taylor | May 3, 2017 Excerpt: They are also thinking about including not only current activities and relationships, as they do now, but past ones when determining whether or not a committee member has a COI. See for comparison: Ian Hodder: Çatalhöyük, Religion & Templeton’s 25% My comment: Past…

Functionally interdependent editing and methylation

April 4, 2017

Adaptations, Autophagy, base editing, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations

Editing and methylation at a single site by functionally interdependent activities …cytosine 32 in the anticodon loop of Trypanosoma brucei tRNAThr is methylated to 3-methylcytosine (m3C) as a pre-requisite for C-to-U deamination. Formation of m3C in vitro requires the presence of both the T. brucei m3C methyltransferase TRM140 and the deaminase ADAT2/3. Once formed, m3C is deaminated to 3-methyluridine (m3U) by the same set of enzymes. ADAT2/3 is a highly mutagenic enzyme4, but we also show that when co-expressed with…

Cytosis: Biology Content

April 4, 2017

Adaptations, Diseases & Disorders, Ecology, Light Energy, Model Organisms, RNA Directed, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations