G-quadruplexes

Epistemic corruption (7)

NYU may hire biologist pushed out of MIT, Whitehead for sexual misconduct 4/25/22 “Civility Rules.” “A mob feels compelled to stridently ‘cancel’ someone with different thoughts, or to baselessly attack an individual in ways that can be difficult to disprove,” he wrote. “This is tolerated in academia, where nameless accusers can disparage a colleague’s science and life’s work, even when their claims are unfounded.” Grossman declined to comment further. Eric Lander, former science advisor to Joe Biden, became a victim…

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MicroRNA-mediated existential threats (3)

“Footprints of Multiple Interspecies Re-assortment Events” (4/16/18) link the failed efficacy of COVID19 vaccines,  to the microRNA-mediated future of humanity via patents held for therapeutic solutions by Thomas E. Eichim et al., in the context of former President Trump’s claim on 4/23/20 about light-activated protein folding chemistry and Characteristics of the MicroRNA Expression Profile of Exosomes Released by Vero Cells Infected with Porcine Epidemic Diarrhea Virus  (indexed on 4/23/22) Details: Exosomes… contain regulated microRNA (miRNA), allowing them to function in…

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microRNA-mediated replication timing (4)

See first: microRNA-mediated replication timing (1) 6/17/21 microRNA-mediated replication timing (2) 6/27/21 microRNA-mediated replication timing (3) 6/29/21 Non-B DNA: a major contributor to small- and large-scale variation in nucleotide substitution frequencies across the genome 1/15/21 was reported on 6/29/21 as Study provides first genome-wide evidence for functional importance of unusual DNA structures Some regions of the human genome where the DNA can fold into unusual three-dimensional structures called c (G4s) show signs that they are preserved by natural selection. The…

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NSF’s parrot and other parrots

Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964) “Isolated thymus nuclei transport amino acids into an intranuclear pool by a process which seems to depend on energy from nuclear ATP synthesis (20).” The energy must be biophysically constrained: Long-range coherence and energy storage in biological systems (1968) Human Pheromones: Linking Neuroendocrinology and Ethology (revisited) (2010) Slide # 6 attests to the fact that the levels of biological organization…

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