gene duplication

Energy-dependent de novo creation and neurogenesis (2)

See also: Energy-dependent de novo creation and neurogenesis 12/7/16 Atlas of the RNA universe takes shape Excerpt: MicroRNA are very mysterious. They are really relics of the RNA world—pieces of RNA that are highly reactive, very small and which pair and bind other RNA and facilitate catalytic reactions,” Mangone says. “We don’t know much about them—where they come from or how they regulate gene expression, but they are very misregulated in many diseases. See also: Nutrient-dependent/pheromone-controlled adaptive evolution: a model…

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DNA repair via junk DNA (2)

See also: DNA repair via junk DNA (1) Recently Evolved Genes Identified From Drosophila yakuba and D. erecta Accessory Gland Expressed Sequence Tags (2006) Reported in Singer (2015) as: In 2006, Begun found some of the first evidence that genes could indeed pop into existence from noncoding DNA. Singer’s claim that genes automagically pop into existence is consistent with Masatoshi Nei’s conclusion in: Mutation-Driven Evolution …genomic conservation and constraint-breaking mutation is the ultimate source of all biological innovations and the…

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Stress-linked population-level history dependence

The Science of President Trump My comment: Trump is not a president. He may be the Republican front-runner. In any case, attempts to portray him as a president in the context of “science” must be viewed in the context of pseudoscientific nonsense and media misrepresentations. Many political views on science are unrealistic because they are based on the pseudoscientific nonsense touted by neo-Darwinian theorists. If someone thinks that nutrient-dependent pheromone-controlled multicellularity automagically evolved, their thought processes have probably already been…

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RNA methylation, RNA-directed DNA methylation, learning and memory

sink testing Lab medicine The illegal practice of providing false test results on clinical specimens–eg, vials of blood, urine specimens, that were deliberately discarded–ie, down the sink, without actually testing them Pylori Story #1: Acid Attack Pylori Story #2: Journey to the Center of the Stomach The “Modern Synthesis” is analogous to sink testing in the medical laboratory. See for example: Replace the Modern Synthesis (Neo-Darwinism): An Interview With Denis Noble Excerpt: [W]hat Haldane, Fisher, Sewell Wright, Hardy, Weinberg et…

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Life history transitions and RNA-mediated survial

The Endospore-Forming Pathogen Bacillus cereus Exploits a Small Colony Variant-Based Diversification Strategy in Response to Aminoglycoside Exposure Conclusion:  Thus, consideration of SCVs as a new, yet unexplored lifestyle of B. cereus within the common ecological niches, in which antibiotic-active substances produced by competitive microorganisms, plants, and invertebrate/vertebrate vectors might potentially also induce this persistent life-form of B. cereus, opens a panoply of research questions to be followed up. Reported as: Lifestyle switching – Bacillus cereus is able to resist certain antibiotic therapies…

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Ecological adaptations you cannot live without

Follow up to: Stress-perturbed mitochondrial dysfunction Summary: Bruce McEwen and others are taking the concept of RNA-mediated amino acid substitutions in cell type differentiation to a new level. They will force neo-Darwinian theorists to differentiate between mutations and amino acid substitutions. After February 14, 2016, if you still don’t know the difference, you may be subjected to ridicule by serious scientists who know how to link atoms to ecosystems in the context of biologically-based cause and effect. Also, the “Precision…

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Receptor methylation controls behavior

The protein arginine methyltransferase PRMT5 promotes D2-like dopamine receptor signaling Excerpt 1) The addition of a methyl group to an arginine residue can remove a hydrogen bond donor and decrease the electrostatic surface potential at the residue, resulting in a change in size and hydrophobicity that can affect its interaction with binding partners (21). Excerpt 2) Together, these results led us to propose that arginine methylation promotes D2-like dopamine receptor signaling and that this mechanism of receptor regulation is conserved…

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Models are not theories (2)

MicroRNA-encoded behavior in Drosophila Editor’s summary: MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene activity. They repress expression through complementary base pairing interactions with target messenger RNAs. MiRNAs are involved in regulating many cell and developmental processes. Picao-Osorio et al. find that miRNAs can also control behavior in the fruit fly Drosophila. My comment: Ridiculous claims from 1) We are all mutants and from 2) Mutation-Driven Evolution can now be placed into the context of what is known to…

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Can veterans and other prisoners escape pseudoscience?

Combating Evolution to Fight Disease “…an important gap is being filled by molecular understanding of the genesis of variation that confers the ability to evolve.” Inside the drive to collect DNA from 1 million veterans and revolutionize medicine Excerpt 1) The U.S. Department of Veterans Affairs is gathering blood from 1 million veterans to sequence their DNA. This is one of the most ambitious projects ever undertaken to understand our genome. Excerpt 2) In January, President Obama announced plans for…

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Mutated mitochondrial genes vs Supercoiled DNA

Genetics probe identifies new Galapagos tortoise species Excerpt 1) Their paper1, published in PLoS ONE on 21 October, is the culmination of a decade of work. It presents 25 mitochondrial DNA mutations that reliably separate the two groups. Excerpt 2) “The species concept is a fuzzy one,” he says. “Call them whatever you want, I don’t care. What is important is that people realize there is hidden diversity.” My comment: The editors at “Nature” seem to typically support the misrepresentations…

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