Gene Editing

Enzyme-constrained interethnic biodiversity (2)

See: The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression The links from the anti-entropic virucidal energy of the sun are obvious. Plant microRNAs link the physiology of pheromone-controlled reproduction in soil bacteria from the physiology of food energy-dependent reproduction in animals to the pheromone-controlled physiology of reproduction in all animals via biophysically constrained viral latency, which is mediated by the fixation of amino acid substitutions. See Schrodinger (1944) What is life? In the forward…

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Evolutionary congruence (losers) vs ecological adaptation (winners)

Nuclear and Plastid DNA Sequence-based Molecular Phylogeography of Salvadora oleoides (Salvadoraceae) in Punjab, India Reveals Allopatric Speciation in Anthropogenic Islands Due to Agricultural Expansion This is the first DNA-sequence based phylogeographic assessment of Salvadora in the world. Sequence based phylogeographic assessment of tropical tree species is a relative rarity and in India, such investigations are almost non-existent.   Kalevi Kull: Censorship & Royal Society Evo Event Nobody wants to belong to the party of losers. One of the best strategies…

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Hard Science vs the neo-Darwinian “magic box”

Summary: Identical nucleotide sequences link energy-dependent changes in binding sites to different amino acids in different proteins. The binding sites are conserved in the orthologous mammalian genes. The in vivo structure of biological membranes and evidence for lipid domains Scientists investigate how the sense of smell works in bacteria Biogenic non-crystalline U(IV) revealed as major component in uranium ore deposits As presciently predicted in the works of Richard Feynman and Bruce McEwen, bacteria feed on something that allows them to…

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RNA-mediated terrorism

Obama Advisers Urge Action Against CRISPR Bioterror Threat For the past two decades, the government has focused its biodefense efforts on a list of known pathogens—such as anthrax, smallpox, and Ebola—declared by the Department of Health and Human Services and Department of Agriculture to have the “potential to pose a severe threat to public health and safety.” Government-funded research on these pathogens receives special scrutiny, and the National Institutes of Health limits researchers from conducting experiments that could make certain…

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The natural success of RNAi and failed treatment

see my other blog posts on m6A Dynamics of Human and Viral RNA Methylation during Zika Virus Infection Excerpt: …ZIKV infection alters m6A location in mRNAs, methylation motifs, and target genes modified by methyltransferases. Our results identify a mechanism by which ZIKV interacts with and alters host cell functions. Reported as: Zika virus infection alters human and viral RNA Excerpt: When Zika virus infects a human cell, Rana’s team found, the cell modifies viral RNA with m6A as a means…

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Did “Nature” kill Steve Jobs? (3)

So Many Research Scientists, So Few Openings as Professors Excerpt: Even someone as brilliant as Emmanuelle Charpentier, who in 2015 became head of the Max Planck Institute for Infection Biology after a momentous discovery in gene editing, spent the previous 25 years moving through nine institutions in five countries. My comment: Why did she move around so much when in the same year, on 07/02/2015, George Church and colleagues filed a patent application for “RNA-Guided Human Genome Engineering.” Excerpt: Repetitive…

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Natural cooperation and Evolution 2.0

More than 45,000 published journal articles indexed on PubMed already contained the term microRNA before evolutionary theorists declared the microRNAs were linked from their emergence to all biodiversity via mutations and evolution in: MicroRNA mechanisms of action: what have we learned from mice? Conclusion:  We speculate that miRNAs emerged during evolution to increase the complexity of gene regulation, thereby contributing to the diversity of organisms. See for comparison: ‘Natural cooperation’ is nutrient dependent and pheromone controlled See also: Evolution 2.0…

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