gene expression

Coherently organized healthy longevity (1)

July 31, 2020
James Kohl
Alternative Splicings, Cytosis, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA interference, What's in the News
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A large-scale binding and functional map of human RNA-binding proteins [RBPs] 7/29/20 We describe the spectrum of RBP binding throughout the transcriptome and the connections between these interactions and various aspects of RNA biology, including RNA stability, splicing regulation and RNA localization. These data expand the catalogue of functional elements encoded in the human genome by the addition of a large set of elements that function at the RNA level by interacting with RBPs. Reported as: ENCODE consortium identifies RNA…

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CDC’s ignorance: from roots to shoots (2)

March 25, 2020
James Kohl
Adaptations, biophotonics, Diseases & Disorders, Ecology, RNA Directed
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See: CDC’s ignorance: From roots to shoots (1) Excerpt: Is there a corporate scheme that underlies the ignorance at the CDC? Robert H. Lustig clearly states that he does not believe in conspiracy theories, and neither do I. I’ve detailed the facts that link light-activated carbon fixation from the Creation of ATP to RNA interference and the patented cure for all virus-driven pathology in a series of publications and presentations during the past 25 years. Unfortunately, the microRNA-mediated cure has…

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MicroRNA-mediated alternative splicing (revisited)

June 7, 2018
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Physics, RNA Directed, RNA editing, RNA interference, RNA-directed DNA methylation, RNA–Mediated Epigenetic Heredity, Subatomic
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Building one molecule from a reservoir of two atoms reported as: Cold chemistry with two atoms. They linked differences in the energy of photons from two different wavelengths of light, 700 nm and 976 nm, to the creation of the molecule NaCs*. They were able to detect molecule formation in the context of atom loss and NaCs* vibrational levels near the dissociation threshold. Detecting resonances that have not been previously observed appears to be the link from quantum physics to…

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Corporate owned microRNA-mediated biodiversity

June 7, 2018
James Kohl
Adaptations, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Physics, RNA interference
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Corporate control and global governance of marine genetic resources Who owns ocean biodiversity? All biodiversity is quantized energy-dependent and RNA-mediated in the context of the physiology of reproduction and pheromone-controlled RNA interference (RNAi) . Naturally occurring light-activated RNAi ensures viral latency, which helps to ensure healthy longevity. George Church et al, own this patent on RNA interference, which suggests that he and others own all biodiversity in the context of the Virus-mediated archaeal hecatomb in the deep seafloor and patent…

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The MicroRNAome Strikes Back: A Sokalian hoax (8)

January 30, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, Cytosis, Diseases & Disorders, Ecology, RNA Directed
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Defeating Diseases with Energy (January 9, 2018) is a thinly disguised attempt to help corporate giants continue to promote ridiculous neo-Darwinian theories. It features the works of Douglas C. Wallace, who failed to link the virus-driven degradation of messenger RNA to all pathology since he published: Neoplastic transformation is associated with coordinate induction of nuclear and cytoplasmic oxidative phosphorylation genes (1990). Similar analysis of a cervical carcinoma (HeLa), fibrosarcoma (HT1080), and an Epstein-Barr virus (EBV)-transformed lymphoblastoid line (EBV-L) revealed that…

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Electron cloud superimposed on the yin yang symbol

The “walking fish” walks straight from quantum physics to quantum souls (4)

January 3, 2018
James Kohl
Adaptations, Alternative Splicings, Autophagy, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA–Mediated Epigenetic Heredity, Variations
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Excerpt: During the past 21 months, others have either learned nothing about microRNAs or they have ignored the fact that virus-driven energy theft is not the same as energy dissipation in the context of food energy (the quantized energy as information that is used by viruses to create the amino acid substitutions that stabilize their RNA and DNA). The dark side of the new popularity of cryo-electron microscopy …we need to stand together as a field, and support our colleagues…

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Denying Creation via RNA-directed DNA methylation

November 22, 2017
James Kohl
Adaptations, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA–Mediated Epigenetic Heredity, Variations
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Summary: Epigenetic mechanisms did not evolve.  DNA methylation is food energy-dependent and RNA-directed. Phenotypes are not fixed by genetics. The food energy-dependent RNA-directed DNA methylation of all organized genomes is biophysically constrained by the metabolism of food to pheromones, which control the physiology of food-dependent reproduction. On the day after he posted content on the refutation of Karl Popper’s nonsense and the pseudoscientific nonsense touted in every aspect of neo-Darwinian theory, antagonist Jay Feierman posted this to the Human Ethology…

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Schrodinger’s answer to Schrodinger’s question

November 21, 2017
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Light Energy, microRNA editing, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations, What's in the News
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There is no such thing as de novo control of electrons or self-assembly. Answering Schrödinger’s question: A free-energy formulation The free-energy principle (FEP) is a formal model of neuronal processes that is widely recognised in neuroscience as a unifying theory of the brain and biobehaviour. More recently, however, it has been extended beyond the brain to explain the dynamics of living systems, and their unique capacity to avoid decay. They don’t understand the question that Schrodinger answered. He linked the…

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Epigenetic facts vs variable recombination theories

November 7, 2017
James Kohl
Adaptations, Alternative Splicings, base editing, Diseases & Disorders, Ecology, Human Pheromones, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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6/14/13 Nutrient-dependent/pheromone-controlled adaptive evolution: a model ….the model represented here is consistent with what is known about the epigenetic effects of ecologically important nutrients and pheromones on the adaptively evolved behavior of species from microbes to man. Minimally, this model can be compared to any other factual representations of epigenesis and epistasis for determination of the best scientific ‘fit’. 7/25/13 Jay R. Feierman: Variation is not nutrient availability and the something that is doing the selecting is not the individual…

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Host-derived creation of all pathology (2 of 2)

August 29, 2017
James Kohl
Adaptations, Alternative Splicings, base editing, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA editing, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Subatomic, Variations, What's in the News
One Comment

Summary: All serious scientists know that all epigenetic diversity is food energy-dependent and biophysically constrained by the pheromone-controlled physiology of reproduction. See for comparison: Jay R. Feierman: “Variation is not nutrient availability and the something that is doing the selecting is not the individual organism. A feature of an educated person is to realize what they do not know. Sadly, you don’t know that you have an incorrect understanding [of] Darwinian biological evolution.” A Bacterial Messenger Molecule Extends Healthspan …indole,…

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