Gene regulatory networks

Pseudoscientists hate what science explains! (3)

See also: Pseudoscientists hate what science explains (2) Summary: In addition to germline silencing via information transfer to the physical landscape of supercoiled DNA, multicopy transgene arrays are linked from changes in the microRNA/messenger RNA balance to variation in their somatic expression level. That fact helps to establish the difference between healthy longevity and pathology across generations. Problems with DNA replication can cause epigenetic changes that may be inherited for several generations My summary: The polycomb repressive complex 2, additional…

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Anti-entropic energy and the “Music of Life”

TRIM28 Controls a Gene Regulatory Network Based on Endogenous Retroviruses in Human Neural Progenitor Cells … we report the existence of a TRIM28-controlled gene regulatory network based on ERVs that is active in hNPCs. Our findings open up for several exciting future studies on the role of ERVs as potential drivers of human brain evolution, their contribution to individual variation, and the implication in human brain disorders. All gene regulatory networks are energy-dependent. They must link the sun’s anti-entropic virucidal…

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How did the innate immune system evolve?

Sexually Antagonistic Male Signals Manipulate Germline and Soma of C. elegans Hermaphrodites Abstract excerpt: Why would a system exist that reduces the vigor of potential mates prior to mating? Addressing this question could provide insights into mechanisms and evolution of sexual conflict and reveal sensory inputs that regulate aging. Highlights excerpt: An unknown signal accelerates larval development, specifically the onset of puberty Reported as: Male chemistry primes females for reproduction—but at a cost “There is a fine balance between reproduction and…

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Imagining that data historically supports evolutionary theory

1) Arguments in the evo-devo debate: say it with flowers! Abstract excerpt: A key question in evolutionary developmental biology is how DNA sequence changes have directed the evolution of morphological diversity. The widely accepted view was that morphological changes resulted from differences in number and/or type of transcription factors, or even from small changes in the amino acid sequence of similar proteins. My comment: This is the first time I have seen anyone claim that the “…small changes in the…

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