Genes and the Human Condition

Becoming biologically informed

RNA-mediated pathogenic mechanisms in polyglutamine diseases and amyotrophic lateral sclerosis Abstract excerpt: In this article, we describe various common RNA toxicity pathways, namely epigenetic gene silencing, nucleolar stress, nucleocytoplasmic transport, bi-directional gene transcription, repeat-associated non-ATG translation, RNA foci formation and cellular protein sequestration. Journal article conclusion: Although protein toxicity was considered to play a major Becoming biologically informed