genetic networks

Biologically uninformed biologists fight back and lose

Novel layers of RNA polymerase III control affecting tRNA gene transcription in eukaryotes 22 Feb 2017 A subset of tRNA genes shows low responsiveness to both environmental and cellular signals. Notably, this group contains at least one tRNA for each amino acid. Together these findings suggest the existence of a basal subset of housekeeping tRNA genes [36]. This concept is consistent with the mode of Maf1-mediated repression of actively transcribed tRNA genes in human cells subjected to serum starvation [104].…

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Bill Gates refutes theistic evolution (sequel)

See: Bill Gates refutes theistic evolution See also: Gate-controlled conductance switching in DNA Conclusion: Our work demonstrates one can introduce an active control to DNA conductance by modifying a base with a redox group, and switch the DNA conductance reversibly between two levels by oxidizing or reducing the redox group with an EC gate. This strategy could be implemented in more sophisticated DNA nanostructures for active device building blocks. As the DNA conductance is an indicator of the molecule in…

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Bill Gates refutes theistic evolution

See: Bill Gates refutes theistic evolution (prequel) See for comparison: Our 2017 Annual Letter Warren Buffett’s Best Investment By Bill and Melinda Gates | February 14, 2017 Malnourished children can be getting enough calories, but not the right nutrients. That makes them more susceptible to conditions like pneumonia or diarrhea—and more likely to die from them. If malnourished children are not getting the right nutrients, they focused too much on vaccines and not enough on what is known about nutritional…

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May the anti-entropic force of sunlight be with you

I added a video track to the audio track that already accompanies this presentation. See also: High-Power Actuation from Molecular Photoswitches in Enantiomerically Paired Soft Springs Reported as: Molecular switch drives powerful movement by opposing twisting helices Inspired by the evolutionary strategies that support the movement of plants, the team headed by Stephen P. Fletcher at the University of Oxford (UK) and Nathalie Katsonis at the University of Twente (Enschede, Netherlands) joined together two strips of liquid-crystal elastomers into a…

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Dobzhansky 1973 and precision medicine (5)

See: Dobzhansky 1973 and precision medicine (4) Microenvironmental autophagy promotes tumour growth …non-cell-autonomous autophagy is induced both in the tumour microenvironment and systemically… transformed cells engage surrounding normal cells as active and essential microenvironmental contributors to early tumour growth through nutrient-generating autophagy. Non-cell autonomous autophagy links non-random natural selection for codon optimality from the nutrient energy-dependent pherormone-controlled physiology of reproduction to biophysically constrained RNA-mediated protein folding chemistry via fixation of amino acid substitutions in supercoiled DNA. The supercoiled DNA links…

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Trump’s appeal to common sense (2)

See: Trump’s appeal to common sense Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation To our knowledge, this is the first study to use a genetic mouse model to simultaneously map Gpr182 localization patterns and elucidate novel physiological functions for the negative regulation of intestinal proliferative capacity, especially during regeneration and adenoma formation. Future studies to identify the ligand for this exciting and physiologically relevant orphan GPCR [G protein-coupled receptor] will shed light on its tractability as…

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Autophagy is the antiphage defense strategy

The “Antiphage Defense Strategy” in Vibrio anguillarum is called autophagy by many serious scientists. It links nutrient energy-dependent pheromone-controlled quorum sensing to viral latency, healthy longevity, symbiosis, reproduction, and biodiversity from microbial species to humans. For an evolutionary approach to energy-dependent autophagy that fails to address any aspect of how virus-driven energy theft causes all pathology see: (12/7/16) Part I: Living together: The symbiosis of host-microbial interactions (12/7/16) See also: 12/7/16 ….McFall-Ngai tells the story of a symbiosis between the…

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Epigenetically effected energy-dependent fluorescence (2)

We are just trying to understand your hypothesis. Peter Berean has wasted more of my time that nearly anyone else I have encountered, and he still claims my model is a hypothesis. On October 14, 2016 I asked: How can you or anyone else tell the difference between a secular humanist and an old earth creationist? For example, I can compare both sects to young earth creationists who have linked everything known about nutritional epigenetics to healthy longevity and everything…

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Epigenetics and autophagy vs mutations and evolution (7)

RNA interference (RNAi) fails to protect all cell types from virus-driven energy theft. The effect on some cell types cannot be controlled. That’s because nutrient energy-dependent endogenosymbiosis and the pheromones-controlled physiology of reproduction protect the organized genomes of species from microbes to humans. Billions of waster dollars have been spent with no end to the waste in sight — until the Trump administration stops it. As that begins to happen, see: tRNA-mediated codon-biased translation in mycobacterial hypoxic persistence (open access)…

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Nutrient-dependent autophagy

Autophagy: cellular and molecular mechanisms Excerpt: Autophagy is a self-degradative process that is important for balancing sources of energy at critical times in development and in response to nutrient stress. Autophagy also plays a housekeeping role in removing misfolded or aggregated proteins, clearing damaged organelles, such as mitochondria, endoplasmic reticulum and peroxisomes, as well as eliminating intracellular pathogens. My comment: Autophagy is energy-dependent See for example: Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency…

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