The eternal significance of microRNAs (8)

Use of definitions in attempts to explain any aspect of species-specific biophysically constrained cell type differentiation and aging has been replaced by the use of model systems of biological processes.  Biological processes can be compared to so-called “evolutionary processes” to show that only biological processes need to be considered in the context of Darwin’s “conditions of life” or answers to the the question  What is Life? Schrödinger (1944). K. L. Mettinger et al. (eds.), Exosomes, Stem Cells and MicroRNA, Advances…

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Irreconcilable differences: food energy vs de novo assembly

Developmental dynamics and contemporary evolutionary psychology: status quo or irreconcilable views? Reply to Bjorklund (2003), Krebs (2003), Buss and Reeve (2003), Crawford (2003), and Tooby et Al. (2003). The authors argue that evolutionary psychology currently offers no coherent framework for how to integrate genetic, environmental, and experiential factors into a theory of behavioral or cognitive phenotypes. An evolutionary perspective on the systems of adaptive immunity We propose a revival of the concept of the ‘Big Bang’ of vertebrate immunity, arguing…

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Dispensing with all pseudoscientific nonsense about evolution (2)

Dispensing with all pseudoscientific nonsense about evolution (1) See also: Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk Reported as: Hundreds of Genomic Regions Linked to Age at Menarche Age at onset of puberty is affected by a combination of genetic, nutritional, and other environmental factors and that timing, in turn, is associated with risk of cancer later in life. Who will be next to link energy-dependent…

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Expunging the distinguished public

Royal Society Expunges Public From Evo Record Many of the attendee-participants were, in fact, more distinguished than many of the actual speakers. So the audience came to be heard as well as to listen. But the official recording (now posted) has been wiped clean of public comment — the most robust part of the meeting — and what we are left with, with few exceptions, is a series of academic lectures and old science. Thanks for continuing to make the…

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Energy-dependent RNA methylation (7)

“…viral latency is responsible for life-long pathogenesis and mortality risk…” – Lieberman (2016) My comment: Energy-dependent RNA-mediated amino acid substitutions are responsible for life-long healthy longevity and decreased mortality risk. See for comparison: How cancer was created by evolution Excerpt 1) But even though it is evolutionary processes that have made cancer such a problem, it is also evolutionary thinking that is now leading to pioneering treatments that could stack the odds against cancer and in favour of our health.…

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Wasted Templeton Funding (2)

See also: Wasted Templeton Funding (1) Templeton grant funds evolution rethink Excerpt: The extended evolutionary synthesis is a term coined in 2007 to imply that the preeminent current evolutionary theory, the so-called modern synthesis, needed to broaden its focus because it concentrated too much on the role of genes in evolution and lacked adequate incorporation of new insights from development and other areas of biology. My comment: That is an understatement! The problems with the so-called modern synthesis are perfectly…

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Non-mainstream scientist shares Nobel prize in Medicine

Youyou Tu is the 12th women awarded the Nobel Prize in Physiology or Medicine (2015) for her discoveries concerning a novel therapy against Malaria. Historical perspective: Lasker~DeBakey Clinical Medical Research Award Excerpt: Tu discovered a passage in the Handbook of Prescriptions for Emergencies (340 CE) by Ge Hong that referenced Qinghao’s malaria-healing capacity. It said “Take a handful of Qinghao, soak in two liters of water, strain the liquid, and drink.” She realized that the standard procedure of boiling and…

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Nutrient-dependent RNA interference

This David Sloan Wilson interview of Eva Jablonka reflects the desperation of evolutionary theorists. Jablonka claims there is no need to re-define “evolution.” She also places all prior claims about evolution into the context of “symbolic evolution.” She attests to the fact that “evolution” (e.g., change over time) will probably be re-defined to fit whatever anyone was taught to believe it might be. See: Beyond Genetic Evolution. A Conversation With Eva Jablonka Excerpt: “This is a good opportunity to move…

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Understanding cell type differentiation

The Wisdom of the Fly Crowds by Ed Yong Excerpt: “This is a landmark study of collective behaviour,” says Iain Couzin… “Never before has it been possible to unweave the intricate coding of social behaviour during collective decision-making.” When it comes to fruit flies, scientists…  can really start to understand the origins of collective behaviour—how genes in the fly’s neurons are activated, how those neurons process signals from the fly’s environment, and how they drive individual behaviours that, in turn,…

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Single-cell level assay of protein biosynthesis and degradation

High-throughput detection of miRNAs and gene-specific mRNA at the single-cell level by flow cytometry Excerpt: “We use this technique to show modulation of a microRNA critical for T-cell function, miR-155. We adapt this assay for simultaneous detection of mRNA and proteins by ImageStream technology.” Reported as: Technology breakthrough reveals cellular transcription process My comment: Their assay simultaneously detects epigenetically-effected changes in the miRNA/mRNA balance and proteins, which link nutrient-uptake to the physical landscape of DNA in the organized genomes of…

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  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, […]
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