genetics

From Precis to Proof in 6000 years

Religious texts, such as The Holy Bible appear to be like a Precis of works from God. He seems to be explaining energy-dependent creation in the context of what is currently known to serious scientists about biophysically constrained RNA-mediated protein folding chemistry, healthy longevity and RNA-mediated biodiversity. God made it perfectly clear, in advance, that all miraculous biodiversity is energy-dependent. Energy as information is the theme that extends to the weekend resurrection of the bacterial flagellum in P. fluorscens. Biologically…

Read More

80 years of causal analysis (1936 – 2016)

Roles of Mutation and Selection in Speciation: From Hugo de Vries [1902 definition of mutation] to the Modern Genomic Era Excerpt: …mutation is crucial in speciation because reproductive barriers cannot be generated without mutations. My comment: Chromosomal rearrangements link autophagy from energy-dependent changes in RNA-mediated amino acid substitutions and supercoiled DNA to all biodiversity via speciation. Some Principles of Causal Analysis in Genetics (1936) Extract: …high frequency radiation and particles of high velocity are very important components of the environment,…

Read More

Unconstrained mutations, Zika virus, Kallmann’s syndrome

Frequency and Types of Chromosomal Aberrations in the Patients with Hypogonadism Published December 11, 2014 Reported in Journals and Conferences on Genetics & Molecular Biology·Wednesday, September 7, 2016 See also: Epigenetics and Genetics of Viral Latency … viral latency is responsible for life-long pathogenesis and mortality risk… X Chromosome-Linked Kallmann Syndrome: Clinical Heterogeneity in Three Siblings Carrying an Intragenic Deletion of the KAL-1 Gene Received: December 18, 2002 Accepted: February 02, 2003 First Published Online: January 14, 2009 Kallmann syndrome…

Read More

The Aquatic Ape: New evidence?

The Waterside Ape BBC Radio 4 Publicity Sir David Attenborough considers whether new evidence will help a once widely ridiculed theory of human origins move towards to mainstream acceptance. In 1960, the eminent Oxford marine biologist Sir Alister Hardy proposed a revolutionary idea: that our human ancestors had not started their existence on the wide savannahs of Africa, but had become accustomed to living alongside water – swimming and diving in the shallows, collecting the abundant food, and learning to…

Read More

Lawless evolution: No physics

New leader of NIH’s research watchdog faces staff revolt Partin may be looking to NSF for ideas about how to handle charges of plagiarism. Although 81% of NSF’s research misconduct findings involve plagiarism, ORI has left most plagiarism allegations to institutions to handle. Plagiarism was so widespread more than 20 years ago that the co-author of my book said to ignore it. The continuation of the problem for two decades has left pseudoscientists in charge and put the claims serious…

Read More

Antithetical conclusions (7)

Streamlining the E.coli Genetic Code Once the E. coli genome is pared down to 57 codons, the seven blank codons can be reintegrated and used to introduce nonstandard amino acids, the researchers have proposed; this would open the door to creating a wider range of proteins for industrial applications. A recoded genome also imparts resistance to viral infection and can be used for biocontainment: the DNA incorporated from wild-type E. coli or viruses can’t be used to build proteins successfully…

Read More

Pseudoscientists ignore what serious scientists prove

Earlier today (8/14/16) I challenged a friend who stated that “scientists claim 65 million years of natural selection led from the demise of the dinosaurs to the evolution of humans.” I ineffectively tried to explain the difference between the claims of scientists, which are based on experimental evidence, and the claims of pseudoscientists, which are based on pseudoscientific nonsense. Last week, this same friend asked where the energy comes from that is released when hydrogen atoms are split. How did…

Read More

GC-rich neo-Darwinian train wreck

Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells Excerpt: In this study, we demonstrate direct cellular reprogramming to induced neuronal cells through targeted activation of endogenous genes. Excerpt: Moreover, a recent study demonstrated that reprogramming efficiency can be limited by divergence to a competing cell identity (Treutlein et al., 2016). The molecular mechanisms and practical consequences of these limitations are largely unknown. My comment: They demonstrate what naturally must occur to link…

Read More

From angstroms to ecosystems

How a happy moment for neuroscience is a sad moment for science Systems neuroscience is celebrating a landmark, but one that shows the way we do science is broken. Excerpt: These data are the first complete set of neural activity recordings released before publication. No papers preceded it; not even a report. Nothing. Just: here you go guys, the fruits of the joint labour of around 100 people over 4 years.” My comment: They released the information on June 13,…

Read More

The end of neo-Darwinism

Rapid bacterial infection test reduces antibiotic use Excerpt: The rapid tests detect C-reactive protein (CRP), a marker of infections caused by bacteria, in patients’ blood. A low level of CRP is suggestive of viral infection and therefore antibiotic treatment is not required. My comment: The level of one protein differentiates between a viral and a bacterial infection. That fact attests to claims that one RNA-mediated amino acid substitution in a virus increases its virulence. The major antigenic changes of the…

Read More