genetics

Biophotonics, glycobiology, quantized biodiversity

Historical perspective: From Fertilization to Adult Sexual Behavior Excerpt: Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may…

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Did “Nature” kill Steve Jobs? (2)

See also: Did “Nature” kill Steve Jobs? In my model of biophysically constrained energy-dependent protein folding chemistry and RNA-mediated cell type differentiation, the nutrient-dependent pheromone-controlled physiology of reproduction links the innate immune system to supercoiled DNA, which protects all organized genomes from virus-driven entropy. For comparison to my model, see: Evolution 2016 Videos (Indexed) Youtube videos Posters See also for comparison: Viruses Have Guided the Path of Human Evolution Excerpt: Whenever a viral epidemic tears through a community, there are…

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RNA methylation (revisited)

N 6-Methyladenosine (m6A) Methylation in mRNA with A Dynamic and Reversible Epigenetic Modification Excerpt: …the reversible and dynamic m6A RNA methylation, the most prevalent internal modification in mRNA, plays broad and key roles in diverse biological processes. Through the functional interactions with m6A methyltransferases, demethylases, and m6A-binding proteins, this epigenetic modification affects various aspects of RNA metabolism, including mRNA transcription, splicing, nuclear export, localization, translation and stability, and post-transcriptional regulate gene expression at the RNA level. Conclusion:  Indeed, breakthrough discoveries…

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Placing boundaries where none exist

Epigenome-wide Association Studies and the Interpretation of Disease -Omics Reported by Carl Zimmer in:  Growing Pains for Field of Epigenetics as Some Call for Overhaul Excerpt: these experts “…argue that in some cases, changes to epigenetic marks don’t cause disease, but are merely consequences of disease. My comment: What kind of biologically uninformed expert or science journalist continues to misrepresent what is known to serious scientists about all virus-driven pathology? See for comparison: Epigenetics and Genetics of Viral Latency Excerpt:…

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Innate immunity and multiplexing

Scientists Hope to Cultivate an Immune System for Crops by Carl Zimmer Excerpt: The complex microbial world in the soil may protect plants much like our immune system protects our bodies. My comment: The speed of light on contact with water links the sun’s quantized anti-antropic virucidal energy from the de novo creation of nucleic acid precursors to biophysically constrained RNA-mediated protein folding chemistry and supercoiled DNA, which protects all living genera from virus-driven energy theft and genomic entropy. See…

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Masters of deception about nature (2)

See my other blog posts on RNA methylation Thanks for your review of How Can Physics Underlie the Mind?: Top-Down Causation in the Human Context (The Frontiers Collection) Others linked the sun’s anti-entropic virucidal energy from energy-dependent changes in hydrogen-atom transfer in DNA base pairs in solution to supercoiled DNA, which protects all organized genomes from virus-driven energy theft and genomic entropy. Ellis comments on at least one of Schrodinger’s claims from “What is Life?” but he largely ignores the…

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Cracking the Olfactory Code?

What a smell looks like Excerpt:  This experiment was created so scientists could study how animals and humans use smells to navigate their surroundings. That question forms the heart of a new $6.4 million project, sponsored by the National Science Foundation and the White House Brain Initiative, called Cracking the Olfactory Code. My comment to the PBS site: Re: “Smell was part of very ancient evolution…. Bacteria use olfaction, single-celled organisms use olfaction, worms use olfaction.” The de novo creation…

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Energy-dependent creation and entropy

Theorists tend to use the term de novo when they don’t know. If they don’t know how energy-dependent structures and functions are created, functional structures are created de novo. See for example:  Lymphotoxin-Dependent B Cell-FRC Crosstalk Promotes De Novo Follicle Formation and Antibody Production following Intestinal Helminth Infection If theorists don’t know what causes mutations, the mutations are de novo mutations. See for example: Germline De Novo Mutations in GNB1 Cause Severe Neurodevelopmental Disability, Hypotonia, and Seizures My comment: The…

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Molecular Diagnostics: What is unprotected life? (2)

See also: Molecular Diagnostics: What is unprotected life? What is life when it is not protected from virus driven entropy Published on 30 Mar 2016. Presentated at Molecular Diagnostics on April 6 and 7, 2016 The poster also is available at Figshare POSTER (abstract) “The anti-entropic force of virucidal ultraviolet (UV) light links guanine–cytosine (G⋅C) Watson–Crick base pairing from hydrogen-atom transfer in DNA base pairs in solution to supercoiled DNA, which protects the organized genomes of all living genera from…

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Eugene V. Daev: Chronology

Introduction by Eugene Daev Since the very beginning, I suggested that state of stress, which accompanied by sharp hormonal changes (Selye, 1950), ought to have an effect at the genetic level. My group has focused on pheromonal destabilization of mouse genome. We used the urinary pheromones from conspecific males and/or females as sex-specific stressors. Cytogenetic pheromonal effects we discovered supported this idea. We showed the genetic effects (mutagenic and antimutagenic) in vital peripheral organs (bone marrow and germ cells) in…

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