genome

From quantum physics to quantum souls (4)

The long-range consequences of food energy-dependent social factors predictably link everything known about social odors called pheromones from the quantized energy in food to metabolism and biophysically constrained viral latency.  Sympatric speciation exemplifies what is known about how quantized energy links the pheromone-controlled physiology of reproduction to biophysically constrained viral latency in species from microbes to humans. From quantum physics to quantum souls (4)

Energy-dependent RNA methylation (8)

Multiplexing Genetic and Nucleosome Positioning Codes: A Computational Approach Mutation Monte Carlo method (MMC): Excerpt: The mutation moves change the bp sequence but keep the DNA configuration fixed. Both moves change the energy, Eq (1), of the two bp steps involved. My comment: Moves that change energy cost energy. Attributing energy-dependent changes in base pairs Energy-dependent RNA methylation (8)

Extensive molecular evidence vs ridiculous theories

Mosquito Genomes Galore Whole-genome sequences of 16 different mosquito species reveal rapid evolution and could inform malaria research. By Ruth Williams | November 27, 2014 Excerpt: “…mosquitoes are rapidly evolving, exhibiting high degrees of gene gains, losses, shuffling, and even transmission between closely related species.” It is the reports on rapid evolution of insects that Extensive molecular evidence vs ridiculous theories

More than a bag of chemicals?

From Fertilization to Adult Sexual Behavior (1996) Excerpt: “Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans…” My comment: How far can this model of RNA-mediated cell type differentiation go? What links the model More than a bag of chemicals?

Epigenetically-effected metabolic shifts and ecological adaptations

Epigenetics of Trained Innate Immunity: Documenting the epigenetic landscape of human innate immune cells reveals pathways essential for training macrophages. By Ruth Williams | September 25, 2014 [open access] Excerpt: “…they then analyzed genome-wide distributions of four epigenetic indicators of gene activity: DNAse hypersensitivity and three different histone modifications—trimethylation of histone H3 at lysine 4, Epigenetically-effected metabolic shifts and ecological adaptations

Nutrient-dependent pheromone-controlled exercise-induced physiques

How to explain exercise-induced phenotype from molecular data: rethink and reconstruction based on AMPK and mTOR signaling Excerpt: “…cellular and molecular phenotype for exercise capacity is always acquired from regular exercise or muscle contraction; it is absurd to use drug and gene modification…” My comment: What is known about RNA-mediated events shows that the slightest Nutrient-dependent pheromone-controlled exercise-induced physiques

Mechanisms that are not understood increase clarity

Science 12 September 2014: Vol. 345 no. 6202 pp. 1240-1241 DOI: 10.1126/science.1252966 Perspective RNA Function RNA and dynamic nuclear organization John Rinn1,2,3, Mitchell Guttman4 Excerpt: “While the mechanism for how lncRNAs establish these domains is not fully understood, it is becoming increasingly clear that lncRNAs are important at all levels of nuclear organization—exploiting, driving, and Mechanisms that are not understood increase clarity

A relatively young branch of science called epigenetics

Epigenetics: genes, environment and the generation game New research claims that environmental factors affect not just an individual’s genes but those of their offspring too. Diabetes, obesity – even certain phobias – may all be influenced by the behaviour of our forebears by Angela Saini, The Observer, Saturday 6 September 2014 Excerpt 1): “…she was A relatively young branch of science called epigenetics