First comprehensive profile of non-protein-coding RNAs in human cancers Excerpt: Our study provides convincing evidence that dysregulation of lncRNAs takes place at multiple levels in the cancer genome and that these alterations are strikingly cancer-type specific,” Zhang concludes. “We have laid the critical groundwork for developing lncRNA-based tools to diagnose and treat cancer in new … Bird watchers and RNAs in cancers
The origin of the language of life Excerpt: It would be very interesting if the echoes of primordial events still resonated within the fabric of the biology of today”, concludes Žagrović. My comment: How could they not? Scientists map genes at work in human embryos’ earliest days Excerpt: … the act of creation that gives … Anti-entropic effects on the origin of life
See also: Ecological validity vs evolutionary theory Symbiosis becoming permanent: Survival of the luckiest Published in: Proceedings of the National Academy of Sciences (PNAS) f the United States of America Excerpt: …since the 1980s, the idea that the mitochondria and plastids (chloroplasts) of eukaryotic cells arose through endosymbiosis has been about as universally accepted as … RNA-mediated permanent symbioses
Beyond neo-Darwinism—an epigenetic approach to evolution Excerpt from 6/21/79 The evidence suggests… that a relative lack of natural selection may be the prerequisite for major evolutionary advance. Nutrient-dependent/pheromone-controlled adaptive evolution: a model. Excerpt from 6/14/13 (34 years later) …the epigenetic ‘tweaking’ of the immense gene networks that occurs via exposure to nutrient chemicals and pheromones … The stability of organized genomes
The American Society for Clinical Pathology (ASCP) is a professional association based in Chicago, Illinois encompassing 130,000 pathologists and laboratory professionals. (MLS is the acronym for Medical Laboratory Scientist) I received this notice today from the American Society for Clinical Pathology: Excerpt: Dear James V Kohl, MLS(ASCP)CM, Congratulations on successful completion of the ASCP Board … ASCP MLS certification
Evidence That the Origin of Naked Kernels During Maize Domestication Was Caused by a Single Amino Acid Substitution in tga1 Excerpt: “Our molecular and genetic analyses of tga1 show how a simple amino acid change can alter protein function and thereby drive the evolution of a new phenotypic state.” Reported as: Study shows how a … Domestication via a single amino acid substitution
The environmental influence on epigenetics Excerpt: Let the (informed) debate begin. My comment: Informed debate is not possible in the ScienceX venue. See for comparison: Riding the Evolution Paradigm Shift With Eugene Koonin Excerpt: “…the new understanding of evolution needs to integrate what we now know about viruses and virus-host interactions which, from my own … Koonin: viruses killed neo-Darwinism
Summary: Given what is currently known about RNA-mediated cell type differentiation in all genera, it may be impossible for theorists to link mutations to evolution via glycosylation. miRNA proxy approach reveals hidden functions of glycosylation Abstract excerpt: Glycosylation, the most abundant posttranslational modification, holds an unprecedented capacity for altering biological function. Journal article excerpt: …glycans … microRNAs, glycosylation, and genomes
Summary: The nutrient-dependent microRNA/messenger RNA balance links virus-induced entropic elasticity and the anti-entropic epigenetic effects of nutrient-dependent protein biosynthesis and degradation to everything that is currently known about RNA-directed DNA methylation and RNA-mediated amino acid substitutions. The substitutions differentiate the cell types of all genera. That fact is not being reported in most of the … Missing a fact: microRNAs are genomic biomarkers
