genotype

Quantum initiation of cold chemistry vs Hypeology (2)

See first: Quantum initiation of cold chemistry vs Hypeology (1) Genotype Genotype is a betting and manipulation game about cross-breeding pea plants, as in Gregor Mendel’s famous experiments. Players compete over three generations to predict the traits of new offspring, by controlling the parent plants’ genetic makeup (“genotype”). The offspring are determined by a die-roll at the end of each round and become the starting parents for the next generation. Changing the parent genotypes dramatically alters the likelihood of the…

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Energy-dependent purifying selection / autophagy (5)

See: Energy-dependent purifying selection / autophagy (4) See also: Team develops method to better identify genes involved in diseases If we can pinpoint the genetic mutations that cause a particular disease, we can associate those mutations with specific proteins, and then design drugs to block or activate those proteins. We can also measure the activity of proteins identified in this manner to diagnose diseases more accurately, which is a major goal of precision medicine. In: Histone Acetylome-wide Association Study of…

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We need pattern recognition, not a prologue

Prolegomenon “a preliminary discussion…; a prologue.” “… we need a mapping from genotype to phenotype, from phenotype to what is selected, and from what is selected to the new genotype (Lewontin, 1961). — cited in Prolegomenon to patterns in evolution Excerpt:  “…we cannot derive what selection, acting at the level of the whole organism in its world, will “select” among the possible but unprestatable…” My comment: Organisms naturally select the nutrients that enable thermodynamic cycles of protein biosynthesis and degradation,…

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Genotype, observed phenotype, and distinctly disordered behaviors

Schizophrenia not a single disease but multiple genetically distinct disorders September 15, 2014 By Jim Dryden News article excerpt: “Genes don’t operate by themselves,” said C. Robert Cloninger, MD, PhD, one of the study’s senior investigators. “They function in concert much like an orchestra, and to understand how they’re working, you have to know not just who the members of the orchestra are but how they interact.” My comment: Robert Cloninger and Jay R. Feierman were psychiatry post-doc residents at…

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Jay R. Feierman

In his posts that I have linked below, Jay R. Feierman takes us from random mutations on which natural selection acts to natural selection for phenotypes and changes in the brain that lead to increased reproductive success. According to him, the change in the brain can be called an adaptation. In my model, ecological variation and nutrient-dependent pheromone-controlled epigenetically-effected ecological, social, neurogenic, and socio-cognitive niche construction enable organismal complexity of the human brain. Ecological variation links the epigenetic landscape to…

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  • Randomness and Divine Providence
    A Q&A on randomness and God’s providence …the main goal is to really put together a collection of scholarly studies of these issues: physicists, biologists, […]
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