George M. Church

microRNA-mediated cures (7)

Pharmacogenomics: A road ahead for precision medicine in psychiatry 10/6/21 In this 2017 Precision Medicine Virtual Conference presentation, I linked the National Microbiome Initiative from microbial quorum sensing to the physiology of pheromone-regulated genetic processes of reproduction and endogenous RNA interference (#RNAi) via chromosomal rearrangements in flies from the works of Thomas Hunt Morgan (1910) to sympatric speciation across kingdoms. The chromosomal rearrangements link light-activated carbon fixation to the ATP-dependent creation of RNA and fixation of amino acid substitutions links…

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microRNA-mediated cures (6)

Aaron Siri tweeted this on 12/9/21 “Call to action for all MDs, DOs, and PhDs: If you want the FDA to release the documents submitted by Pfizer to license its Covid V as soon as possible, please join PHMPT right now at Public Health and Medical Professionals for Transparency” Four days after the Pfizer vaccine was approved for ages 16+, we submitted a Freedom of Information Act Request to the FDA for all of the data within Pfizer’s COVID-19 vaccine…

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Naturally attenuated viral endemicity (10)

See: Naturally attenuated viral endemicity (9) Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life” 4/25/20 links God’s Creation of energy-as-information from Peptide synthesis at the origin of life 11/13/20 to naturally attenuated viral endemicity across kingdoms via food energy-dependent pheromone-regulated genetic processes of reproduction. See for comparison: Kinematic self-replication in reconfigurable organisms This suggests other unique and useful phenotypes can be rapidly reached from wild-type organisms without selection or genetic engineering… Conclusion: Even if the behaviors…

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Naturally attenuated viral endemicity (3)

See first: Naturally attenuated viral endemicity (2) Conclusion: Energy-dependent changes in angstroms to ecosystems must be linked to the functional structure of supercoiled DNA via peptide synthesis at the origin  of life and single nucleotide polymorphisms (SNPs) in microRNAs. See also: Spatiotemporal regulation and roles of reproductive phasiRNAs in plants 11/11/21 …co-suppression was discovered as a pioneer silencing phenomenon of RNA interference (RNAi) in petunia in 1990… President Joe Biden’s scientific advisor, Eric Lander linked the facts about co-suppression and…

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Orchestrated death: Philip C. Ball

Topological phonon-polariton funneling in midinfrared metasurfaces 10/8/21 was reported as Researchers announce photon-phonon breakthrough Re: “…coupling of topological light and lattice vibrations to form chiral half-light half-vibration excitations…” Light-activated changes in the pH-dependent functional structure of vibrating supercoiled DNA links God’s Creation of sunlight and humidity to biophysical constraints on the chemistry of achiral glyine in position 6 in the gonadotropin hormone releasing hormone (GnRH) decapeptide (in all jawed vertebrates). See: Evolution of Constrained Gonadotropin-releasing Hormone Ligand Conformation and Receptor…

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God’s microRNA-mediated Creation of genotypes (8)

See first: God’s microRNA-mediated Creation of genotypes (7) The current issue of Science Magazine supports Trump’s claim via the claims in: Protein-coding repeat polymorphisms strongly shape diverse human phenotypes 9/23/21 The repeat polymorphisms vary with ethnicity, which explains the link from what different human populations eat to the pheromone-regulated genetic processes of reproduction across kingdoms from cyanobacteria to humans. See next: An integrated network analysis approach to identify potential key genes, transcription factors, and microRNAs regulating human hematopoietic stem cell…

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Natural selection for adaptation (7)

Microbial signatures in the lower airways of mechanically ventilated COVID-19 patients associated with poor clinical outcome 8/31/21 was reported as: High virus count in the lungs drives COVID-19 deaths 8/31/21 …the study revealed that those who died had on average 50 percent lower production of a type of immune chemical that targets the coronavirus compared with the COVID-19 patients who survived the illness. These customized proteins are part of the body’s adaptive immune system, a subset of cells and chemicals…

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MicroRNA-mediated population control (9)

See first: MicroRNA-mediated population control (8) 8/6/21 Light-activated microRNA biogenesis and peptide synthesis at the origin of life link biophysical constraints on the 2nd Law of thermodynamics  to microRNA-mediated biophysically constrained viral latency in all model organisms. Added support for the facts were published on 8/11/21. See: Decreased inhibition of exosomal miRNAs on SARS-CoV-2 replication underlies poor outcomes in elderly people and diabetic patients The facts were reported as: Study finds four circulating miRNAs which could effectively inhibit SARS-CoV-2 replication…

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MicroRNA-mediated population control (6)

7/29/21 I linked fixation of one amino acid substitution, EDAR V370A from the diet of human populations in East and central China to the New World during the past 5-10K years of ecological adaptations via https://nature.com/news/past-5-000-years-prolific-for-changes-to-human-genome-1.11912 WHO still hates me for doing that. How? “The findings confirm their earlier work suggesting that the majority of variants, including potentially harmful ones, were picked up during the past 5,000–10,000 years.” Clearly, there has never been support for stupid theories about the emergence…

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microRNA-mediated election cycles (4)

Computational designing of a peptide that potentially blocks the entry of SARS-CoV, SARS-CoV-2 and MERS-CoV and A paradigm shift in cell-free approach: the emerging role of MSCs-derived exosomes in regenerative medicine 7/12/21 support the same conclusion: God’s Creation of sunlight and humidity link Peptide synthesis at the origin of life 11/13/20 from biophysically constrained viral latency to healthy longevity across kingdoms via the physiology of reproduction and Biblical Genesis. See: microRNA-mediated election cycles (3) If you can’t link the works…

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