George M. Church

Natural selection for adaptation (7)

Microbial signatures in the lower airways of mechanically ventilated COVID-19 patients associated with poor clinical outcome 8/31/21 was reported as: High virus count in the lungs drives COVID-19 deaths 8/31/21 …the study revealed that those who died had on average 50 percent lower production of a type of immune chemical that targets the coronavirus compared with the COVID-19 patients who survived the illness. These customized proteins are part of the body’s adaptive immune system, a subset of cells and chemicals…

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MicroRNA-mediated population control (9)

See first: MicroRNA-mediated population control (8) 8/6/21 Light-activated microRNA biogenesis and peptide synthesis at the origin of life link biophysical constraints on the 2nd Law of thermodynamics  to microRNA-mediated biophysically constrained viral latency in all model organisms. Added support for the facts were published on 8/11/21. See: Decreased inhibition of exosomal miRNAs on SARS-CoV-2 replication underlies poor outcomes in elderly people and diabetic patients The facts were reported as: Study finds four circulating miRNAs which could effectively inhibit SARS-CoV-2 replication…

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MicroRNA-mediated population control (6)

7/29/21 I linked fixation of one amino acid substitution, EDAR V370A from the diet of human populations in East and central China to the New World during the past 5-10K years of ecological adaptations via https://nature.com/news/past-5-000-years-prolific-for-changes-to-human-genome-1.11912 WHO still hates me for doing that. How? “The findings confirm their earlier work suggesting that the majority of variants, including potentially harmful ones, were picked up during the past 5,000–10,000 years.” Clearly, there has never been support for stupid theories about the emergence…

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microRNA-mediated election cycles (4)

Computational designing of a peptide that potentially blocks the entry of SARS-CoV, SARS-CoV-2 and MERS-CoV and A paradigm shift in cell-free approach: the emerging role of MSCs-derived exosomes in regenerative medicine 7/12/21 support the same conclusion: God’s Creation of sunlight and humidity link Peptide synthesis at the origin of life 11/13/20 from biophysically constrained viral latency to healthy longevity across kingdoms via the physiology of reproduction and Biblical Genesis. See: microRNA-mediated election cycles (3) If you can’t link the works…

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microRNA-mediated replication timing (5)

Facts about energy-dependent microRNA-mediated biophysical constraints, which link protonated RNA interference (RNAi) to cell type differentiation across kingdoms via the physiology of reproduction and fixation of amino acid substitutions in organized genomes, are included in: pre-mRNA spatial distributions suggest that splicing can occur post-transcriptionally 6/29/21 Our results suggest a model in which transcription and splicing are largely independent, and the existence of a slow moving zone around the transcription site allows for the unification of co-transcriptional and post-transcriptional models of…

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microRNA-mediated replication timing (3)

miRNAs; a novel strategy for the treatment of COVID-19 6/28/21 Several previous studies have shown that host miRNAs play an anti-viral role and improve the treatment of patients with COVID-19. miRNAs by binding to the 3′-UTR or 5′-UTR of viral RNA play an important role in COVID-19-host interplay and viral replication. That fact makes it easier to convict Facebook of crimes against humanity because their censors prevent me from including links to autophagy.pro, and to microRNA.pro which expose the scientific…

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Light-activated carbon fixation did not evolve (5)

See first: The tipping point (revisited): 120K 5/12/21 Church Speaks: The cyanobacteria fix [carbon via] light…Under ideal circumstances, they can be maybe seven to ten times more productive per photon.” George M. Church et al patented this naturally occurring process. On 5/12/21, I was pleasantly surprised to see the facts represented in this trail-side placard at Canyonlands National Park. The facts make this patent worthless: RNA-Guided Human Genome Engineering See why: Light-activated binding together of sand and other soil particles…

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Quantum Darwinism (5)

See with my added emphasis: Parallel genetics of regulatory sequences using scalable genome editing in vivo 4/13/21 [Energy-dependent biophysically-constrained microRNA-mediated] Regulatory elements must ultimately be understood within their genomic environment and development- or tissue-specific contexts. Gene-centric theorists are too stupid to start with God’s Creation of energy, which must be linked from regulatory elements to regulation of the genomic environment before the effects of energy can be understood in any context whatsoever. See for context: Energy as information and constrained…

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Quantum Darwinism (4)

How metformin affects various malignancies by means of microRNAs: a brief review 4/13/21 Metformin adjusts cellular energy metabolism through…an important metabolic sensor that is activated under cellular stress conditions and limits energy consumption by affecting ATP production and consumption [1, 2]. The link from naturally occurring light-activated carbon fixation to God’s ATP-dependent Creation of RNA, protonated RNA interference, and biophysically constrained viral latency became clearer in 1964. Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism…

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Pheromones protect us from viruses (8)

See first: Pheromones protect us from viruses (7) Summary: When others link God’s Creation of anti-entropic virucidal light to pH-dependent biophysically constrained viral latency via His Creation of water, which is required for the creation of all oxygen-dependent life on Earth, we will see how God’s Creation of Genotypes in all species once protected them, and us, from the virus-driven degradation of messenger RNA. More than 118,000 indexed published articles mention ‘microRNA.’ It is long past time for theorists to…

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