glycine

Atomic theory vs facts about hydrogen-atom transfer

If, in some cataclysm, all scientific knowledge were to be destroyed, and only one sentence passed on to the next generation of creatures, what statement would contain the most information in the fewest words? I believe it is the atomic hypothesis, or the atomic fact, or whatever you wish to call it, that all things are made of atoms – little particles that move around in perpetual motion, attracting each other when they are a little distance apart, but repelling…

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Energy-dependent hydrogen bonds in supercoiled DNA

Chirality Check Most biological macromolecules are homochiral, and enzymes help to maintain this state of affairs; for example, checkpoints ensure that only l-amino acids are incorporated into proteins during translation. The fixation of the only achiral amino acid, glycine in position 6 of the gonadotropin releasing hormone decapeptide protein links the nutrient energy-dependent pheromone-controlled physiology of reproduction from yeasts to humans. That fact about RNA-mediated protein folding chemistry is missing from the chirality check, It also is missing from representations…

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Amino acid-dependent cell type differentiation

mTORC1 is a protein complex that functions as a nutrient/energy/redox sensor and controls protein synthesis. “MCRS1 Binds and Couples Rheb to Amino Acid-Dependent mTORC1 Activation” reported as: Oncogene regulated by nutrients identified A protein that is a molecular link connects Rheb-GTP to mTORC1 activation, lysosomes, and amino acid responses. Depletion of the protein links a chain of interactions to mTORC1 inactivation. The authors address the complexity of the biophysically constrained chemistry of RNA-directed DNA methylation and RNA-mediated protein folding, which…

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Mutisensory integration: watching the paradigm shift

Multisensory integration and causal inference in the brain Excerpt (with my emphasis):  It is largely unknown how the brain implements prior knowledge and expectations. Various mechanisms have been proposed such as spontaneous activity (Berkes et al., 2011), the fraction of neurons encoding a particular feature (Girshick et al., 2011), their response gain and tuning curves or connectivity and top-down projections from higher order areas (Rao and Ballard, 1999).” My comment: The brain implements prior knowledge and expectations through nutrient-dependent pheromone-controlled…

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Origin of life and cancer (1,2,3)

1) On the Origins of Life The physics of the light-induced de novo creation of the amino acids was placed into the context of  ‘cyanosulfidic’ protometabolic systems chemistry. The systems chemistry links substitution of achiral glycine in the gonadotropin releasing hormone (GnRH) decapeptide to the biophysically constrained nutrient dependent RNA-mediated chemistry of protein folding in all vertebrates. The role of food odors and hormone-controlled cell type differentiation in all vertebrates also links changes in the balance of viral microRNAs and…

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Assembling yourself: Molecular self / other recognition

Chiral recognition and selection during the self-assembly process of protein-mimic macroanions Abstract excerpt: “We believe that delicate long-range electrostatic interactions could be responsible for such high-level chiral recognition and selection.” Article excerpt: “This self-assembly allows relatively simple building blocks to organize themselves into larger supramolecular structures, a phenomenon that has parallels with the formation of viral capsids (both in morphology and kinetics)37.” Reported as: Discovery demystifies origin of life chirality phenomenon Excerpt: “The origin of life is still a mystery…

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Quantum Superpositions: let there be light

Ideal Negative Measurements in Quantum Walks Disprove Theories Based on Classical Trajectories Reported as: Atoms can be in two places at the same time Excerpt: “This is not yet a proof that quantum mechanics hold for large objects,” cautions Alberti. My comment: I framed my comments and a question in the context of this article on physics. Their claim of a possible size limit on quantum superpositions seemed to divorce top-down causation from cell–cell communication in mammals. That suggested there…

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Quantum entanglement, mass, and biomass

Joseph Kover seems closer than most other physicists to linking light-induced amino acid substitutions to cell type differentiation and biomass via the biophysically constrained chemistry of protein folding.  Today he posted notice of the following publication with the comment: “… just what I was waiting for…” Entanglement Makes Quantum Particles Measurably Heavier, Says Quantum Theorist Excerpt: The discovery is a long sought-after link between the theories of quantum mechanics and general relativity See also this model by Joseph Kover: I’m…

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Glycine and GnRH: Am I being pedantic?

Posted to the FB page on 12/3/14 at Skeptics; Atheists; Realists; Agnostics; Humanists Stephen Hawking and Brian Cox take part in Monty Python sketch – video Excerpt: “I think you are being pedantic.” My comment: Some people may think I am being pedantic. My focus is not on physics; it is on the role of GnRH in cell type differentiation. My focus now extends from what is known about quantum physics, quantum smell, chirality, quantum biology, and quantum consciousness. What is known about chirality…

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Achiral GnRH: no prophesy, just prediction

Predictions build on facts, mysterious “tongues” do not. (1 Corinthians 14:2-4) Effective communication demands that audiences understand what serious scientists and theologians can or cannot predict. Predicting the end of evolutionary theory or the end of the world by focusing on a model of biological facts may be an important aspect of effective communication. A problem may be the words and phrases that pseudoscientists and serious scientists use. Some make biological facts seem like mysteries until the facts are effectively…

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