GnRH

Biologically uninformed science idiot: Self-defense (2)

Summary: “Construction of automata” is the operative phrase. But you must be willing to believe that the automata create themselves outside the context of the creation of sunlight and light-activated endogenous substrates in all cell types of all living genera. Causation, constructors and codes A formal definition of codes in general, and organic codes in particular, allows the relational diagram to be extended so as to capture this translation of formal cause into process. The extended relational diagram is used…

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Ecological adaptation: a new definition of heredity (4)

Experimentally Induced Metamorphosis in Axolotl (Ambystoma mexicanum) Under Constant Diet Restructures Microbiota Accompanied by Reduced Limb Regenerative Capacity (2018) Our results show that distinct bacterial communities inhabit individual organs of Axolotl and undergo substantial restructuring through metamorphosis. The restructuring during metamorphosis is biophysically constrained by feedback loops that link olfaction from food odors and pheromones to the creation of enzymes in bacteria and the secretion of the vertebrate decapeptide hormone GnRH (gonadotropin releasing hormone). See: Gonadotropin-releasing hormone agonist binding in…

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For God and Country

Energy-dependent structure and function: Until death (3)

Energy-dependent structure and function: Until death (2) The COMT Val158Met polymorphism supposedly is not found in species other than humans See: Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles This is also the first study establishing the COMT*L allele as the derived allele unique to humans. Other organisms do not commit suicide. That suggests the human specific COMT Val158Met substitution may be important to those who know very little about suicide prevention. For instance, see: The catechol-o-methyltransferase Val158Met polymorphism…

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For God and Country

Energy-dependent structure and function: Until death (2)

Energy-dependent structure and function: Until death (1) Terry Crews details alleged sexual assault by ‘high level’ Hollywood exec “This whole thing with Harvey Weinstein is giving me PTSD. Why? Because this kind of thing happened to ME…” Crews tweeted Tuesday. This claim helps to link the celebrity status of Hollywood victims like Robin Williams to the suicide rate in veterans who have returned from military service overseas with viruses. The viruses clearly link energy-dependent changes in the microRNA/messenger RNA balance…

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For God and Country

Energy-dependent structure and function: Until death (1)

The structure-energy landscape of NMDA receptor gating …using single-molecule Forster resonance energy transfer (smFRET), we map the energy landscape of the first transmembrane segment of the Rattus norvegicus NMDA receptor under resting and various liganded conditions. These results show kinetically and structurally distinct changes associated with apo, agonist-bound, and inhibited receptors linked by a linear mechanism of gating at this site. Furthermore, the smFRET data suggest that allosteric inhibition by zinc occurs by an uncoupling of the agonist-induced changes at…

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MicroRNAs: Nature’s secret ingredient

The Secret Ingredient That Stops Honeybees From Becoming Queens Learning more about how these molecules can affect species in different kingdoms — like plants and insects or plants and humans — could help identify therapeutic applications for cancer treatments or to suppress allergic reactions, Dr. Askenase said. “Some important biological problems could now be addressed with this new knowledge of how nature works,” he said. Plant microRNAs in larval food regulate honeybee caste development Overall, our study uncovered a new…

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Your indifference is killing you and others

Summary: Coherence-inducing mechanisms is double-speak for mechanisms that are nutrient-dependent and pheromone-controlled. Feedback loops link odor and pheromone signaling with reproduction has been presented in double-speak as Looplessness in networks is linked to trophic coherence We are currently studying the entropy of the coherence ensemble we defined for this work. “In general, higher trophic coherence would be associated with lower entropy states, which means that if networks are more coherent than the random expectation there must indeed be some kind…

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Can protein folding chemistry be understood by theorists?

Excerpt: The researchers believe their discovery dovetails with their research on how tumor viruses and cancer mutations change a cell’s DNA structure and organization to cause uncontrolled cell growth. Aye group discovers avenue for precision cancer treatment One challenge is that multiple variations, or isoforms, of the same protein can all catalyze the same cellular function, “but the nuances of biology rest in how individual isoforms are regulated,” Aye said. Natural selection for energy-dependent codon optimality regulates the creation of…

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Energy-dependent physical and biophysical constraints (9)

Summary: Energy determines genome compaction because activity in the nucleus is energy-dependent. Chromatin chains link energy-dependent changes in base pairs from single nucleotide polymorphisms to fixation of RNA-mediated amino acid substitutions in organized genomes via the physiology of pheromone-controlled reproduction. It’s all about the base. Energy-dependent physical and biophysical constraints (8) ChromEMT: Visualizing 3D chromatin structure and compaction in interphase and mitotic cells Excerpt 1) The chromatin structure of DNA determines genome compaction and activity in the nucleus. My comment:…

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Energy-dependent physical and biophysical constraints (8)

Summary: The role of vitamin C in the treatment of pain: new insights links what is known about the “superfood” Spirulina (blue-green algae), which is grown in marine and freshwater environments, to the stability of all organized genomes via its biological activities, such as antioxidant, anti-diabetic, cholesterol-controlling and insulin resistance effects. The biological activities are energy-dependent and they link the anti-entropic virucidal energy of sunlight to all biodiversity via the pheromone-controlled physiology of reproduction and microRNAs in plants and animals.…

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