GnRH

Can protein folding chemistry be understood by theorists?

August 3, 2017
James Kohl
Adaptations, Alternative Splicings, Autophagy, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA interference, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
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Excerpt: The researchers believe their discovery dovetails with their research on how tumor viruses and cancer mutations change a cell’s DNA structure and organization to cause uncontrolled cell growth. Aye group discovers avenue for precision cancer treatment One challenge is that multiple variations, or isoforms, of the same protein can all catalyze the same cellular function, “but the nuances of biology rest in how individual isoforms are regulated,” Aye said. Natural selection for energy-dependent codon optimality regulates the creation of…

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Energy-dependent physical and biophysical constraints (9)

July 28, 2017
James Kohl
Adaptations, Autophagy, Cytosis, Diseases & Disorders, Ecology, Human Pheromones, Light Energy, Model Organisms, Nutrigenomics, RNA Directed, RNA-directed DNA methylation, RNA-mediated gene silencing, Variations, What's in the News
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Summary: Energy determines genome compaction because activity in the nucleus is energy-dependent. Chromatin chains link energy-dependent changes in base pairs from single nucleotide polymorphisms to fixation of RNA-mediated amino acid substitutions in organized genomes via the physiology of pheromone-controlled reproduction. It’s all about the base. Energy-dependent physical and biophysical constraints (8) ChromEMT: Visualizing 3D chromatin structure and compaction in interphase and mitotic cells Excerpt 1) The chromatin structure of DNA determines genome compaction and activity in the nucleus. My comment:…

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Energy-dependent physical and biophysical constraints (8)

July 27, 2017
James Kohl
Adaptations, Alternative Splicings, biophotonics, Cytosis, Diseases & Disorders, Ecology, Human Brain, Human Pheromones, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity, Variations
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Summary: The role of vitamin C in the treatment of pain: new insights links what is known about the “superfood” Spirulina (blue-green algae), which is grown in marine and freshwater environments, to the stability of all organized genomes via its biological activities, such as antioxidant, anti-diabetic, cholesterol-controlling and insulin resistance effects. The biological activities are energy-dependent and they link the anti-entropic virucidal energy of sunlight to all biodiversity via the pheromone-controlled physiology of reproduction and microRNAs in plants and animals.…

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Dispensing with all pseudoscientific nonsense about evolution (2)

April 25, 2017
James Kohl
Adaptations, Diseases & Disorders, Ecology, RNA Directed
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Dispensing with all pseudoscientific nonsense about evolution (1) See also: Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk Reported as: Hundreds of Genomic Regions Linked to Age at Menarche Age at onset of puberty is affected by a combination of genetic, nutritional, and other environmental factors and that timing, in turn, is associated with risk of cancer later in life. Who will be next to link energy-dependent…

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Energy-dependent hydrogen bonds in supercoiled DNA

January 2, 2017
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Model Organisms, Nutrigenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA–Mediated Epigenetic Heredity, Variations
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Chirality Check Most biological macromolecules are homochiral, and enzymes help to maintain this state of affairs; for example, checkpoints ensure that only l-amino acids are incorporated into proteins during translation. The fixation of the only achiral amino acid, glycine in position 6 of the gonadotropin releasing hormone decapeptide protein links the nutrient energy-dependent pheromone-controlled physiology of reproduction from yeasts to humans. That fact about RNA-mediated protein folding chemistry is missing from the chirality check, It also is missing from representations…

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Energy-dependent chirality

January 1, 2017
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity, Variations
One Comment

See also: Achiral glycine Summary: Virus-driven energy theft alters the interactions between physics and chemistry that maintain biophysically constrained biodiversity. That’s how viruses are linked from mutations to all pathology. Nutrient energy-dependent changes in the context of the pheromone-controlled physiology of reproduction biophysically constrain biodiversity via the fixation of amino acid substitutions in supercoiled DNA, which protects organized genomes from virus-driven pathology. Chirality (chemistry) Two enantiomers of a generic amino acid that is chiral The chirality of amino acids is energy-dependent…

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Virus-driven mutation or amino acid substitution

November 13, 2016
James Kohl
Adaptations, Alternative Splicings, Diseases & Disorders, Ecology, Model Organisms, RNA Directed, RNA methylation, RNA-directed DNA methylation
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A computer program just ranked the most influential brain scientists of the modern era Excerpt: “My first thought was, ‘Who could I tell without appearing immodest?’” he said. “I then realized the only people who would want to hear about this are my children!” My comment: Oxytocin-related peptides are 9-13 amino acids long, but they can be recognized in genomic sequences. That allows them to be placed into the context of claims that link the nutrient energy-dependent de novo creation…

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Conserved biophotonic emissions

August 22, 2016
James Kohl
RNA Directed
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Human high intelligence is involved in spectral redshift of biophotonic activities in the brain The tendency of the spectral redshift of glutamate-induced biophotonic emissions in this study is in the order of frog, mouse, chicken, pig, monkey, and human, which is almost consistent with the phylogenetic tree. Although the present imaging technique could not distinguish and determine what types of neurons emit what types of spectral biophotons or whether a neuron or type of neurons emit different spectral biophotons, we…

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Biophysically constrained cell type differentiation

August 13, 2016
James Kohl
RNA Directed
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Intrinsic limits to gene regulation by global crosstalk Excerpt: A paradigmatic example is that of the aminoacyl transfer RNA synthetase1, which uses kinetic proofreading2 to load appropriate amino acids onto matching tRNAs. This and other examples—including DNA replication, ligand sensing3, protein–protein interactions4,5,6,7,8,9, recognition events in the immune system10,11 and molecular self-assembly12—indicate that biology places a large premium on the reduction of unintended ‘crosstalk’, a generic term that encompasses all potentially disruptive processes due to reactions between non-cognate substrates. Reported as:…

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The Origin of Information (2)

July 28, 2016
James Kohl
Adaptations, Alternative Splicings, biophotonics, Diseases & Disorders, Ecology, Human Brain, Light Energy, Model Organisms, Neuronal Plasticity, Nutrigenomics, Pharmacogenomics, Physics, RNA Directed, RNA methylation, RNA-directed DNA methylation, RNA-mediated epigenetic regulation of gene expression, RNA-mediated gene silencing, RNA-mediated toxicity, RNA–Mediated Epigenetic Heredity
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See also: The Origin of Information (1) Labroots Neuroscience virtual event: RNA mediated molecular epigenetics and virus driven entropy (working title: The Origin of Information) Published to Youtube March 2, 2016 RNA mediated molecular epigenetics and virus driven entropy Presented March 16 and 17, 2016  Login for free and go to the Poster Hall section on Neuron Biology for a full screen display of the poster or view the poster on Figshare Abstract: Energy-dependent molecular epigenetics support Einstein’s complete molecular…

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