GnRH

Biophysically constrained cell type differentiation

Intrinsic limits to gene regulation by global crosstalk Excerpt: A paradigmatic example is that of the aminoacyl transfer RNA synthetase1, which uses kinetic proofreading2 to load appropriate amino acids onto matching tRNAs. This and other examples—including DNA replication, ligand sensing3, protein–protein interactions4,5,6,7,8,9, recognition events in the immune system10,11 and molecular self-assembly12—indicate that biology places a large premium on the reduction of unintended ‘crosstalk’, a generic term that encompasses all potentially disruptive processes due to reactions between non-cognate substrates. Reported as:…

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The Origin of Information (2)

See also: The Origin of Information (1) Labroots Neuroscience virtual event: RNA mediated molecular epigenetics and virus driven entropy (working title: The Origin of Information) Published to Youtube March 2, 2016 RNA mediated molecular epigenetics and virus driven entropy Presented March 16 and 17, 2016  Login for free and go to the Poster Hall section on Neuron Biology for a full screen display of the poster or view the poster on Figshare Abstract: Energy-dependent molecular epigenetics support Einstein’s complete molecular…

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War Games: False Flag Terrorism

Sirius Cyantis (aka Sean Ovis) takes my claims about virus-driven energy theft and pathology outside the context of creationism.  Using his assumed name, he places them into the context of support for evolution. That’s an example of what happens on the “False Flag” Creationism FB group. In the context of combating evolution to fight disease, the war games become more interesting. Most people in False Flag groups do not know who they are fighting against. In the end it won’t…

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RNA-mediated physics, chemistry, and molecular epigenetics (3)

Microtargeting cancer metabolism: opening new therapeutic windows based on lipid metabolism reported as: Using microRNAs to target cancer cells By Dawn Hayward Conclusion:  MicroRNAs stand out from conventional gene-therapy-based approaches and have a niche in lipid metabolism. They can be designed specifically to target a gene and serve as modulators rather than on/off switches. Increased lipid formation and breakdown in cancer cells creates vulnerability that might be taken advantage of by microRNAs. In addition, cancer as a whole involves a…

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RNA-mediated physics, chemistry, and molecular epigenetics (2)

9/16/15 This is an excellent introduction to speculation about how quantum mechanics might be linked from physics and chemistry to the conserved molecular mechanisms of epigenetically-effected biologically-based RNA-mediated cause and effect, which all serious scientists already know must link angstroms to ecosystems via the innate immune system, the physiology of reproduction, and supercoiled DNA. The introduction to speculation may help you to explain why more scientific progress has not been made since 1944, when Schrodinger claimed: Indeed, in the case…

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Ignore the evidence: Rachel Feltman

“There is incontrovertible evidence that Alzheimer’s Disease has a dormant microbial component. We can’t keep ignoring all of the evidence” –Professor Douglas Kell, Manchester University Experts Say There’s a Herpes-Alzheimer’s Link Excerpt: …herpes has been linked to damage in the central nervous system and the limbic system, which is associated with mental decline and personality changes, the Telegraph reported. The experts called for a deeper investigation into the connection. Calm down: Herpes probably isn’t going to give you Alzheimer’s Excerpt:…

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RNA-mediated DNA modifications

A new way to discover DNA modifications Excerpt: Using their approach, which combines bioanalytical chemistry, comparative genomics, and a special type of DNA sequencing, the team has discovered a DNA modification that helps bacteria to protect their genomes from viral infection. My comment: There is one way to link nutrient-dependent microRNA flanking sequences from adhesion proteins to supercoiled DNA, which protects the organized genomes of all living genera from virus-driven entropy. It starts with energy-dependent changes in hydrogen-atom transfer in…

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The toxic river of neo-Darwinian pseudoscience

Mechanistic Basis of Resistance to PCBs in Atlantic Tomcod from the Hudson River Excerpt: Our results indicate that resistance can be due to one structural change in the coding region of a single gene and that evolutionary change in anthropogenically challenged natural populations can be rapid. My comment: Structural changes to the coding region of all genes are nutrient-dependent. This article was published in 2011 and it ignored everything known to serious scientists about the obvious links from non-coding RNAs…

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Effects on invertebrate GnRH and affects on primate behavior

Introduction: Energy-dependent changes in hydrogen-atom transfer in DNA base pairs in solution have again been linked to hormone-organized and hormone-activated behaviors by the conserved molecular mechanisms we detailed in the molecular epigenetics section of our 1996 Hormones and Behavior review. The practical application of those details has been reported in the context of this article, published in the New England Journal of Medicine. Effects of Testosterone Treatment in Older Men Daily Diagnosis is emailed each weekday to members of the…

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Assumptions prove ignorance

Testing Einstein’s Equivalence Principle With Fast Radio Bursts Excerpt: Assuming as a lower limit that the time delays are caused mainly by the gravitational potential of the Milky Way, we prove that fast radio bursts (FRBs) of cosmological origin can be used to constrain the EEP with high accuracy. My comment: Theoretical physicists are allowed to start with assumptions and link them to theories via what they consider to be proof of their assumptions. Unfortunately, the proof of their assumptions…

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