GnRH

Ignore the evidence: Rachel Feltman

“There is incontrovertible evidence that Alzheimer’s Disease has a dormant microbial component. We can’t keep ignoring all of the evidence” –Professor Douglas Kell, Manchester University Experts Say There’s a Herpes-Alzheimer’s Link Excerpt: …herpes has been linked to damage in the central nervous system and the limbic system, which is associated with mental decline and personality changes, the Telegraph reported. The experts called for a deeper investigation into the connection. Calm down: Herpes probably isn’t going to give you Alzheimer’s Excerpt:…

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RNA-mediated DNA modifications

A new way to discover DNA modifications Excerpt: Using their approach, which combines bioanalytical chemistry, comparative genomics, and a special type of DNA sequencing, the team has discovered a DNA modification that helps bacteria to protect their genomes from viral infection. My comment: There is one way to link nutrient-dependent microRNA flanking sequences from adhesion proteins to supercoiled DNA, which protects the organized genomes of all living genera from virus-driven entropy. It starts with energy-dependent changes in hydrogen-atom transfer in…

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The toxic river of neo-Darwinian pseudoscience

Mechanistic Basis of Resistance to PCBs in Atlantic Tomcod from the Hudson River Excerpt: Our results indicate that resistance can be due to one structural change in the coding region of a single gene and that evolutionary change in anthropogenically challenged natural populations can be rapid. My comment: Structural changes to the coding region of all genes are nutrient-dependent. This article was published in 2011 and it ignored everything known to serious scientists about the obvious links from non-coding RNAs…

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Effects on invertebrate GnRH and affects on primate behavior

Introduction: Energy-dependent changes in hydrogen-atom transfer in DNA base pairs in solution have again been linked to hormone-organized and hormone-activated behaviors by the conserved molecular mechanisms we detailed in the molecular epigenetics section of our 1996 Hormones and Behavior review. The practical application of those details has been reported in the context of this article, published in the New England Journal of Medicine. Effects of Testosterone Treatment in Older Men Daily Diagnosis is emailed each weekday to members of the…

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Assumptions prove ignorance

Testing Einstein’s Equivalence Principle With Fast Radio Bursts Excerpt: Assuming as a lower limit that the time delays are caused mainly by the gravitational potential of the Milky Way, we prove that fast radio bursts (FRBs) of cosmological origin can be used to constrain the EEP with high accuracy. My comment: Theoretical physicists are allowed to start with assumptions and link them to theories via what they consider to be proof of their assumptions. Unfortunately, the proof of their assumptions…

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Theorists can’t understand biology

See also: Neuroplasticity Thanks to Teresa Binstock for calling my attention to this:   Thanks to Anna Di Cosmo for calling the attention of others to this: My comment: Attempts to explain the “binding problem” of integration in the context of ecoimmunology and disease ecology compared to emergence and evolution are examples of how much pseudoscientific nonsense has been accepted and touted in the context of the neo-Darwinian “Modern Synthesis.” For comparison, serious scientists have detailed a model of top-down…

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Receptor methylation controls behavior

The protein arginine methyltransferase PRMT5 promotes D2-like dopamine receptor signaling Excerpt 1) The addition of a methyl group to an arginine residue can remove a hydrogen bond donor and decrease the electrostatic surface potential at the residue, resulting in a change in size and hydrophobicity that can affect its interaction with binding partners (21). Excerpt 2) Together, these results led us to propose that arginine methylation promotes D2-like dopamine receptor signaling and that this mechanism of receptor regulation is conserved…

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Controled Stem Cell Expansion

Serine … is one of the proteinogenic amino acids. [It]… is classified as a polar amino acid. My comment: Serine synthesis in the body is linked to glycine, which also may be naturally produced when UV light illuminates simple ices (e.g., combinations of water, methanol, hydrogen cyanide, and ammonia). That suggested to some people that glycine and other amino acids may be easily produced in cold regions of space, and the suggestion, like virtually all suggestions, seems to be believable…

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Olfaction & the octopus and human genomes

Secrets of the Deep: Scientists Sequence Genome of Octopus for First Time Excerpt: The genome was arranged differently than in other invertebrates and featured an expansion in a family of genes regulating nerve cell development that previously was thought to be enlarged only in vertebrates. My comment: RNA-mediated gene duplication and RNA-mediated amino acid substitutions link nutrient-dependent thermodynamic cycles of protein biosynthesis and degradation to RNA-mediated  organism level thermoregulation in bacteria, yeasts, insects, marine invertebrates such as octopuses,  mammals, humans…

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Epigenetic regulation of aging by glycine and GnRH

Summary:  “…the regulation of two genes involved with the production of glycine, the smallest and simplest amino acid, is partly responsible for some of the characteristics of aging. This indicates that the aging process in the mitochondrion is controlled by epigenetic regulation, not by mutations.” My comment: The broad-based extension of the fact that aging is epigenetically controlled, extends everything known about RNA-mediated cell type differentiation across the life history transitions of all genera. The focus here is on vertebrates,…

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