GnRH

Sackler Colloquium: Effects or AFFECTS on Behavior

Arthur M. Sackler Colloquium of the National Academy of Sciences, “Epigenetic Changes in the Developing Brain: Effects on Behavior,” held March 28–29, 2014, at the National Academy of Sciences in Washington, DC. The complete program and video recordings of most presentations are available on the NAS website. I reiterate: the title is: Epigenetic changes in the developing brain: Effects on behavior I was taught that the epigenetic landscape must be linked to physical landscape of DNA in organized genomes of…

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There’s a model for that!

Neuroscientists reveal mechanism crucial to molding male brains Excerpt 1) “…sex differences in brain function are established during the later stages of foetal development and around birth, but the actual cellular mechanisms underlying these important actions remained unknown.” My comment: In our 1996 Hormones and Behavior review we provided details about how these cellular mechanisms link sex differences in brain function, which are established during the later stages of fetal development, to the sex differences that are established perinatally. We…

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Biologists puzzled by evolved RNAs and decaying DNA

Horizontal Transfer of Entire Genomes via Mitochondrial Fusion in the Angiosperm Amborella (December, 2013) Excerpt) “The ancestral angiosperm-wide genome duplication apparent in the Amborella genome not only serves as a genetic marker for the origin of extant angiosperms, but it may also have set in motion a series of events as numerous genes evolved novel functions, eventually leading to modern flowering plants.” See also: The Amborella Genome and the Evolution of Flowering Plants Excerpt) “Evolution of Small RNAs More than…

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SNPs and millions of small variations in the human genome

Thousands of never-before-seen human genome variations uncovered Excerpt: “This approach has successfully pinpointed millions of small variations in the human genome. These variations arise from substitution of a single nucleotide base, called a single-nucleotide polymorphisms or SNP.” My comment: In the mouse-to-human model of nutrient-dependent RNA-mediated amino acid substitutions and cell type differentiation, one SNP is linked to one amino acid substitution and many different cell types in different tissues of different organs in different organ systems in mice and…

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Nothing new under the sun, except pseudoscientific nonsense

On the Importance of Being a Methodological Naturalist Posted on November 5, 2014 by David Sloan Wilson Excerpt: “…consider the flying spaghetti monster, a deity invented to poke fun at religion. It is ridiculous, but is there any way to prove that it doesn’t exist?” Conclusion: “If religious believers abandon methodological naturalism, then they are forced to deny not only the laws of physics and the facts biological evolution, but the histories of their own religions.” My comments: DS Wilson is…

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Pharmacogenomics

“The gene, cell, tissue, organ, organ-system pathway is a neuroscientifically established link between sensory input and behavior. Marts and Resnick (2007) stress the importance of this pathway in the context of a systems biology approach to pharmacogenomics.” (Kohl, 2012) “Naftolin (1981) stressed its importance to the understanding of sex differences. This pathway is sensitive to conditioning. Sensory input from an organism’s environment activates and reactivates the pathway and causes changes in hormone secretion that condition hormone-driven behavior.” (Kohl, 2012) See…

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2014 and 2004 Nobel Prize in Medicine

2014 Nobel Prize in Medicine is Awarded for Discovery of Brain’s ‘Inner GPS’ Excerpt: “… gray lines show the path followed by a rat as it moves around a box looking for pieces of food.” 2014 Nobel prize in physiology or medicine for finding brain’s ‘you are here’ cells Excerpt: John Stein, professor of physiology at Oxford University, said: “This is great news and well deserved. I remember how great was the scoffing in the early 1970s when John first…

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Unassailable evidence vs assumptions

Putting the theory before the data: Is “massive modularity” a necessary foundation of evolutionary psychology? Excerpt 1) “Anyone who attends HBES, EHBEA, ISHE or any of the other conferences dedicated to the approach will discover that new fields of study are constantly being approached through the lens of evolutionary theory.” Excerpt 2) “There is little to be gained by prematurely formalising the foundations of the field – putting the theory before the data – particularly if those foundations later turn…

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Forces of "Nature" limit dissemination of information

Force of nature gave life its asymmetry Excerpt: “In 2011, Meierhenrich and colleages showed4 that such light could transfer its handedness to amino acids. But even demonstrating how a common physical phenomenon would have favoured left-handed amino acids over right-handed ones would not tell us that this was how life evolved, adds Laurence Barron, a chemist at the University of Glasgow, UK. “There are no clinchers. We may never know.” My comment:I think the clincher is the creation of the…

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Systems biology and memory disorders

Reversal of cognitive decline: A novel therapeutic program Reported as: Memory loss associated with Alzheimer’s reversed: Small trial succeeds using systems approach to memory disorders News Article Excerpt: (1) eliminating all simple carbohydrates, leading to a weight loss of 20 pounds; (2) eliminating gluten and processed food from her diet, with increased vegetables, fruits, and non-farmed fish; (3) to reduce stress, she began yoga; (4) as a second measure to reduce the stress of her job, she began to meditate…

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